Moral of the story: If your data take you to the magical land of #gdTcells and you're not an expert, reach out to a #gdTcell afficionado. We're a pretty friendly bunch with a great monthly #gdTcellclub webinar + biannual meeting (Poland 2027!). Find us here: @forum-gd.bsky.social

/✌️2025

We close out 2025 with a review by @ananya-p.bsky.social & @tingtingli1.bsky.social in @gutmicrobes.bsky.social discussing the influence of the #microbiota on #gdTcell compartments within the gut, since populations and function differ in the #epithelium and lamina propria. 1/n

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...

Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv:
www.biorxiv.org/content/10.6...

It’s a #gdTcell flavored #MucosalMonday! @saraalonsomera.bsky.social & I chat about the magic of our favorite cell type and our recent paper elucidating the role of the microbiota in driving gd IEL regulatory function on this month’s @societymucosalimm.bsky.social podcast.
@sinaiimmuno.bsky.social

She’s got her white coat, so now @ananya-p.bsky.social is an official PhD student @sinaiimmuno.bsky.social ! That’s how that works, right? More #gdTcell magic to come! 😁

Frontiers | Cord blood innate-like T cell responses in neonates born to healthy women and women living with HIV Innate-like T cells (ILT), including γδ T cells (Vδ2s), Natural Killer T cells (NKTs) and Mucosal-associated Invariant T cells (MAITs), integrate innate and ...

Our paper on cord blood innate-like T cell responses in HIV-exposed but Uninfected (HEU) infants is (finally) out! 🎉😅😄 Writing was slowed due to my constant diving into #flowcytometry, #rstats and #gdtcell rabbit-holes. See how these all converged below. 1/n

www.frontiersin.org/journals/imm...

Thanks for spreading the love of #gdTcell biology!

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Congrats to all the awardees. It was such a delight to welcome the community to #gammadeltatoronto #gd2025 and see these bidding scientists in action! Thanks @aai.org for supporting #GDTcell research

As expected, #gd2025 is as delightful as ever! Glad I could bring Irving & @saraalonsomera.bsky.social to hang out with our #gdTcell crew including @sarinaravens.bsky.social, @coffeltlab.bsky.social, @immunowolf.bsky.social, and Julie Jameson 🤩 Miss you @lydialynch.bsky.social!

Day 2 chairs of #gammadeltatoronto starting us off. Up first, a beautiful talk by Joonsoo Kang about the 40y of #GdTcell development discoveries.

Lauren standing in front of her poster on γδ T cells in CVID.

Had a fabulous time presenting on day 1 of the #gdtcell conference in Toronto! Was a fantastic poster session with lots of discussion and interest! @forum-gd.bsky.social

Really excited to be at the 11th Intnl #GdTcell conference in Toronto this week. Beautiful welcome address by the organizers followed by a smashing keynote talk by Prof. Erin Adams about the not so unifying theory of GDT ligand recognition. #gammadeltatoronto @forum-gd.bsky.social

Here we go!!!

Congrats to @ananya-p.bsky.social on her outstanding Master’s defense on #gdTcell migration! 🍾🎉 We’re looking forward to another couple of years with Ananya as she takes on the new role of senior grad student @sinaiimmuno.bsky.social 😁

There are few things better than celebrating milestones with your wonderful mentees! Congrats to @saraalonsomera.bsky.social & @nbgolovchenko.bsky.social on their graduation today. These two started during #COVID lockdown, moved to #NYC and will have made lasting contributions to the #gdTcell field🤩

#APS2025 kitten break. We may need a new lab mascot for our collective mental health 😍 Thoughts on #gdtcell or #IEL -related names? @forum-gd.bsky.social

If you missed @ananya-p.bsky.social’s excellent flashtalk on #gdTcell migration at #APS2025 GIL Forte Session, catch her repeat performance at the GIL Trainee Symposium or her poster on Saturday. #GIsky #Gastrosky #GIresearch

New platform, same mission: figuring out if the sky is actually bluer—or just algorithmically different. 👀
If you're in the #IBD, #gdTcell, or #GIresearch world, help me reconnect! Would love to rebuild my research circles over here.

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

Check out our new #preprint to learn how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype 🤩

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

@sinaiimmuno.bsky.social just gained a rockstar #PhD student with the acceptance of @ananya-p.bsky.social! Come see why we’re so lucky that Ananya will be joining us for a few more years at the APS Summit. She’ll be presenting two flashtalks (#GIL Trainee Symposium & Forte) on #gdTcell #migration 😍

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

📚NEW #gdTcell PAPER ALERT! Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis | Science Immunology
Bluetorial coming soon!!! #gastrosky #GIsky #IBDsky @nbgolovchenko.bsky.social @squeakyanimal.bsky.social @andrewfong.bsky.social

Congratulations to Dr. Sara Alonso on a spectacular defense! 👏 🍾 Sara is a powerhouse of #gdTcell #immunometabolism data in the lab. We can’t wait to share the #preprint of her thesis work on #gdTcells and #microbiota with you later this week. @sinaiimmuno.bsky.social

A great opportunity in #gdTcell biology in a fantastic (and very fun) lab!

Pls RT. The organizers of #GDTcellclub webinar series are looking to welcome new #GDTcell scientists to join the team. Pls comment below to be added to the upcoming informational meeting. Looking for driven grads/postdocs/faculty to join us in keeping this platform alive. @forum-gd.bsky.social

two Mason jars of apple chutney with a light green silk scarf tied as a bow around it and a holiday greeting card in the background.

The world knows Prof Emeritus Cynthia Baldwin as one of the most prolific bovine #GDTcell Immunologists. I know her as my PhD mentor, who sends me home made apple chutney over holidays. ☺️ .. Marked with date and a list of ingredients, as a good Immunologist would. Spoonful of love+cheer, every bite.

γδ T cells for cancer immunotherapy: A 2024 comprehensive systematic review of clinical trials Despite a substantial increase in funding, activity, and interest, the overall picture regarding outcomes of γδ T cell immunotherapeutic trials for ca…

This is a superb compilation review of up to date #GDTcell based clinical trials from Marta Barisa et al. at UCL.

@forum-gd.bsky.social

www.sciencedirect.com/science/arti...

Welcome to our new lab manager, Noah Grunberg! Noah joins us following grad studies at #BU and has quickly developed enthusiasm for #gdTcell #signaling. Looking for #gdTcell-flavored mouse lines in North America because they're all frozen down at JAX now? Noah's your guy 😆 @sinaiimmuno.bsky.social

Over the next few days, we're going to introduce you to some new lab members and #gdTcell devotees 😍 Say hello to
@sayrakinestorm.bsky.social! An @einsteinmededu.bsky.social grad, Sayra is excited to delve into #gdTcells and #neuroinflammation in #IBD during her #postdoc @sinaiimmuno.bsky.social
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