No human study has measured diet, bile acids, and Th17/Treg balance simultaneously in IBD. A 2026 JCC mouse study and a 2022 Nature paper converge on Treg expansion — via BHB, via bile acids. This preprint proposes a cross sectional test of diet on both.
#MucosalImmunology #OpenAccess
#IBD

Milk-derived osteopontin influences the composition of the intestinal intraepithelial lymphocyte compartment Abstract. Osteopontin is a protein with many physiological roles widely expressed by many cell types, tissues, and bodily fluids, including breastmilk. The

Read the latest #SMIMemberPaper from Danyvid Olivares-Villagómez and colleagues in ImmunoHorizons on breast milk derived osteopontin in the development of IELs. Read more here: academic.oup.com/immunohorizo...

#MucosalImmunology #Immunology

Nasal CD4⁺ tissue-resident memory T cells provide cross-protective immunity to #influenza. New study from Nimitha R. Mathew, Davide Angeletti @angelettilab.bsky.social and colleagues (University of Gothenburg): rupress.org/jem/article/...

#Virology #MucosalImmunology #InfectiousDisease #HostDefense

Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity. New study from Patrycja M. Forster, Christoph S.N. Klose and colleagues (Charité – Universitätsmedizin Berlin)
rupress.org/jem/article/...

#MucosalImmunology #Inflammation

CD4 tissue resident memory cells are established and persist in the upper airways after #influenza infection and protect from re-infection with drifted strains. New study in @jem.org by Nimitha Mathew et al. @angelettilab.bsky.social: rupress.org/jem/article/...

#Virology #MucosalImmunology

CD4 tissue resident memory cells are established and persist in the upper airways after #influenza infection and protect from re-infection with drifted strains. New study by Nimitha Mathew et al. @angelettilab.bsky.social: rupress.org/jem/article/...

#Virology #MucosalImmunology #InfectiousDisease

UMass Chan researchers shed light on how inflammation in GI tract rewires enteric nervous system Published in the Journal of Experimental Medicine, the UMass Chan study revealed that intestinal inflammation changes how nerves are arranged in the intestine.

IBD doesn’t just inflame the gut—it rewires it. New research by Milena Bogunovic, MD, PhD, of UMass Chan, published in @jem.org, shows how inflammation modifies the enteric nervous system, often referred to as the “second brain”: direc.to/o2Xp

#IBD #MucosalImmunology #muscosal #immunology

Registration is now open for the 2026 SMI Principles of Mucosal Immunology Course, taking place in-person at #ICMI2026, Monday, July 13. Enjoy sessions focusing on both scientific and career development topics.

Register now and save! bit.ly/4by83iD

#MucosalImmunology

The next submission window for SMI's Technique-Sharing Travel Grant closes in 1 week - Tuesday, March 31. Don’t miss this opportunity to learn a new technique to bring back to your lab from fellow mucosal immunologists.

Apply now! bit.ly/3I8TfIn

#MucosalImmunology

Epidermal growth factor receptor controls sex differences in lung type 2 responses to inhaled allergen Female mice have exacerbated, EGFR-dependent lung type 2 immunity when exposed to inhaled house dust mite throughout sexual maturation.

Read the latest two #SMIMemberPaper by Clare Lloyd and colleagues in Science Immunology and Journal of Allergy and Clinical Immunology.

Read here:
www.science.org/doi/10.1126/...
www.jacionline.org/article/S009...

#MucosalImmunology #Immunology

It’s #MucosalMonday! New episode coming next week; in the meantime, check out episode 14, "MDSCs at the Vaginal Mucosa."

Listen here -> bit.ly/4lxNC7F

#MucosalImmunology #Immunology

#Inflammation rewires the enteric nervous system through neurogenic #monocyte recruitment, say Sravya Kurapati, Changsik Shin, Krisztina Szabo, Milena Bogunovic @umasschan.bsky.social and colleagues: rupress.org/jem/article/...

#MucosalImmunology #Neuroinflammation #IBD

Did you miss the deadline to submit an abstract for ICMI 2026? Don't worry! You still have the opportunity to submit a late-breaking abstract for consideration to present a poster.

Submit your abstract here: bit.ly/4lnTKQT

#ICMI2026 #MucosalImmunology #Immunology

Sensing of metabolic signals via GPR183 promotes occupation of lung #macrophage niches by #monocytes. New study from Laura Bub, Elza Evren, Stijn Verwaerde, Thomas Marichal, Bart Lambrecht, Tim Willinger @ki.se et al.: rupress.org/jem/article/...

#Metabolism #MucosalImmunology #inflammation

Mucosal vaccination in mice provides protection from diverse respiratory threats Traditional vaccines target specific pathogens, limiting their scope against diverse respiratory threats. We describe an intranasal liposomal formulation combining toll-like receptor (TLR) 4 and 7/8 l...

Link: www.science.org/doi/10.1126/...

#ELINE #EarlyLifeImmunity #Vaccines #MucosalImmunology #BCG #TrainedImmunity #Immunology

(7/7)

An exclusive SMI member benefit is now underway! Don't miss your chance to acquire techniques from fellow mucosal immunologists through the SMI Technique-Sharing Travel Grant.

Submit your application here -> bit.ly/3I8TfIn

#MucosalImmunology #SMI #Immunology #TechniqueSharing

New study from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity #inflammation

New study @jem.org from the labs of Willinger, Lambrecht, Marichal and colleagues found that #cholesterol metabolites recognized by the receptor GPR183 attract #monocytes to repopulate depleted lung #macrophage niches. rupress.org/jem/article/...

#Metabolism #MucosalImmunology #InnateImmunity

Serum IgG Response to a Conserved Domain of Commensal Flagellins Predicts Future Risk of Crohn’s Disease in First-degree Relatives Elevated antimicrobial antibodies have been reported up to 6 years before diagnosis of Crohn’s disease (CD), but the specific antibody response is unclear. Here, we characterized the antimicrobial ant...

Read the latest #SMIMemberPaper by Croitoru and colleagues in @AGA_CGH. The CCC-GEM Project has found a new predictor for #Crohns in anti-flagellin IgG antibodies in first degree relatives of Crohns patients. Read more here: www.cghjournal.org/article/S154...

#MucosalImmunology

LAST CHANCE to submit your abstract for ICMI 2026!
*SMI members receive 100% off abstract submission fees (email info@socmucimm.org to get your discount code).

Submit here: bit.ly/4szJDfe

#ICMI2026 #MucosalImmunology

Invest in your future! The SMI Mentorship Program is now accepting applications.

Learn more and apply today: www.socmucimm.org/resources/gr...

#MucosalImmunology #Mentorship #ProfessionalDevelopment

DEADLINE EXTENDED to submit your abstract for ICMI 2026! *SMI members receive 100% off abstract submission fees (email info@socmucimm.org to get your discount code).

Submit here before February 27: bit.ly/4szJDfe
#ICMI2026 #MucosalImmunology

Mucins in health and disease 15-18 June 2026, Ghent, Belgium Supported by VIB Training & Conferences

Registration is open for Mucins in Health and Disease! 15–18 June 2026, Ghent - Belgium

All info on:
www.vibconferences.be/events/mucin...

Travel awards available from @societymucosalimm.bsky.social and @mucosalimmunol.bsky.social

#Mucins #MucosalImmunology #Microbiome #Inflammation

FINAL HOURS to submit your abstract for ICMI 2026!

*SMI members receive 100% off abstract submission fees (email info@socmucimm.org to get your discount code).

Submit here before January 31: bit.ly/4szJDfe

#ICMI2026 #MucosalImmunology

Siniscalco, Fisher, Lu, Eisenbarth, Gowthaman et al. reveal that DOCK8 and STAT3 cooperate in CD4⁺ T cells to restrain Tfh13 differentiation and prevent food-specific IgE. rupress.org/jem/article/...

#LymphocyteBiology #MucosalImmunology #HumanDiseaseGenetics

Explore new #Immunology papers incl. antitumor T cell responses, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, #myeloid cells ontogeny & the impacts of #circadian checkpoints on their function, and local B cell alterations in #neuroinflammation. 👉 rupress.org/jem/collecti...

Only 1 week left to submit your abstract for ICMI 2026!
*SMI members receive 100% off abstract submission fees (email info@socmucimm.org to get your discount code).
Submit here by next Friday, January 30:
bit.ly/4szJDfe

#ICMI2026
#MucosalImmunology

Explore the latest #Immunology research, incl. antitumor T cell responses, central & peripheral #tolerance establishment and maintenance, intestinal #MucosalImmunology, metabolic adaptation in Th2 responses, and more, to accompany @midwinter-immun.bsky.social conference 👉 rupress.org/jem/collecti...

It’s #MucosalMonday! New episode coming next week; in the meantime, check out episode 12, "Allergy from AIC, part 1."

Listen here -> bit.ly/4lxNC7F

#MucosalImmunology #Immunology

Only 2 weeks left to submit your abstract for ICMI 2026!

*SMI members receive 100% off abstract submission fees (email info@socmucimm.org to get your discount code)

Submit here by Friday, January 30: bit.ly/4szJDfe

#ICMI2026 #MucosalImmunology #CallForAbstracts #AcademicResearch #Immunology