A one minute primer on how #AutoSpectral improves spectral flow cytometry unmixing by using per-cell calculation of autofluroscence spectra.
Use our R package and get higher quality spectral data, easy as that!
www.biorxiv.org/content/10.1...
Resident tissue #macrophages (RTM) are now recognized as integral regulators of tissue physiology, not transient immune sentinels. one fundamental question remains unresolved: why do some populations achieve lifelong self-maintenance, while others are replaced under steady-state conditions? 🧵1/11
Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1
Sonia Garel, @morganethion.bsky.social and collaborators
www.embopress.org/doi/full/10....
Not only my photos are being stolen now, people are selling them under someone else's name😡😡. I intentionally never sold my images for profit. Check the photos below. Mine is in the left, the stolen one in the right. Does someone knows how to sue them?
www.cell-and-art.com/en/product/a...
🔬 Research Spotlight
#Microglia-derived extracellular vesicles promote OPC differentiation by rewiring mitochondrial metabolism — revealing new therapeutic targets for demyelinating & neurodegenerative diseases.
👉 link.springer.com/article/10.1007/s10571-0...
Pre-print alert! And this one really is a must read for anyone that does spectral #flowcytometry. It is a complete, fully-automated spectral unmixing pipeline that reduces error up to 9000-fold.
Want to get a tough sample, like lung, looking like this? Read more!
www.biorxiv.org/content/10.1...
A world-first 🌈🧬 Published today in Nature Medicine: gender-affirming hormone therapy changes the body’s proteins, aligning biology with gender identity.
Led by @unimelb, @MCRI_for_kids & @Austin_Health — a huge step for #TransHealth research.
🔗 www.nature.com/articles/s41...
Thank you soooo much for this. Kudos to the whole team behind this project. 👏👏
Few days late,but huge thanks to my home institute, TuDMM-UTU, for the finishing grant 😇✨
Figure 4 - CSF1 and IL34 protein increase throughout development and display distinct spatiotemporal transcriptional expression patterns; panel L. Density maps depicting the spatiotemporal expression patterns of Il34 (top) and Csf1 (bottom) transcripts in RNAscope™ across development. Left to right: P3, P10, P30. Warmer colours indicate greater while cooler colours indicate lower transcript density.
CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation
Read this #LifelongDevSI Research Article by Brady P. Hammond, Jason Plemel @jrplemel.bsky.social and colleagues:
journals.biologists.com/dev/article/...
Just presented my work. Now I’m off to my cave to finish writing. Yup, PhD is just a few BIG steps closer. Until then, I’ll keep chugging my matcha to keep me awake, and buying plants to distract me from failed experiments. 😆
Huge thanks to people who support me everyday: to my real friends in this field who always move with pure intentions, to my friends outside the lab, to my second mother, and most especially, to my loving husband and his family who always believe in me. (3/n)
It’s always my pleasure to share the science I do, and I am beyond grateful for these opportunities. It’s very humbling. The world is full of envy and people who are unhappy to see our successes, but we strive to move forward and to redirect ourselves to better places. (2/n)
In 2018, I presented my Bachelors thesis at the biggest Microbiology conference in the Philippines and won the best presentation award. In 2021, I also got a presentation award for my Masters thesis in Taiwan. Last week, I presented my PhD work to the European Macrophage and DC Society in UK. (1/n)
If NIH shuts down funding of animal-only grants, get ready for a whole lot of grants to include some pointless organoid experiments just to qualify. What a terrible rule!
www.drugdiscoverytrends.com/nih-announce...
Honeymoon series
📍Italia
Our first month of marriage and first midsommar as husband and wife in Åland Islands ♥️☀️
📘 Our #Neuroimmunology & #Neurodegeneration collection covers a broad range of topics including macular degeneration, the role of #microglia, β-amyloid transport, CNS #autoimmunity, and the sympathetic control of cancer progression 👉 rupress.org/jem/collecti...
@keystonesymposia.bsky.social
On-demand microglia deliver the therapeutic payload in Alzheimer’s disease @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...
I got married!
Crazy microglia!
Me outside the summer cottage, the day after the wedding
Spine or kidney? Haha
My month so far. In science, or in life… I love everything that’s been happening! ♥️🥰
Final push in the lab before I prepare for my wedding 🫣🥰🥹👰♀️
Join us for the Spatial Biology Seminar by Lunaphore Technologies and Bio-Techne!
📅 Date: May 28
🕝 Time: 14:30-16
📍 Location: Seminar room BEAR, Biocity B, 5th floor
We’ll kick things off with coffee&pulla, followed by presentations on spatial biology solutions from Ronald Pouyo and colleagues.
Amyloid-β induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimer’s disease: @cp-immunity.bsky.social www.cell.com/immunity/ful...
A study in Science immunology shows the type of dead cell ingested by macrophages governs their functional plasticity. YOU ARE WHAT YOU EAT
www.science.org/doi/10.1126/...
I’m getting married 🥹
It just feels surreal that after crossing the horizons to search for greener pastures, I ended up in the happiest place on Earth and found the love of my life: my strength in times of darkness, my biggest supporter when I felt like losing some grip. I’m lucky.
MSc Karolina Losenkova Mingeaud's dissertation examines the broad network of enzymes involved in ATP and adenosine metabolism, improving the understanding of adenosine metabolism within the tumor microenvironment.
🎩 Losenkova Mingeaud defends the dissertation on 7 March.
www.utu.fi/en/news/even...
Nasal anti-CD3 monoclonal antibody ameliorates traumatic brain injury, enhances microglial phagocytosis and reduces neuroinflammation via IL-10-dependent Treg–microglia crosstalk
www.nature.com/articles/s41...
Hi! I’m Ae. I like studying macrophages & microglia. I like being alone in the dark microscope room, playing with flow cytometers, & challenging myself with bioinformatics. I also have many passion outside the lab: I love to cook, take care of plants, sing, & see new places! Nice to meet you here! 🥰
PAMs, DAMs, and WAMs: tracking microglia across the development and disease landscape
www.biorxiv.org/content/10.1...
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...
