Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.social
LSHTM: where your 'what ifs' become your reason why...
This #WorldHealthDay find out how you could become part of our community, tackling the complex challenges of global & #PublicHeath with clarity, compassion and conviction.
Join us: explore our programmes: www.lshtm.ac.uk/study?utm_so...
Latest from the lab!
Between clinical S. aureus, most gene transfer mechanisms are blocked, yet lateral transduction remains highly efficient.
Restriction modification-defective strains act as gateways for horizontal gene transfer, enabling DNA flow across populations. rdcu.be/fbNQK
We've been we've been working on this for quite a while now (hopefully published soon). Grateful to @proftracypalmer.bsky.social for concinving me & @lislowe.bsky.social that mycobacteria produce inter-bacterial toxins. Team science, led by @sambenedict5.bsky.social www.biorxiv.org/content/10.6...
Graphic with white text reading: New programme, MRes Infectious & Tropical Diseases on a royal blue background. An inset image shows two female researchers in white coats and purple gloves standing in a laboratory placing specimen vials into a machine.
Introducing the #MRes in Infectious & Tropical Diseases
LSHTM’s exciting new #postgraduate degree putting you at the heart of our world-leading research:
→ Learn from the experts
→ Build your network
→ Study in a unique environment
Applications now open 👉
www.lshtm.ac.uk/study/course...
@lshtm.bsky.social launches its new MRes in Infectious & Tropical Diseases, a research-focused Master’s. It is based within LSHTM’s Faculty of Infectious & Tropical Disease. Strong option for intercaled students.
More details here:
www.lshtm.ac.uk/study/course...
This youngsters..
Light blue graphic with black text reading: "Meningitis is now very rare in the UK in the era of vaccination but there are still cases every year." Eliza Gil, Clinical Lecturer, LSHTM
BREAKING NEWS: Deadly outbreak of #meningitis B in UK
LSHTM experts discuss latest situation, including access to #MenB #vaccines
More: www.lshtm.ac.uk/newsevents/n...
#PublicHealth
Indeed!
👋We welcomed Director-General of @who.int & LSHTM alumnus @drtedros.who.int who returned to LSHTM this week to discuss how we can strengthen collaborations to tackle major #GlobalHealth challenges.🌍
👉 www.lshtm.ac.uk/research/cen...
Great @imibirmingham.bsky.social seminar by the brilliant @josebengoechea.bsky.social who has uncovered another cool and important mechanisms in Klebsiella pneumoniae virulence (no spoilers because unpublished data)
🔬 New work from the Mazel Lab engineers programmable conjugative plasmids to selectively target MDR bacteria and the resistance plasmid pOXA-48, blocking its spread in complex communities.
✍️ @amazeld.bsky.social & coll. @pasteur.fr
📖 shorturl.at/GZdJu
#MicroSky #AntibioticResistance #Conjugation
I am rather worried that this government not only will actively fail UK universities but also screw over one of the gems of UK economy - science and life science, particularly.
Will UKRI's funding buckets shore up UK research? share.google/B92vQ7E6nEOK...
👋LSHTM offers #scholarships to tackle barriers to education for students from all backgrounds.
Check out our First and Next Generation Scholarships for home fee students & those interested in distance learning MSc programmes.
Apply by 27 March 2026👉 www.lshtm.ac.uk/study/fees-a...
Virtual webinar on safe microbiome perturbations focusing on gut microbiome and probiotics, scheduled for 26 February 2026.
Join us this Thursday for our online seminar series, Safe Microbiome Perturbations. Featuring a live discussion on 'Gut Microbiome and Probiotics.' Register now: https://microb.io/3OBhVPs
#GutMicrobiome #WebinarSeries
Insights into how #Staph aureus adapts to the bovine host by unlocking nutrients from the dairy niche. Great work by Amy Pickering, Jamie Gorzynski and others in the group. Bacterial metabolic remodeling by convergent evolution after a host switch.|Science Advances www.science.org/doi/10.1126/...
On this plus side, the number of billionaires in the UK rose from 15 in 1990 to 165 in 2024.
Huzzah!
A perfect example of how to damage irreversibly a funding system that was eorking in a reasonable manner. Instead of increasing responsive mode funding, the option chosen is centralization of the budget on UKRI to deliver....nothing...while damaging ECRs.
#WeekendRead #MicrobiotaPower! Tsai, @diehllab.bsky.social &co show @ Science Immunology that E. coli flagellin is recognized by TLR5 on intestinal epithelial stem cells to recruit gut protective CCR2+ monocyte-derived macrophages, decreasing colitis! #IBDs doi.org/10.1126/sciimmunol.adr4057
Milestone of the lab...10000 strains in our collection!
#Klebsiella infections are a serious & growing #PublicHealth threat
For #AntimicrobialAwarenessWeek, @josebengoechea.bsky.social discusses the dangers of bacterial infections, antimicrobial resistance & the global efforts to tackle it. @lshtmamrcentre.bsky.social
www.lshtm.ac.uk/newsevents/e...
For anyone interested in doing a PhD at the interface of microbiology and immunology focusing on how AMR pathogens subvert host defenses...you may consider applying to our MRC LID DTP project in which we will explore how Klebsiella hijacks the immune checkpoint PD-L1 mrc-lid.lshtm.ac.uk/apply/
So happy to share this! Bacteriocins were first discovered over 100 years ago, but what do they actually do? We look at >1000 bacteriocin plasmids and find links to virulence and antimicrobial resistance, and frequent bacteriocin sharing in Enterobacteriaceae.
www.nature.com/articles/s41...
Government has published one of those quiet but important documents that might get overlooked as it is not 'newsy'. The headline finding is that £1 of public R&D investment generates £8 in net economic benefits for the UK over the long term
www.gov.uk/government/p...
Genome-wide screen to identify Escherichia coli gene knockouts hypersensitive to trimethoprim and chloramphenicol. Top left: Schematic showing the screening strategy for identifying hypersensitive gene knockouts from the Keio mutant library. All mutants were cultured in LB and LB supplemented with trimethoprim (TMP) and chloramphenicol (CMP) at their respective IC50s. Top right: Distribution of drug-susceptibilities of Keio mutants grown in indicated growth media obtained after normalizing the growth of each mutant to wild type (set to 1). Mean ± S.D. derived after fitting each distribution to a Gaussian function are shown. Bottom left: Analysis of gene functional categories for hypersensitive mutants compared with the frequency of genes in each category encoded by E. coli K-12 MG1655. Percentage of the total in each case is provided above each bar. Bottom right: Comparison of hypersensitive mutants identified in the trimethoprim and chloramphenicol screens shown as a Venn diagram. Representative genes from each set are named and gene names are colored by functional categories.
Intrinsic resistance pathways & #ResistanceBreaking. Study shows that inhibiting efflux pumps & cell envelope biogenesis sensitizes #bacteria to #antibiotics, but rapid evolutionary recovery may limit long-term effectiveness of resistance-breaking strategies #AMR @plosbiology.org 🧪 plos.io/4huAtvo
Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei
@sydneylmiles.bsky.social @katholt.bsky.social
🙏to transformative collaborative effort
www.nature.com/articles/s41...
New paper with my (amazing) friend and mentor @jrpenades.bsky.social
Really looking forward to see what plasmid aficionados think of this one!!
With @asantoslopez.bsky.social @wfigueroac3.bsky.social Akshay Sabins and others
www.cell.com/cell-reports...
#WHO report shows rising #antibiotic resistance in common bacteria
@katholt.bsky.social & @josebengoechea.bsky.social explain resistance worryingly high in #Klebsiella & E.coli as 1 in 6 lab-confirmed #bacterial infections in 2023 shown resistant to antibiotics.
www.lshtm.ac.uk/newsevents/n...
My nose must be riddled with S. aureus then 🫠
