🧬 RNA modification on demand: #Yeast pseudouridine synthase PUS7 switches from nuclear tRNA editing to cytoplasmic mRNA modification during stress; strategic relocalization helps cells survive reactive oxygen species & metal ion challenges
🔬 #YeastResearch 🧪 #SGD
www.yeastgenome.org/reference/S1...
🧠 Smart cellular response: When #Yeast lacks iron & fatty acids, piecemeal microautophagy targets mislocalized iron regulators for disposal. Shows stressed cells coordinate iron control with fat metabolism through selective protein removal
🧬 #YeastResearch 🧪 #SGD
www.yeastgenome.org/reference/S1...
🫧 Gaseous regulation: #Yeast uses gasotransmitter hydrogen sulfide to modify cysteine residues via S-persulfidation. This post-translational modification controls protein activity, localization, & protects against oxidative stress
🧬 #YeastResearch 🔬 #SGD 🧪
www.yeastgenome.org/reference/S1...
The new #Yeast issue of January-March 2026 (Volume 43, Number 1-2) is now out, with a review on the role of Rad9 in DNA repair, and three research articles spanning the isolation of yeast species from flowers and honeys, and the effects of furanic compounds.
onlinelibrary.wiley.com/doi/10.1002/...
⛑️ DNA damage triage: #Yeast cells use Slx4/Fun30 to dial down checkpoint signals specifically at damaged replication forks; local dampening allows controlled resection & proper repair at stalled forks
🧬 #YeastResearch 🔬 #SGD 🧪 #CellCycle
www.yeastgenome.org/reference/S1...
🧬 Autophagers, assemble! #Yeast study shows Golgi-derived lipid travels on Atg9 vesicles to organize pre-autophagosomal structures. Without this messenger, downstream #autophagy proteins can't assemble properly for cellular cleanup
🧪 #YeastResearch 🔬 #SGD
www.yeastgenome.org/reference/S1...
⏰ Only 2 DAYS left for early registration! Join us at #Yeast26 (June 13-17, Pacific Grove, CA) for cutting-edge research in #genetics, #genomics, #disease, #regulation, #systemsBiology, #cellBiology, #lifeCycle, #syntheticBiology, & more. Register by April 16 to save! 🧬 genetics-gsa.org/yeast-2026/
💻 Meet PYEAST: New computational toolkit modernizes #Yeast genetic engineering by encoding widely-used methods & integrating DNA synthesis advances ➡️ more accessible strain transformation without complex pipelines
🧬 #YeastResearch 🧪 #SGD 🔬 #ComputationalBiology
www.yeastgenome.org/reference/S1...
🏘️ Epigenetic neighborhoods: #Yeast genome has distinct regions where H3K79 methylation levels (me1/me2/me3) create different gene expression zones. Each zone has specific transcriptional functions: some activate, others repress genes
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🍻 Hidden brewing treasure: Traditional farmhouse ale cultures preserve remarkable #Yeast genetic diversity lost in industrial strains; study of 1,760 isolates reveals cultures may contain 30+ variants ➡️ unique flavors & stress tolerance
🧬 #YeastResearch 🧪 #SGD
www.yeastgenome.org/reference/S1...
🔬 Tiny modifications, big impacts: Loss of 2′-O-methylation in #Yeast ribosomes disrupts translation of ribosomal protein genes & reduces thermostability. Conserved RNA modification maintains ribosome structure & cellular stress responses
🧪 #YeastResearch 🧬 #SGD
www.yeastgenome.org/reference/S1...
🌊 Get ready for YGM2026- the ultimate #Yeast genetics experience! World-class science meets Pacific Grove paradise
June 13-17
🏨 Stay on-site: deadline April 8
⏰ Conference registration ends April 22
This is THE meeting you don't want to miss! We'll see you there!
#Yeast26 #Asilomar #YeastGenetics
🎶 Poetry (RNA) in motion: Single-molecule FRET reveals #Yeast tRNAs constantly sample open, compact & intermediate conformations. Pseudouridine synthase Pus4 binding creates new structural states & continues remodeling tRNA post-catalysis
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
Currently reserved yeast gene names: www.yeastgenome.org/search?q=&ca...
🧬 Characterized an unnamed #yeast #gene?
1. Name with 3 letters + number (ex. XYZ1) to reflect function.
2. Reserve your unique name at SGD while preparing manuscript www.yeastgenome.org/reserved_nam...
3. Include both ORF & gene names in your publication! 📝
Help: sites.google.com/view/yeastge...
🎮 Sphingolipid control center: #Yeast ceramide synthase assembles into regulated complexes that modulate ceramide output. Protein oligomerization serves as sophisticated regulatory mechanism during biosynthesis perturbations
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
👍 Fine-tuning DNA replication: #Yeast DNA polymerase ε thumb insertion balances processivity & proofreading. Small changes can either boost or reduce performance -> subtle regulation with major consequences for genome stability
🧬 #YeastResearch 🔬 #SGD 🧪
www.yeastgenome.org/reference/S1...
Reminder that you can get up-to-date curated data, including gene names, #GO annotations, #phenotypes, #PTMs, #disease, #interactions, biochemical #pathways, #regulation, #complexes, etc. from SGD Downloads. Updated weekly. Get your data and get to work: sgd-archive.yeastgenome.org/curation/lit...
📈 Resilient reproduction: 1st genome-wide localization of #Yeast Mms4p reveals preference for weak DNA break sites & chromosome axis regions, unlike Msh5 which favors strong sites; the two crossover pathways complement rather than compete
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🧬 Decoding heterosis: Large-scale analysis of #Yeast hybrids shows genetic distance drives stress tolerance gains. Most hybrids display mid-parent #HybridVigor, with strongest benefits in high ethanol and high salt
🔬 #YeastResearch 🧪 #SGD #Genetics
www.yeastgenome.org/reference/S1...
🍻🌏🍻 Beyond commercial strains: Native #Yeast species like S. cerevisiae, Brettanomyces & Torulaspora create unique flavors in #CraftBrewing. Review shows how local microorganisms enhance terroir expression while preserving biodiversity
🧬 #YeastResearch 🧪 #SGD
www.yeastgenome.org/reference/S1...
🔋 Cellular powerhouse assembly: Review details how #Yeast builds & maintains respiratory chain complexes through coordinated nuclear import + mitochondrial protein synthesis, providing key insights into energy machinery biogenesis
⚡️ #YeastResearch 🧪 #SGD 🧬
www.yeastgenome.org/reference/S1...
💞 Cellular matchmaking: #Yeast condensin loop extrusion brings together broken DNA and repair donors during mating-type switching. Study reveals how SMC complexes facilitate homology search by creating specific chromosomal loops
🔬 #YeastResearch 🧬 #SGD 🧪
www.yeastgenome.org/reference/S1...
🍺 Perfecting nonalcoholic beer: Study compares maltose-negative #Yeast strains with arrested fermentation approach using high-gravity brewing. Strategic yeast selection + glucose oxidase treatment= ⏫ flavor & ⏬ ethanol
🧬 #YeastResearch 🔬 #SGD 🧪
www.yeastgenome.org/reference/S1...
🔥 Heat-resistant breakthrough: Evolved #Yeast strain TT-M6 thrives at high temperatures, producing 74.8 g/L ethanol from lignocellulose at 37°C. A few key mutations enable efficient biofuel production from agricultural waste
🔬 #YeastResearch 🧬 #SGD 🧪 #Biofuels
www.yeastgenome.org/reference/S1...
🍾 Tiny bubbles make us happy: Picolitre microbead method screens millions of #Yeast mutants in 0.3 mL, cutting expensive antimetabolite costs. Label-free autofluorescence detection achieves 16,000-fold enrichment of resistant strains
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🐈🐕 Unexpected partnership: #Yeast mitochondrial import complex teams up with Ayr1p to create lipid droplet contact sites. The MIM complex handles protein insertion when alone, lipid metabolism when bound to Ayr1p
🧪 #YeastResearch 🧬 #SGD 🔬 #CellBiology
www.yeastgenome.org/reference/S1...
🔍 #Yeast as disease detective: Humanized seipin-deficient model examines how acetyl-CoA misrouting drives futile lipid cycles in #MotorNeuronDisease, highlighting #APOYG for understanding complex human metabolic disorders
🧬#YeastResearch 🧪#SGD 🔬#ModelOrganism
www.yeastgenome.org/reference/S1...
💪 Double duty: #Yeast phosphofructokinase β-subunit (Pfk2p) moonlights as RNA unwinder and translation activator for cell cycle genes- this energy enzyme controls cell proliferation independently of glycolysis.
🧬 #YeastResearch 🔬 #SGD 🧪 #CellCycle
www.yeastgenome.org/reference/S1...