1) How do we capture the “golden goose” of interaction proteomics-dynamic, context-dependent PPI networks? Faster data acquisition and deep learning are transforming interactomics. Our review in Molecular Omics highlights recent advances and future directions.

Need for speed: advances in the era of high throughput interaction proteomics Abstract. Protein–protein interactions are central to virtually all biological processes, forming intricate networks that operate in a highly regulated man

2) Great collaborative work with @fabianfrommelt.bsky.social , @afossati.bsky.social and Ruedi Aebersold.
Check out the full paper : doi.org/10.1093/mole...
#Proteomics #MassSpec #Bioinformatics
Happy reading!

A big thank you to the external speakers, the poster presenters from our SFB, our central project Z01 for hosting and all attendees for active participation - the symposium was an engaging and inspiring event!

@fabianfrommelt.bsky.social
@degradomics.bsky.social

The program for our Mini-Symposium on September 23 is now finalized and the registration deadline has been extended to September 5!

Poster slots are still available!

Want to join us?
Just drop a line: sfb1381@biochemie.uni-freiburg.de

@biologyunifreiburg.bsky.social
@degradomics.bsky.social

BEFORE THE BATHROOM SCALE WAS INVENTED, THE ONLY WAY TO WEIGH PEOPLE WAS MASS SPECTROMETRY.

Love today’s #xkcd comic on
#MassSpec
🤣

Yeah Gilles, and the Novartis team were fantastic collaboration partners. They performed the transporter assays for SLC39A8/ ZIP8 (Figure 6E). Showing that the identified interaction partners after knock-down directly affect transport activity of SLC39A8.

We did it! 🎉 The RESOLUTE project is wrapped up. Years of fun collaboration, discovery, and innovation in SLC research. thanks to everyone who was involved! #RESOLUTE #SLC #ScienceTogether

I've noticed this as well, though only on Massive, not in PRIDE. It doesn't make sense to me. I reject it during revisions and say that I can't evaluate the deposited data.

A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.

Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...

Determination of the SLC interactome using MS-based proteomics YouTube video by RESOLUTE

I came across this short, a bit entertaining clip about our SLC-interactome mapping: www.youtube.com/watch?v=FjU5.... Stay tuned - we're in the final stages of wrapping up our paper.

Migration completed. Already connected to many #proteomics scientist accounts ;-)