🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling.
Explore RAS at the complex level → new therapeutic insights.
#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
🧬 Oncogenic KRAS mutations (pancreatic, colorectal, lung cancers) stabilize these complexes, sustaining growth signalling.
Explore RAS at the complex level → new therapeutic insights.
#RAS #KRAS #RASopathies #CancerBiology #ComplexPortal
Now curated:
• SHOC2-MRAS-PP1 phosphatase complexes (RAF activation; linked to RASopathies incl. Noonan-like syndromes)
• KRAS/HRAS-SOS1 activation complexes
• KRAS-RAF1 & KRAS/MRAS-PIK3CA effector complexes
🔬 𝑵𝒆𝒘! 𝐑𝐀𝐒 𝐬𝐢𝐠𝐧𝐚𝐥𝐥𝐢𝐧𝐠 𝐜𝐨𝐦𝐩𝐥𝐞𝐱𝐞𝐬 𝐢𝐧 𝐭𝐡𝐞 𝐂𝐨𝐦𝐩𝐥𝐞𝐱 𝐏𝐨𝐫𝐭𝐚𝐥
RAS proteins function in multi-protein assemblies that drive MAPK & PI3K signalling.
Integrating of disease reference resources like MONDO, OMIM & EFO into the Complex Portal helps map diseases to complexes a powerful lens for research and clinical insight.
#RareDiseaseDay #Genetics #MolecularComplexes #CMT #SAVI
🔬 Dynein complex variants (e.g. DYNC1H1) impair axonal transport → Charcot-Marie-Tooth disease (CMT).
🔥 STING gain-of-function variants hyperactivate interferon signalling → SAVI.
💜 Individually rare, collectively affecting millions. Linking variants → protein complexes → phenotypes is key for diagnosis and therapy. Visit the Complex Portal to explore complexes such as the Dynein & STING complexes. tinyurl.com/3whub3ey
🌍 Rare Disease Day: When Molecular Complexes Break
Rare diseases aren’t just “gene disorders” - many disrupt macromolecular complexes, the molecular machines that keep cells running.
Bridging experimental curation & structural prediction to expand insight into complex composition and architecture.
#ComplexPortal #ProteinComplexes #StructuralBiology #huMAP30 #MuSIC #QSProteome
🔎 Exploring predicted complexes in the Complex Portal
Beyond curated entries, the portal also includes computationally predicted protein complexes.
Quick tour: tinyurl.com/2wph5wua
Includes:
🧬 hu.MAP 3.0
🎵 MuSIC
🧪 QSProteome
🌉By integrating QSProteome, the Complex Portal bridges experiment-based curation & computational prediction, empowering exploration of alternative structural data.
📖Edward Catoiu et al.,PMID: 41163446 👉 tinyurl.com/4578uktz
#ComplexPortal #QSProteome #ProteinComplexes #StructuralBiology #PalssonLab
🔗 References are available for 4,000 manually curated and 12,960 predicted complexes, with
🧊 interactive 3D models,
📊 quality metrics (pLDDT, ipTM, PAE),
🧾 functional annotations, and 🛠️ community curation.
🎉 Update from the Complex Portal!
🧬 The Complex Portal now links to QSProteome, a community-driven resource for predicted protein complex structures.
👏 Thanks to our collaborators and the Complex Portal community!
🔗 Explore: www.ebi.ac.uk/complexporta...
#ComplexPortal #ProteinComplexes #IntAct #UniProt #OpenScience #FAIRdata #EMBL_EBI 🎊
🎉 Complex Portal release 252 is out! 🎉
5,296 manually curated biological complexes are now live, in sync with UniProt 2026_01 🚀
Highlights by species:
🧬 Homo sapiens – 2,499
🌱 Arabidopsis thaliana – 228
🧫 Saccharomyces cerevisiae – 634
🧬 Schizosaccharomyces pombe – 145
Complex Portal release 252 is out! 5,296 manually curated biological complexes. www.ebi.ac.uk/complexporta... (in sync with UniProt release 2026_01)
Are you working on challenging projects in structural biology?
#EMBOMacromolecular will highlight the strategic use of cutting-edge protein structure prediction methods, and recent advances in in situ structural biology. Apply by 18 Feb to join us at EMBL Grenoble! 🧬
s.embl.org/mmo26-01-bl
👩🔬 𝐒𝐨 𝐭𝐡𝐢𝐬 𝐍𝐞𝐰 𝐘𝐞𝐚𝐫, let’s resolve not just to feel healthier, but to understand how our biology really works - guided by evidence, tools, and data that are openly accessible and citable. 🧠✨
#COMPLEXPORTAL #IntAct #UniProt #EMBLEBI #NEWYEAR2026
Explore key blood & circulation complexes:
1. 🩸 Haemoglobin
🔗 tinyurl.com/3rdhwk3h
2. 🧴 Cholesterol homeostasis
🔗 tinyurl.com/23hvtnzx
3. 🧪 Prothrombinase (coagulation)
🔗 tinyurl.com/34m7f5e7
4. 🛡 Complement C3/C5 convertases
🔗 tinyurl.com/mujtd345
At the Complex Portal, we curate assemblies from haemoglobin complexes (CPX-2158, CPX-2159, CPX-2160) that carry oxygen, to complexes regulating coagulation (CPX-6221), cholesterol homeostasis (CPX-632), and immune clearance - all essential for healthy circulation.
🧬 New Year, new health goals - let’s get real: exercise fads, diets & oxygen therapies promise “blood cleansing,” but oxygen transport, circulation, cholesterol, and immune defence rely on real macromolecular complexes, not detox trends.
🌿 Why it matters
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species
💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
🌱 Balancing Act: Plants & Ammonium
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
🌿 Why it matters
• Excess NH₄⁺ disrupts growth and cellular balance
• Species differ in ammonium tolerance, influencing biodiversity
• Human-driven nitrogen favours ammonium-tolerant species
💡 Plants aren’t passive nitrogen absorbers-they actively regulate uptake to balance nutrition and stress.
This protects plants from ammonium toxicity and shapes species fitness across different nitrogen environments.
Learn more via the Complex Portal: tinyurl.com/yn9zzfav
🌱 Balancing Act: Plants & Ammonium
Plants constantly adjust to shifting nitrogen levels. Ammonium transporters (AMTs) mediate NH₄⁺ uptake, redistribution, & sensing.
💡At high ammonium, AMT complexes rapidly shut down uptake via phosphorylation & later reduce AMT gene expression.
Registration is free but essential: tinyurl.com/4v3jf4e9
Speakers: Susie H. and Eliot Ragueneau
#Bioinformatics #IntAct #Modelling #BiologicalNetworks #Cytoscape
Would you like to learn more about molecular interactions and how to explore them across organisms?
Join us next week for an introductory webinar where we will walk through the IntAct Portal's approach to molecular network modelling and show how this is implemented within the IntAct Cytoscape app.
