The study further shows that:
• ARVCF is a component of endothelial adherens junctions
• ARVCF stabilizes endothelial cell-cell junctions
• ARVCF binds to a separate pool of VE-cadherin that is unbound from p120-catenin
www.sciencedirect.com/science/arti...
For those interested in endothelial junctions: our latest paper is out in iScience, and it includes a mass spectrometry based VE-cadherin interactome!
Turns out that there are many more molecular intractions going on than just with the catenins…
See: www.sciencedirect.com/science/arti...
Last day to register for the EMBO Workshop "Building networks: Engineering in vascular biology" in #Barcelona, #Spain, 13–15 May 2026.
www.embl.org/about/info/course-and-co...
#EMBOBuildNetworks #EMBOevents 🧪
You’re too kind!
That is a pity! Until next time then, thanks for the shout out
We are excited to welcome Stephan Huveneers (University of Amsterdam) to our @sfb1348.bsky.social seminar @uni-muenster.de. He will speak about "Force-dependent regulation of endothelial adhesion in vascular development and disease”. Everyone is welcome! More: www.uni-muenster.de/SFB1348/en/i...
📩 Late with your abstract for 'Building networks: engineering in vascular biology'? You now have an extra week to send it over!
🔬 Join us at EMBL Barcelona this May to meet researchers working at the intersection of engineering and vascular biology. #EMBOBuildNetworks
s.embl.org/evb26-01-bl
With Tong Xu, @verajanssen.bsky.social and Nathalie Reinhard as shared first authors, we would like to thank everyone who contributed!
#Angiogenesis #VascularBiology #Endothelial #PortWineStains #SturgeWeberSyndrome #AmsterdamUMC
The article also includes a full phosphoproteomic dataset, provided as open-source data, mapping downstream signaling of the GNAQ p.R183Q mutation in endothelial cells. www.ebi.ac.uk/pride/archiv...
The study shows:
• How the Gαq-R183Q mutation in endothelial cells disrupts normal signaling, impairing cell migration and angiogenic sprouting
• That DSCR1.4 is a key mediator of these effects
• That inhibition of Calcineurin with Tacrolimus or depletion of DSCR1.4 can restore endothelial function
Very pleased with our newest publication! In this study, we identify the Calcineurin-NFAT-DSCR1.4 signaling pathway as a druggable driver of capillary malformations caused by the GNAQ p.R183Q mutation, which is associated with port-wine stains and Sturge-Weber syndrome.
🔗 article: rdcu.be/e2gRC
Flyer with announcement of the FEBS advanced course in Amsterdam
Join us in Amsterdam for a FEBS advanced course on "Functional Imaging of cellular dynamics" from 31st of May - 6th of June 2026
Info: microscopy2026.febsevents.org
🔬 Join us in Barcelona to meet researchers working at the intersection of engineering and vascular biology and discover cutting-edge techniques in spatial omics, advanced imaging, and the use of AI in vascular research. #EMBOBuildNetworks
13 – 15 May 2026
Register by 4 Feb: s.embl.org/evb26-01-bl
🔬 Join us in Barcelona to meet researchers working at the intersection of engineering and vascular biology and discover cutting-edge techniques in spatial omics, advanced imaging, and AI. #EMBOBuildNetworks @events.embl.org
13 – 15 May 2026. Register by 4 Feb: s.embl.org/evb26-01-bl
Save the date for the EMBO Workshop: Building networks: engineering in vascular biology EMBO Workshop www.embl.org/about/info/c...
May 13-15 2026, Barcelona.
Abstract deadline, Feb 4th!
Big news, EVBO community!
Our BLACK FRIDAY membership deal is live until 31 Dec 2025:
🔹 3-year full membership: €120
🔹 PhD/postdoc: €75
Join now ➜ evbo.org/index.php/me...
Plus, members get access to 3 exclusive vascular biology workshops in 2026. Don’t miss out!
🎓 Dr. Hooglugt!
On October 23rd, Aukie successfully defended his PhD thesis, “Balancing forces: endothelial mechanobiology in vascular dynamics and disease.
A huge congratulations from a proud team of supervisors @reinierboon.bsky.social, @huveneerslab.bsky.social & Dr. van der Stoel.
Goodmorning all! The EVBO board is back online! Please see our amazing speaker list and reserve the following dates for the upcoming EVBO autumn seminars. You can registration for the Zoom through the link in the email from our EVBO secretary.
The integrin odyssey – a journey full of fundamental discoveries url: journals.biologists.com/jcs/article/...
Great to start the day while reading this #integrin odyssey.
New vascular seminars coming up @evborg.bsky.social
Our new series of online EVBO seminars is kicking off! Bimonthly Vascular Biology on Tuesday afternoons. Want to join: go through the EVBO website for registration, evbo.org/index.php/ev...
Excited about this cutting-edge, cross-disciplinary conference I'm co-organizing at EMBL Heidelberg bringing together leaders in vascular biology, cardiac research, & bioengineering.
A stellar lineup of speakers w Keynotes:
James Martin & Alessandra Moretti
Opportunities for oral pres from abstracts
The new Department of Functional Genetics at the Max Planck Institute for Molecular Biomedicine is looking for scientists at any level. 👉 mpi-muenster.mpg.de/780013/profil
The Company of Biologists 100 logo to the left and QR code to the right. Portrait of Joachim Goedhart to the left, text to the right 100 extraordinary biologists Joachim Goedhart As one of the most prolific authors on the Node, Joachim Goedhartwrote the Node’s most-read post 'Data Visualization with Flying Colors'. He is an Assistant Professor at the University of Amsterdam, the Netherlands, unravelling G-protein signalling networks in time and space in cells and tissues. #100biologists #biologists100
This week, we are featuring Joachim Goedhart, one of the most prolific authors on @the-node.bsky.social, as an extraordinary biologist. #100biologists
@joachimgoedhart.bsky.social
VE-cadherin RGD motifs are dispensable for cell–cell junctions, endothelial barrier function and monocyte extravasation: Tissue Barriers: Vol 0, No 0 www.tandfonline.com/doi/metrics/...
Interested in research on cell-cell junctions and vascular biology? We are recruiting a PhD student!
werkenbij.amsterdamumc.org/en/vacatures...
Excited to announce that we will be holding another #mechanobiology across scales symposium this year in beautiful Awaji Island #Japan! We have a star-studded lineup of speakers and it's free participation (free accommodation and food!)! Register here: www.igm.hokudai.ac.jp/85th-fujihar...
Is endothelium a type of epithelium?
I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.
This still is one of our favourite experiments!
