Rising Burden of Severe Pediatric Coccidioidomycosis: A 25-Year Single Center Study Cases of pediatric coccidioidomycosis have been rising in incidence and severity at our children’s hospital in an endemic area since 2000, including a subs

academic.oup.com/jpids/advanc...

Ecological Role of the Heterotrophic Protist Aurantiochytrium (Labyrinthulomycetes) as a Key Consumer of Viral-Induced Dissolved Organic Matter Following the Lysis of the Red Tide-forming Microalga Heterosigma akashiwo www.biorxiv.org/content/10.64898/2026.04...

Want to annotate a bacterial genome with structures?

@oschwengers.bsky.social bakta and @gbouras13.bsky.social phold got together, and the result is Baktfold: protein annotation across the microbial tree of life using structures

www.biorxiv.org/content/10.6...

#phagesky #microsky #microbiomesky

Deciphering the multidrug resistance paradigm in Candida auris | Antimicrobial Agents and Chemotherapy Candida auris (taxonomically reclassified as Candidozyma auris [1]) is often described as a paragon of antifungal resistance among fungal species. Like the related Candida haemulonii (reclassified as Candidozyma haemuli) complex members, C. auris demonstrates a notably high propensity for antifungal resistance compared to more commonly clinically isolated but genetically distant Candida species. As C. auris has emerged and become more commonly established, concerns around diminishing therapeutic options in an already limited arsenal of antifungal drugs have prompted substantial warnings from clinical and public health authorities (2–4). Our understanding of C. auris antifungal resistance is grounded in early studies that characterized the global spread of this pathogen (5, 6). While the numbers vary across regional reports, nearly 90% of clinical isolates are resistant to at least fluconazole, a widely administered triazole-class drug, while up to 30% of isolates are reportedly also resistant to a drug in at least one other antifungal class. Research in subsequent years has deeply investigated mechanisms and patterns in C. auris antifungal resistance, presenting the opportunity for reexamination to identify therapeutically useful insights (7–9).

Deciphering the multidrug resistance paradigm in Candida auris | Antimicrobial Agents and Chemotherapy journals.asm.org/doi/10.1128/...

Aquatic Bacterial Community Responses to Aquatic Contaminants Revealed by 16S rRNA Metabarcoding in Field‐Based Microcosms This study used sedimentary eDNA analysis and field-based microcosms to assess the impacts of three major aquatic contaminants on bacterial assemblage structure. Our results showed significant but va...

Aquatic Bacterial Community Responses to Aquatic Contaminants Revealed by 16S rRNA Metabarcoding in Field‐Based Microcosms enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/... #jcampubs

WHO assessment of the preclinical antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats Life-threatening invasive and mucosal fungal infections are a major, increasingly complex global health problem. Among all population groups, individuals who are immunocompromised face the greatest ri...

WHO assessment of the preclinical antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats - The Lancet Microbe www.thelancet.com/journals/lan...

Candida albicans steals magnesium and Pseudomonas aeruginosa unleashes resistance - Nature Reviews Microbiology This study uncovers how Pseudomonas aeruginosa acquires colistin resistance in magnesium-depleted environments created by Candida albicans by accumulating unique mutations in the lipid A biosynthetic ...

@hsiehyp.bsky.social and Ian O’Keefe’s recent paper presented as a “Research highlight” in Nature Reviews Microbiology

www.nature.com/articles/s41...

Plasmidome, resistome, and virulence-associated gene characterization of Acinetobacter johnsonii in NASA cleanrooms and a clinical setting | Microbiology Spectrum Acinetobacter johnsonii is increasingly recognized as an emerging human pathogen, with growing evidence of its ability to persist in controlled, high-stakes environments, posing risks as both a persis...

Plasmidome, resistome, and virulence-associated gene characterization of Acinetobacter johnsonii in NASA cleanrooms and a clinical setting | Microbiology Spectrum journals.asm.org/doi/full/10....

Detecting healthcare-associated transmission and antifungal resistance in Candida auris via whole genome sequencing | Journal of Clinical Microbiology Candida auris is a difficult-to-treat yeast that causes invasive infections in vulnerable patient populations. Healthcare exposure is a key risk factor for becoming colonized or infected with C. auris, and infection prevention groups focus on curbing the spread of this organism within the healthcare environment. Whole genome sequencing approaches are key for supporting these efforts, as they can help define clusters of C. auris transmission and can also provide insight into antifungal resistance. Our work provides practical guidance for interpreting genomic data in this setting, helping infection prevention teams respond more effectively to outbreaks and expanding the use of genotypic predictions for antifungal resistance.

Detecting healthcare-associated transmission and antifungal resistance in Candida auris via whole genome sequencing | Journal of Clinical Microbiology journals.asm.org/doi/10.1128/...

very exciting to see aquatic fungi talks at FGC! pity that I missed them. 👍

Thanks for thinking of me. 😉 say hi to Huzefa!
Complicated reasons ... for sure, our path will cross again🤞

Current opinion on the potential role of liposomal amphotericin B in underexplored clinical scenarios | Clinical Microbiology Reviews SUMMARYThe increasing incidence of invasive fungal infections caused by resistant Candida species and molds presents a growing clinical challenge, particularly in immunocompromised patients. While ech...

Current opinion on the potential role of liposomal amphotericin B in underexplored clinical scenarios | Clinical Microbiology Reviews journals.asm.org/doi/10.1128/...

Nice. you are in Asilomar ? I was supposed to attend but cannot manage to go. 🙃

Lineage dynamics of invasive Escherichia coli isolates in the Netherlands from 1975 to 2021: a retrospective longitudinal genomic analysis Escherichia coli is a common cause of invasive infections such as bloodstream and cerebrospinal fluid infections in neonates. Strains positive for the…

Am stoked and thrilled that our latest paper is now out. A longitudinal study of invasive E. coli from children in the Netherlands over 50 years

www.sciencedirect.com/science/arti...

Payment‐based open access is biasing scientific participation from the Global South in ecology Opening access to the products of scientific research is widely considered a key step toward both fairness and better science worldwide. Since the 1990s, different forms of open access (OA) to journa....

Not right! doi.org/10.1002/oik....

AntibioticDB: An Updated and Improved Open-Access Database for the Antibacterial Research and Development Community AntibioticDB (https://www.antibioticdb.com/), originally established in 2017 and since 2021 led by the Global Antibiotic Research & Development Partnership (GARDP), is a freely available database of a...

AntibioticDB: An Updated and Improved Open-Access Database for the Antibacterial Research and Development Community | ACS Infectious Diseases pubs.acs.org/doi/10.1021/...

Comprehensive analysis of air and surface hospital microbiomes uncovers potential hotspots and avenues for transmission of diverse pathogens linked to hospital-acquired infections www.biorxiv.org/content/10.64898/2026.03...

onlinelibrary.wiley.com/share/K3SQTG...

nice work

Antifungal susceptibility testing across fungi: why MICs vary, methods diverge, and what MIC can miss Antifungal susceptibility testing (AFST) is central to antifungal stewardship; however, MIC results can be variable and may require careful interpretation because endpoints can be ambiguous, clinical ...

Antifungal susceptibility testing across fungi: why MICs vary, methods diverge, and what MIC can miss - Clinical Microbiology and Infection www.clinicalmicrobiologyandinfection.org/article/S119...

Global biodiversity and the expanding Tree of Life | PNAS www.pnas.org/doi/10.1073/...

Candida in the lung: Fact, fiction, friend or foe?

Checkout this article I found at PLOS: dx.plos.org/10.1371/jour...

Impacts of climate extremes on plant pathogens, microbiomes and plant health Nature Reviews Microbiology - In this Review, Singh and colleagues discuss the impacts of key climate extremes on soil-borne pathogens, plant microbiomes and host physiology that ultimately...

Xiong, C., Ge, AH., Gao, M. et al. Impacts of climate extremes on plant pathogens, microbiomes and plant health. Nat Rev Microbiol (2026). rdcu.be/e7WVC

Advancing Vibrio genetics: A platform for efficient genomic manipulation Most non-model Vibrio species lack the genetic tools needed for targeted mutagenesis, which limits the ability to functionally characterize newly identified pathways. To address this challenge, we present here efficient, robust methods for genetically manipulating Vibrio species that rely on RecA-mediated homologous recombination and two well-characterized counterselection methods, galactokinase (galK) 2-Deoxy-D-galactose (DOG-2) toxicity and the rpsLR/rpsLS streptomycin susceptibility system, both of which are active across a broad range of Vibrio species. We further characterized two genus-specific conserved promoters capable of driving high-level ectopic expression across all tested species. These promoters were incorporated into two broadly applicable, conjugatively transferable suicide backbones designed to facilitate double homologous recombination. Using these systems, we successfully disrupted polar flagellar motility in multiple Vibrio species and introduced extensive modifications to both flagellar and secretory pathways in V. diazotrophicus. Notably, although the galK system exhibited broader applicability, the rpsL system proved to be more efficient in cases where a streptomycin resistant strain could be generated. We also developed two mobilizable replicative backbones that express pH-stable fluorescent proteins for use within the genus. Collectively, these tools expand the genetic toolkit available for both gene disruption and heterologous gene expression in non-model members of the Vibrionaceae.

Advancing Vibrio genetics: A platform for efficient genomic manipulation | bioRxiv www.biorxiv.org/content/10.64898/2026.03...

Recent Microbial Evolutionary Insights From Metagenomics Abstract. Microorganisms have profoundly shaped Earth's biological and geological history, from the origins of oxygenic photosynthesis to present-day globa

Recent Microbial Evolutionary Insights From Metagenomics url: academic.oup.com/gbe/article/...

brilliant work!

The role of society journals in protecting the scientific record On March 6, 1665, the first scientific journal, Philosophical Transactions (of the Royal Society of London), was launched in the United Kingdom. The public

role of society journals in protecting the scientific record url: academic.oup.com/mbe/article/...

The use of impact factors in the evaluation of researchers has contributed to the distortion of scientific publishing practices and research practices, noted France's CNRS as it walked away from Web of Science, using $$$ saved to promote #OpenScience & #OpenData. www.cnrs.fr/en/update/cn...

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae Abstract. One of the front-line drug classes used to treat invasive fungal infections is echinocandins, which target the fungal-specific beta-glucan syntha

Mutational landscape and molecular bases of echinocandin resistance in Saccharomyces cerevisiae url: academic.oup.com/genetics/art...

Genomic basis for resistance to acute oak decline and mildew infection in English oak www.biorxiv.org/content/10.64898/2026.03...