New funding for Korean-German collaboration! 🇰🇷 🤝🇩🇪

Backed by the @dfg.de, the Albert group @mareikealbert.bsky.social @tudresden.bsky.social partners with Korean researchers to study how epigenetics and the extracellular matrix shape the human cortex 🧠 🧬

Read more ➡️ tud.link/qqvtcv

#CMCBnews

Congratulations, Dr. Marchenko 🥳
We got to enjoy a fantastic presentation! Looking forward to reading the manuscript.

Exciting news 🧬 Funded by a Rise Up! grant from @boehringerglobal.bsky.social, the Albert group @mareikealbert.bsky.social will explore how epigenetics shapes the timing of brain development across species.

Read more ➡️ tud.link/uakytp

📣 Deadline extension for #EMBOBrainEpi!

Good news for anyone who did not submit an abstract for the EMBO Workshop 'Brain (epi)genome': the abstract deadline is now 26 January 👉 s.embl.org/brg26-01-bl

Join us to explore how genome and epigenome shape brain cell diversity, function, and disease 🧠

🥂 We have a new PhD!!! Congratulations to Theresa Schütze for an excellent PhD defence! 🥳 The result of hard work, dedication and curiosity. Very well deserved! Thank you to the committee members. Stay tuned for the manuscript!!! 🧠 🧫 🦍 🧬

@crtd-tud.bsky.social #DIGS-ILS #CNV alumnus

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

Proud to see your story featured on the cover of #Neuron! 🤩

Along with a great #preview from Fides Zenk lab @epign.bsky.social

www.cell.com/neuron/abstr...

Thank you for highlighting our work and putting into perspective! ☺️

Unlocking the epigenome: Single-cell histone profiling in cortical development Ditzer et al. used single-cell cytometry by time-of-flight-based method for epigenetic analysis to profile histone modifications in the primary human …

Excited to share our News & Views in Neuron, co-authored with Yong-Qi Gao 🎉🧠

👉 www.sciencedirect.com/science/arti...

It highlights the fantastic new work from the @mareikealbert.bsky.social lab.

Huge congrats 🥳 So well deserved!

🥳 Congratulations to our postdoc, Dr. Anna Czarkwiani @aniaczark.bsky.social, on receiving the ERC Starting Grant @erc.europa.eu!

With €2 million in funding, Anna will explore the biology of gravisensation and uncover insights into related disorders. 🧠

#CMCBnews @tudresden.bsky.social #ERCStG

GSCN 2025 Young Investigator Award goes to @bulutkarslioglu.bsky.social of the Max Planck Institute of Molecular Genetics in Berlin.
Find PR here www.gscn.org/ #stemcells #stammzellen #epigenetics #genetics @maxplanck.de @mdc-berlin.bsky.social @www.helmholtz-munich.de @bihatcharite.bsky.social

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.

Workshop Single Cell Genomics on 13 & 14 Oct in @www.helmholtz-munich.de , right before the @gscnoffice.bsky.social 13th Conference. Register and be part!
#stemcells #singlecell #genomics #data #stammzellen #organoids

Brain Surfaces of 70 primate species

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To predict the behaviour of a primate, would you rather base your guess on a closely related species or one with a similar brain shape? We looked at brains & behaviours of 70 species, you’ll be surprised!

🧵Thread on our new preprint with @r3rt0.bsky.social , doi.org/10.1101/2025...

📣 Proud of this fantastic work by two amazing PhD students Nora Ditzer and Ezgi Senoglu from @crtd-tud.bsky.social. 🥳 👏 Huge thanks to all co-authors! Enjoy the read. (11/11)

Overall, this study comprehensively characterizes the epigenetic state of specific neural cell types and highlights a novel role for H3K27me3 in regulating the ECM composition in the human developing neocortex. (10/11)

Intriguingly, pharmacological PRC2 inhibition in human cortical organoids induces increased production of the ECM components Syndecan 1 and Laminin alpha 1. (9/11)

Our findings are especially interesting considering previous results from the Hippenmeyer lab, where PRC2 knockout in individual cells of the mouse cortex suggested a non-cell autonomous mechanism for the regulation of NPC fate decisions by PRC2. (8/11)

www.science.org/doi/epdf/10....

Our cell type-specific profiling of the genome-wide H3K27me3 profile not only identified neuronal differentiation, but also extra-cellular matrix (ECM) genes as targets of PRC2. (7/11)

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems - Nature Neuroscience The mechanisms underlying human cell diversity are unclear. Here the authors provide a single-cell epigenome map of human neural organoid development and dissect how epigenetic changes control cell fa...

Whereas a recent study from the Treutlein lab and @epign.bsky.social revealed a role of PRC2 in regulating the exit from pluripotency, we now dissect the role of PRC2 within the neural lineage after the initial cell fate commitment. (6/11)

www.nature.com/articles/s41...

We found that loss of H3K27me3 in human cortical organoids induces a shift of neural progenitor cell proliferation towards differentiation that results in reduced organoid size. (5/11)

Here, we performed pharmacological inhibition of PRC2 in human cortical organoids from week 3 to 8, leading to a near complete loss of H3K27me3, and studied NPC behaviour. (4/11)

An epigenetic barrier sets the timing of human neuronal maturation - Nature The slow maturation of human neurons is regulated by epigenetic modification in nascent neurons, mediated by EZH2, EHMT1, EHMT2 and DOT1L.

These results beautifully align with a recent study from the Studer lab where PRC2 was shown to contribute to an epigenetic barrier that mediates the protracted maturation of human neurons compared to other species. (3/11)

www.nature.com/articles/s41...

We apply an innovative, highly multiplexed approach, Epi-CyTOF, to study > 30 epigenetic modifications at single-cell level in the human developing neocortex. We identify H3K27me3, deposited by PRC2, as the modification with the strongest cell type-specific enrichment. (2/11)

How do epigenetic modifications contribute to human #neocortex #development? Excited to see our work out in #Neuron. We applied Epi-CyTOF and identified a novel role for PRC2 in regulating #ECM.

@crtd-tud.bsky.social @cp-neuron.bsky.social

www.sciencedirect.com/science/arti...

A thread below 👇

How important is #epigenetics for human brain?

Researchers led by @mareikealbert.bsky.social used brain organoids 🧠 🧫 and Epi-CyTOF to show that histone methylation controls how brain cells multiply and how big the organoid grows.

Read more ➡️ tud.link/4ywe3g

#neuroscience #CMCBnews

Bilderstrecke aus 6 Fotos: Gruppenaufnahme der Teilnehmer*innen am See in Potsdam und weitere Personen-Abbildungen in kommunikativen Situationen

Rund 150 (!) aktuell und ehemalig Geförderte waren beim diesjährigen #EmmyNoether-Jahrestreffen - und es war wieder einmal lustig, produktiv, sonnig, kollaborativ, synergetisch, kommunikativ und noch viel mehr. 😊
Kurzer Bericht, mehr Impressionen & die Präsentationen zu den Talks:
fcld.ly/ent2025

Join us!!!!!

THE Symposium for all Chromatin and Epigenetics experts and 'lovers' this year!!!

Pls spread the word! We have a postdoc position available in the Rocha Lab @mpi-muenster.bsky.social. Join our team to study mechanisms underlying robust organ development using zebrafish embryos and human organoids.

mpi-muenster.mpg.de/career