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Posts by DiegoHarta

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The System That Decides What Science Gets Published Is Breaking Down The peer review system that validates scientific research is trapped in a self-defeating cycle. A new mathematical model shows why—and what comes next.

This is fascinating, and well worth a read.
🧪
www.forbes.com/sites/johndr...

4 weeks ago 18 11 1 0
A slide called: 'Clinical trial registration: Looking back and moving ahead'; on the left are a list of journals listed with their impact factors and number of citations the named article received in that journal. On the right is a plot of numbers of citations vs impact factor.

A slide called: 'Clinical trial registration: Looking back and moving ahead'; on the left are a list of journals listed with their impact factors and number of citations the named article received in that journal. On the right is a plot of numbers of citations vs impact factor.

Exactly the same article (same text, same authors) published in a range of journals at roughly the same time. Number of citations correlates (somewhat) with impact factor of the journal it was published in. Except in Croatia...

1 month ago 23 8 3 3
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Local agricultural transition, crisis and migration in the Southern Andes - Nature In the Uspallata Valley, agriculture was adopted by local populations, as evidenced by genetic continuity from earlier hunter-gatherers to farmers; maize-dependent groups from the same regional p...

¿Cómo llegó la agricultura al sur de los Andes? ¿Por migración o transmisión cultural? Nuestro nuevo paper en @nature.com combina ADN antiguo, isótopos, arqueología y paleoclima para reconstruir más de 2.000 años de historia en Uspallata, Mendoza.
www.nature.com/articles/s41...
Abro hilo🧵
(1/28+)

1 month ago 19 8 1 2
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1/ Three years ago, we completely changed the way we review and publish research articles.

Today, we’re taking a look at how it’s going and what’s next.

buff.ly/aHwYNIE

1 month ago 19 11 1 1
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Many journals require data and code sharing. Yet code is still rarely shared and datasets are often hard to reuse.

Our new paper introduces the @sortee.bsky.social guidelines for data & code quality control in ecology & evolution, developed by 26 experienced data editors.

📄 doi.org/10.24072/pcj...

1 month ago 88 62 1 1

RE: https://ecoevo.social/@marcrr/115656029348896562

Update of our preprint on detecting selection on regulatory sequences! We notably added an analysis for human, where the likelihood test per ChIPseq peak lacks power.
There is a similar problem with branch-site dN/dS tests, and a solution has […]

1 month ago 4 2 1 0
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Formalizing our commitment to code sharing In support of open science, PLOS Biology routinely asks authors to openly share their research code before publication. We are now formalizing this practice with a mandatory code sharing policy and…

In support of #OpenScience, we routinely ask authors to openly share their #research #code before publication.

We are now formalizing this practice with a mandatory #CodeSharing policy and clarifying what we mean by code sharing.

1 month ago 49 25 1 2

Huge spectrum of views on this. At one end, visions of a living 'article of the future' with embedded data in wondrous new formats. At the other, "just a PDF".

What is most interesting to me is that someone's position on that spectrum does not correlate with how tech savvy they are. 1/n

1 month ago 9 2 2 2
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Major Chinese funder to stop paying fees for 30 pricey open-access journals Move comes amid effort to grow the country’s own journals

Are #openaccess fees that some journals charge authors too high? The Chinese Academy of Sciences, the world’s largest research institution, reportedly thinks so and plans to stop funding some, a move that could shake up #scientificpublishing. @science.org www.science.org/content/arti...

1 month ago 49 33 2 5
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SORTEE Webinar: On what makes good sharable and reproducible R code, how to do it, and why it’s good for science For this month's SORTEE webinar, Dr. Dax Kellie from the Atlas of Living Australia will present on good, sharable, and reproducible R code in science

Coming up in March! Join @sortee.bsky.social for a webinar with @daxkellie.bsky.social on good, shareable, and reproducible R code - register here: events.humanitix.com/sortee-webin...

1 month ago 23 23 0 1
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Post doc position in Evolutionary biology and bioinformatics - work environment: This postdoctoral position will be supervised by Aline Muyle and hosted at the Institute of Evolutionary Sciences of Montpellier (ISEM), within the CHANGE department and the Plant ...

I am hiring a Postdoc (18 months contract in Montpellier, France) to study how polyploidy affects sex chromosomes in the plant Silene latifolia, using bioinformatic analyses of RNA-seq and DNA-seq data. Deadline for applications March 24th. euraxess.ec.europa.eu/jobs/412961

1 month ago 18 36 0 0
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Chromatin spatial analysis by METALoci unveils sex-determining 3D regulatory hubs - Nature Structural & Molecular Biology METALoci, a new three-dimensional genome computational tool, reveals a major rewiring of regulatory interactions during sex determination. By combining this method with transgenic models, the authors ...

🔊💥 How is sex determined? How is it encoded in the #3Dgenome?

Read all about it in our last paper!
www.nature.com/articles/s41...

It’s been looong but feels satisfying to see this finally out.

(With CapelLab, @dariloops.bsky.social Lab and @mamartirenom.bsky.social Lab)

🧵👇

1 month ago 22 8 1 1
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Have you ever wondered 🤔... Does phenotypic variance respond to environmental perturbation? Does it have a genetic basis? Are mean and variance regulating loci exposed to different selection pressures? These and more questions are explored in our new preprint 🔥

www.biorxiv.org/content/10.6...

1 month ago 88 49 2 4

Up to what degree of interspecific genetic distance is it possible to form viable and fertile hybrids? A strange species of paramecium breaks the record:

www.biorxiv.org/content/10.6...

1 month ago 17 7 0 0
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PCI Webinar Series - Peer Community In The PCI webinar series is a series of seminars on research practices, publication practices, evaluation, scientific integrity, meta-research, organised by Peer Community In

We are thrilled to announce Paolo Crosetto's presentation titled "The Drain of Scientific Publishing: Why Publishing Has Become a Challenge for Science and How It Can Be Improved" in our upcoming PCI Webinar on March 19th at 4 PM (GMT+1)!! 🤩
To learn more and sign up, please visit buff.ly/bxYWPCz

2 months ago 7 4 0 0
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Mi gente latino!
Ya llegó ya está aquí. La primera reunión de Biomoleculas antiguas en Latinoamerica patrocinada por el @official-smbe.bsky.social . Reserven la fecha y estén al pendiente de las fechas importantes. Mas info en nuestra pagina web smbeperu.github.io/SMBEperu-esp/

2 months ago 11 10 1 2
Structural Variants ESEB Special Topic Network ESEB Special Topic Network

🧬We are launching STRiVE, a @eseb.bsky.social Special Topic Network on the evolutionary role of structural genomic variation.

🗓️Std:
29/04: Online seminar w/ L. Rieseberg
8-10/07: Kick-off in Porto

Join us: structuralvariantsstn.github.io #Evolution #Genomics #StructuralVariants #Biology #PopGen

2 months ago 22 17 0 0

Estén el pendiente y reserven la fecha 🤩🧬🇵🇪

2 months ago 1 3 0 0
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To add one thing: if you have the data to run both classic dN/dS tests and MK tests, choose the latter. dN/dS tests are blind to positive selection in the important, constrained proteome, while MK test will work regardless of constraint, if DFE well estimated.
#evolution #adaptation #popgen

2 months ago 13 6 0 0

🌺 New preprint out with John Pannell and @charlesmullon.bsky.social ! 🌺

We show that selection broadly favours a form of plasticity for the selfing rate where individuals adjust their mating behaviour to their condition — their overall vitality owing to their genetic background and environment. ⤵️

2 months ago 19 11 0 0

Congratulations to everyone involved!

Below is the link to the article.

@luisapallares.bsky.social @nedabarghi.bsky.social @rachaelabay.bsky.social @ahancock.bsky.social @genmig.bsky.social @meauxjuliette.bsky.social @abepalmer.bsky.social @kjschmid.bsky.social @mpi-evolbio.bsky.social

2 months ago 16 7 0 2
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The evolution of tandem repeat sequences under partial selfing and different modes of selection - Heredity Heredity - The evolution of tandem repeat sequences under partial selfing and different modes of selection

New paper with @vsudbrack.bsky.social. Using pop gen modelling, we show that partial selfing makes selection on tandem repeats more efficient, reducing the associated load across different scenarios. Thanks to @snsf.ch @dee-unil.bsky.social @fbm-unil.bsky.social !

www.nature.com/articles/s41...

2 months ago 17 10 0 1

If you are a scientist, working on biology, wondering where to submit your manuscript given the current issues with the academic publishing system, check out wheretopublish.github.io!
We did this thinking change is possible. Let’s make it happen!

2 months ago 8 7 0 0
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A 5500-year-old Treponema pallidum genome from Sabana de Bogotá, Colombia Treponematosis, a bacterial infection caused by Treponema pallidum subspecies and T. carateum (yaws, bejel, syphilis, pinta), has afflicted humans for millennia. Despite paleopathological evidence and...

Treponemal diseases might have been with us much longer than previously thought! In our recent study, we used ancient DNA to reconstruct a 5,500-year-old 𝘛𝘳𝘦𝘱𝘰𝘯𝘦𝘮𝘢 𝘱𝘢𝘭𝘭𝘪𝘥𝘶𝘮 genome, revealing a previously unknown divergent subspecies.
You can check it out here:
www.science.org/doi/10.1126/...

3 months ago 31 14 1 0

The next step in a great scientific adventure led by @mbrasovives.bsky.social on amphioxus evolution: population genomics of a species with 3% heterozygosity! Read the thread and the preprint 😁

3 months ago 3 2 0 0

Amphioxus strikes again! Check out our new preprint led by the wonderful @mbrasovives.bsky.social ! Thread and link below.

3 months ago 3 1 0 0
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The highly heterozygous European amphioxus (Branchiostoma lanceolatum) at the edge of panmixia Amphioxus are small marine chordates that have broad ecological ranges, yet as adults form local settlements and exhibit limited mobility. Genomic surveys of two amphioxus species have suggested that they rank among the most genetically diverse metazoans. Here, we present the first accurate assessment of genomic diversity in the European amphioxus ( Branchiostoma lanceolatum ) and investigate the processes underlying this diversity. We leverage high-coverage whole-genome sequencing data from multiple individuals sampled at two geographically distant Atlantic and Mediterranean locations. Consistent with previous estimates in other amphioxus species, we measure exceptionally high genomic diversity, with an average heterozygosity of 2.73% in B. lanceolatum . Despite the large geographic separation between sampling sites, population differentiation is minimal, indicating extensive gene flow among distant adult settlements. Phylogenetic analyses combined with population genetic simulations confirm that this elevated genomic diversity is primarily driven by a large effective population size. Although adult amphioxus have limited mobility, our results indicate that long-distance larval dispersal mediated by ocean currents is sufficient to generate a near-panmictic population structure across their broad ecological range. ### Competing Interest Statement The authors have declared no competing interest. Swiss National Science Foundation, 207853 Agence Nationale de la Recherche, ANR-21-CE13-0034

1/7 🧬 New preprint!

What is it like to have one of the highest genomic diversities among metazoans?

🔗 www.biorxiv.org/content/10.6...

3 months ago 14 11 1 3
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We've got ISSUES. Literally.

We scraped >100k special issues & over 1 million articles to bring you a PISS-poor paper. We quantify just how many excess papers are published by guest editors abusing special issues to boost their CVs. How bad is it & what can we do?

arxiv.org/abs/2601.07563

A 🧵 1/n

3 months ago 508 315 17 49
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No deal with #SpringerNature
Switzerland has been without an agreement since 1.1.2026. Consequently, the SNSF is pausing funding for #OpenAccess articles in these journals.

This joint measure with the 🇨🇭 higher education institutions strengthens our negotiating position.

ℹ️ Info : sohub.io/a8rh

3 months ago 13 6 1 1