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Posts by Chlanda lab

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FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow on FindAPhD.com PhD Project - FULLY FUNDED PhD - Visualising avian influenza virus tropism and co-infection in avian hosts at University of Glasgow, listed on FindAPhD.com

Excited to advertise a fully funded PhD with @socialinfluenza.bsky.social investigating how influenza virus evolution differs between different avian hosts (and how this impacts pandemic potential). Joint between @pirbrightinst.bsky.social + @cvrinfo.bsky.social

www.findaphd.com/phds/project...

1 week ago 30 30 1 0

Congratulations to Dao Thi lab @daothilab.bsky.social
and collaborators! Beautiful work! @ciid-heidelberg.bsky.social

1 week ago 2 1 0 0
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Meet our new Alliance Fellow Jack Whitehead! Q: Could you tell us a bit about the work you do? Which field do you work in and who are your PIs? A: I am a structural biologist, and my work looks at… |... Meet our new Alliance Fellow Jack Whitehead! Q: Could you tell us a bit about the work you do? Which field do you work in and who are your PIs? A: I am a structural biologist, and my work looks at th...

Meet our new #AllianceFellow Jack Whitehead!
The short interview about his work in the @chlandalab.bsky.social and Mahamid lab at @embl.org can be found on our LinkedIn account.
@jackwh18.bsky.social

1 week ago 9 5 0 0
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Deltaviruses spread through a viral Trojan Horse Hepatitis D-like satellite viruses, known as deltaviruses, have been recently discovered in a wide range of animals. These viruses are thought to expr…

We found a viral Trojan Horse: a virus can hide inside another virus.This one surprised us: deltaviruses don’t just borrow a helper virus. They can travel inside it.
A literal Trojan Horse “virus-in-a-virus” route into cells. 🤯 Kudos to 1st author @viroscope.bsky.social and co-authors !

1 month ago 200 98 8 15
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Our latest preprint is now available doi.org/10.1101/2025...! Led by my postdoc, Luqiang Guo @luqiang.bsky.social, we determined a ~2.4 A resolution structure of the hantavirus glycoprotein tetramer on the surface of VLPs. Also determined structures of dimers of tetramers and Fab-bound tetramers.

10 months ago 79 26 2 2

www.biorxiv.org/content/10.6...

Structural basis of caveolin-driven membrane bending

2 months ago 2 2 0 0
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Afterwards a panel discussion was moderated by Caroline Schlaufer featuring film director Christian Frei, biosafety expert Kathrin Summermatter & virologist @profvolkerthiel.bsky.social. The audience posed great questions on funding, biosafety & media polarisation.

2 months ago 4 3 1 0
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📢Job alert📢

@uniheidelberg.bsky.social has an opening for a full W3-position on “Modeling of Biological Processes” 😀👍 Here is the call

tinyurl.com/3w9e9dtf

and application deadline is March 15. The group would be located at the beautiful #BioQuant center right in the middle of Neuenheimer Feld.

2 months ago 32 28 0 1
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Trapozoid cryo-FIB milling allows to prepare a lamella for dual-axis cryo-ET and assessment of different deep-learning missing-wedge restoration algorithms. rdcu.be/e2nXE

2 months ago 17 4 0 0
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Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET Nature Protocols, Published online: 30 January 2026; doi:10.1038/s41596-025-01284-zA protocol for cryogenic 3D correlative focused ion beam milling using an integrated fluorescence light microscope and montage cryo-ET for nonadherent and adherent mammalian cells, as well as primary Drosophila melanogaster neurons.

New Article! Integrated fluorescence light microscopy-guided cryo-focused ion beam-milling for in situ montage cryo-ET

2 months ago 37 14 0 2
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Check out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3)

🔗 biorxiv.org/content/10.6...

2 months ago 72 18 2 1
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Cryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...

2 months ago 54 27 1 0
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Cryo-electron tomography reveals coupled flavivirus replication, budding and maturation - Nature Communications In this study, Dahmane et al use a method called cryo-electron tomography to uncover new details of how tick-borne flaviviruses transform cells into virus factories.

I am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look!
#virology #teamtomo
www.nature.com/articles/s41...

2 months ago 105 31 1 2
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Open #postdoc fellowship in my group. Virus replication and cryo-ET. Projects can be tailored to ambitious candidates with diverse backgrounds, so don't hold back from applying! DM for more info.

Deadline 8 Feb. Apply here:
umustipendie.varbi.com/en/what:job/...
#virus #virology #teamtomo #cryoEM

3 months ago 34 28 2 3
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Sharing this here at the request of Dr. Florian Krammer:

semmelweisinstitute.ac.at/training-car...

4 months ago 10 9 0 0
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A new path to spillover: MHC-II entry of influenza A viruses Spillover of influenza A viruses from animals to humans represents a threat to our health. This Perspective discusses emerging research that suggests some influenza A viruses can enter host cells via…

Spillover of #influenza A viruses from animals to humans represents a threat to our health. In this Perspective, Silke Stertz @virology.uzh.ch discusses emerging research that suggests some influenza A viruses can enter host cells via MHC-II receptors across species 🧪 #virology plos.io/4pP3Gnq

4 months ago 28 16 0 0
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Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

5 months ago 36 39 2 1
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Our new preprint is out 🥳🥳🥳

Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence?

👇

5 months ago 111 47 3 2
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Please RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

5 months ago 49 40 1 0
Dr Jeremy Keown Dr Jeremy Keown

warwick.ac.uk/fac/cross_fa...

I am advertising for a PhD position in my group. We'll be investigating how pathogenic RNA viruses replicate in the nucleus. The project will teach cryoEM/ET, virus culture, and in vitro assays.

If you're interested reach out and I'd be happy to have a chat.

5 months ago 15 18 0 1

Thank you, Lars, for the invitation and for the opportunity to share the work. It was a great meeting and also a very nice opportunity to go again to beautiful Umeå!

5 months ago 2 0 0 0
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Mysteries of trafficking of the vRNP segmented genome and assembly of influenza A virus revealed by in situ cryo-ET!
🔗 rdcu.be/eMmct
We are very excited that our paper is finally out!
🎉 Big congratulations to Moritz Wachsmuth-Melm and to everyone involved.

5 months ago 74 28 1 3
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“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optogenet...

“Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science www.science.org/doi/10.1126/...

6 months ago 9 5 0 0
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Check out our new preprint on an integrated pipeline combining in situ #cryo-ET with MALDI #MSImaging for single-cell identification and classification from previously analysed EM-grids.
Link: www.biorxiv.org/content/10.1...

7 months ago 54 14 1 2
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Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit
www.nexperion.net/semcm2026

6 months ago 51 22 0 1
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Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM Viral proteins typically exist in the context of complex virions or in the even more complex host cells in which they replicate. Hence, meaningful ins…

Since it was published at peak holiday season, I'm taking the liberty to re-introduce our recent review article. We hope it will be a useful overview of RNA virus replication strategies, and how in situ cryo-EM have helped us understand them:
www.sciencedirect.com/science/arti...

6 months ago 11 6 0 1
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Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

7 months ago 142 62 3 4
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PhD student in cryo-ET of membrane trafficking at MPI-NAT in Göttingen, DE Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

One week left to apply for a fully funded PhD position in my group! Please repost. jobrxiv.org/job/max-plan...

8 months ago 11 4 0 0
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An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission - Nature Microbiology A unique Arp2/3 complex in malaria parasites enables DNA segregation during the rapid formation of male gametes by safeguarding the attachment of chromosomes to the mitotic spindle.

Awesome malaria study out now in Nature Microbiology:

An atypical Arp2/3 complex is required for Plasmodium DNA segregation and malaria transmission

By Franziska Hentzschel, Matthias Marti, Freddy Frischknecht & colleagues!

@freddyfrischknecht.bsky.social

www.nature.com/articles/s41...

10 months ago 28 10 0 0
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Influenza filaments: a graveyard of postdocs no longer? | The EMBO Journal EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Really enjoyed writing about one of my favorite topics (influenza filaments). There is so much exciting new filament research now, it is clearly no longer 'the graveyard of postdocs' Bob Lamb called the topic during my PhD. www.embopress.org/doi/full/10....

10 months ago 19 8 0 0