Mazal tov!

A bacterial toxin disarms gut defenses against inflammation Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice

New discovery in ulcerative colitis: a bacterial toxin that kills macrophages and increases inflammation, which could be the foundation for a new treatment
science.org/doi/10.1126/...
science.org/doi/10.1126/...
@science.org

Intracellular competition shapes plasmid population dynamics From populations of multicellular organisms to selfish genetic elements, conflicts between levels of biological organization are central to evolution. Plasmids are extrachromosomal, self-replicating g...

Hot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/
www.science.org/doi/10.1126/...

A bacterial toxin disarms gut defenses against inflammation Macrophage-toxic bacteria from patients with ulcerative colitis worsen gut inflammation in mice

I'm happy to share a perspective that
@soniamodilevsky.bsky.social
and I wrote about a new and exciting paper in @science.org
with big implications for IBD.
Check it out:
A bacterial toxin disarms gut defenses against inflammation | Science
www.science.org/doi/10.1126/...

Additional talks this fall include @mucusman.bsky.social, Selena Sagan (hosted by @uwmadisonmdtp.bsky.social), @teralevin.bsky.social, @csdetweiler.bsky.social, Jan Rehwinkel, Sung Chul Park, Claire O'Leary, Sean Crosson, @torreslab.bsky.social, and Patricia Champion

Thank you Marc 🙏🏻

Toda ❤️

Toda Ira 💖

Toda Asaf ❤️

Toda 💗

Thank you Yasin. We sure do.

Highly recommend 👇🏻

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Toda Danny 🙏🏻

Thank you 🙏🏻

Toda ❤️

a man is writing prof on a blackboard ALT: a man is writing prof on a blackboard

🚨While the world is burning down around us, I'm happy to share that I've been promoted to Associate Professor with tenure. Though this is considered a personal achievement, it was only possible due to the wonderful trainees in the lab, who carried me here❤️.

This was not our conference, please redirect to the appropriate advisory committee. beneficialmicrobes.events/advisory-com...

This is unacceptable. A total disgrace. Shame on the organizers. Leave science out of it! I am appalled to see this in the microbiology community 🦠

Total disgrace!

Just a few spots remaining for the GRC Salmonella Biology and Pathogenesis meeting to be held in August. The final program is now online. www.grc.org/salmonella-b...
Apply now to hear about the latest scientific discoveries about Salmonella, meet up with old friends, make new friends......

One of the best performances in a final

A coordinated cellular network regulates tolerance to food @nature.com @annarudnitsky.bsky.social @kedmiranit.bsky.social
www.nature.com/articles/s41...

Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1

Development of a replication competent murine norovirus reporter system Author summary Colloquially known as “the stomach bug,” human norovirus is a leading cause of foodborne illness worldwide. Despite its prevalence, there are no approved therapeutics or vaccines agains...

Excited to share the work of Mikayla Olson in the lab making a replication competent reporter virus for murine norovirus. journals.plos.org/plospathogen...

Secretory IgM regulates gut microbiota homeostasis and metabolism - Nature Microbiology Rainbow trout with depleted secretory IgM reveal interesting insights into the elusive role of this immunoglobulin in maintaining gut microbiota.

Our latest paper is now out. A long standing collaboration with the Sunyer lab where our teams show the requirement for secretory IgM in the gut mucosa to control microbiota homeostasis and metabolism. Enjoy! #sIgM #mucosalimmunology www.nature.com/articles/s41...

Tomorrow I will host Will Ratcliff @wcratcliff.bsky.social in the virtual microbiology journal club.
Title: "Exploring the origin of multicellularity in real time: what we've learned from 10,000 generations of laboratory evolution"

link below -

Unconventional secretion of PARK7 requires lysosomal delivery via chaperone-mediated autophagy and specialized SNARE complex | PNAS PARK7/DJ-1, a redox-sensitive protein implicated in neurodegeneration, cancer, and inflammation, exhibits increased secretion under stress. We prev...

Secretory autophagy strikes again! 🧪
www.pnas.org/doi/10.1073/...