Delighted to share our new #preprint on #mastcell desensitization on @biorxiv-immuno.bsky.social

We show that #mastcell #desensitization involves #IgE internalization and induces distinct #immunoregulatory #transcriptional program linked to #immune regulation.

www.biorxiv.org/content/10.6...

CD101: A versatile molecule associated with immunoregulatory and antimicrobial functions CD101 exhibits negative costimulatory, immune-modulatory, inflammatory, and antimicrobial functions dependent on the T lymphocyte and myeloid cell subset o

Jochen Mattner @fau.de provides a comprehensive Review of #CD101 - "CD101: A versatile molecule associated with #Immunoregulatory and #Antimicrobial functions"

DNA Damage-driven Inflammatory Cytokines: Reprogramming of Tumor Immune Microenvironment and Application of Oncotherapy

This comprehensive review explores the interplay between the #DNADamage response and #CytokineSignaling in #Tumors, highlighting their dual #Immunoregulatory roles and therapeutic implications. #medsky
Read more: link.springer.com/article/10.1...

Protective microglia subtype offers potential new therapeutic pathway in Alzheimer’s disease – BioNews Central Lowering transcription factor PU.1 increases protective microglia with immunoregulatory receptors that suppress brain inflammation and support cognition in Alzheimer’s disease models.

Lowering #TranscriptionFactor PU.1 increases protective #microglia with #immunoregulatory receptors that suppress #BrainInflammation and support #cognition in #AlzheimersDisease models.
#PU1 #Neuroinflammation #ImmuneRegulation

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

Check out our new #preprint to learn how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype 🤩

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mice harboring a microbiota-specific hyperproliferat...

If you read our #ScienceImmunology paper and want to know how the #microbiota induces #CD39 to promote a #gdTcell #immunoregulatory phenotype, check out our new #preprint!

IL-12 drives the expression of the inhibitory receptor NKG2A on human tumor-reactive CD8 T cells Nature Communications - Effective strategies to enhance T cell anti-tumor cytotoxicity are pivotal to improve treatment outcomes. By analyzing tumor samples from patients with head and neck or...

Underscoring the complexity of #anticancer immunity, Dr Fesneau in the Duhen lab @ #EACRI showed that #IL-12, while driving CD8 T cells to CTL, also drives up-regulation of #immunoregulatory #NKG2A on human #tumor-reactive #CD8.
rdcu.be/d0A7V. Very nice work by a great group #FinishCancer

🎉👏 Welcome Melanie Tichet, our newly established FCI group leader #Tumorimmunology. Mélanie & her lab investigate #immunoregulatory mechanisms in the #tumormicroenvironment and resistance to therapy.
More ➡️ georg-speyer-haus.de/en/staff/tic...