Excited to advertise a fully funded PhD with @socialinfluenza.bsky.social investigating how influenza virus evolution differs between different avian hosts (and how this impacts pandemic potential). Joint between @pirbrightinst.bsky.social + @cvrinfo.bsky.social
www.findaphd.com/phds/project...
Posts by Chlanda lab
Congratulations to Dao Thi lab @daothilab.bsky.social
and collaborators! Beautiful work! @ciid-heidelberg.bsky.social
Meet our new #AllianceFellow Jack Whitehead!
The short interview about his work in the @chlandalab.bsky.social and Mahamid lab at @embl.org can be found on our LinkedIn account.
@jackwh18.bsky.social
We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !
Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.
www.biorxiv.org/content/10.6...
Structural basis of caveolin-driven membrane bending
Afterwards a panel discussion was moderated by Caroline Schlaufer featuring film director Christian Frei, biosafety expert Kathrin Summermatter & virologist @profvolkerthiel.bsky.social. The audience posed great questions on funding, biosafety & media polarisation.
📢Job alert📢
@uniheidelberg.bsky.social has an opening for a full W3-position on “Modeling of Biological Processes” 😀👍 Here is the call
tinyurl.com/3w9e9dtf
and application deadline is March 15. The group would be located at the beautiful #BioQuant center right in the middle of Neuenheimer Feld.
Trapozoid cryo-FIB milling allows to prepare a lamella for dual-axis cryo-ET and assessment of different deep-learning missing-wedge restoration algorithms. rdcu.be/e2nXE
New Article! Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET
Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)
🔗 biorxiv.org/content/10.6...
Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...
Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info.
Deadline 8 Feb. Apply here:
umustipendie.varbi.com/en/what:job/...
#virus #virology #teamtomo #cryoEM
Sharing this here at the request of Dr. Florian Krammer:
semmelweisinstitute.ac.at/training-car...
Spillover of #influenza A viruses from animals to humans represents a threat to our health. In this Perspective, Silke Stertz @virology.uzh.ch discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II receptors across species 🧪 #virology plos.io/4pP3Gnq
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
Our new preprint is out 🥳🥳🥳
Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?
👇
Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.
For more details and to apply please see
www.imperial.ac.uk/jobs/search-...
warwick.ac.uk/fac/cross_fa...
I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.
If you're interested reach out and I'd be happy to have a chat.
Thank you, Lars, for the invitation and for the opportunity to share the work. It was a great meeting and also a very nice opportunity to go again to beautiful Umeå!
Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.
“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...
Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...
Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026
Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them:
www.sciencedirect.com/science/arti...
Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging
Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social
www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social
One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...
Awesome malaria study out now in Nature Microbiology:
An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission
By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!
@freddyfrischknecht.bsky.social
www.nature.com/articles/s41...