We’ve been sciencing! M abscessus makes a arabinanase toxin to chop up the cell wall of competitor mycobacteria! #glycotime 🦠 thanks to @wellcometrust.bsky.social for the funding that makes this collaborative work possible! Also Sam’s structures are 😍 and Jean-Lou did some lovely biochem

Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University on FindAPhD.com PhD Project - Characterising antibacterial toxins in the food-borne pathogen Listeria monocytogenes at Newcastle University, listed on FindAPhD.com

www.findaphd.com/phds/project... interested in bacterial antagonism? PhD opportunity in our team, see below. Please repost!

BBSSRC (NEEDL) funded PhD studentship in my lab co-supervised by
@thecopperdoctor.bsky.social and @mycobacterium-ncl.bsky.social
If you're interested in structural biology and membrane transport processes, check out www.findaphd.com/phds/project... deadline 27th of Feb!
Get in touch for more info

Synthetic Biology for Light-Activated Smart Materials. at Newcastle University on FindAPhD.com PhD Project - Synthetic Biology for Light-Activated Smart Materials. at Newcastle University, listed on FindAPhD.com

Exciting CASE funded PhD opportunity available in the NEEDL PhD programme with me and Thomas Howard: eur03.safelinks.protection.outlook.com?url=https%3A...

We are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT

🚨Last chance to apply for two PhD projects in my lab, applying structural biology and single molecule biophysics to investigate gene expression in RNA viruses: www.findaphd.com/phds/?Keywor...

AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination - Nature Methods An analysis of AlphaFold protein structure predictions shows that while in many cases the predictions are highly accurate, there are also many instances where the predicted structures or parts of pred...

www.nature.com/articles/s41...

Please RT. Post-doc opportunity alert! 💥 closing soon 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems.

For more details and to apply please see

www.imperial.ac.uk/jobs/search-...

Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...

Proud and excited to see my first, first-author paper out on @pnas.org! Huge thank you to Jon @jmarlesw.bsky.social, Luning and my colleagues for their amazing guidance throughout.

www.pnas.org/doi/10.1073/...

Amazing. Congratulations.

Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...

Assembly, architecture and functional roles of microbial surface layers

Review article published in @natrevmicro.nature.com with @bupbuse.bsky.social, Andriko von Kügelgen and @vikramalva.bsky.social.

S-layers are everywhere!

www.nature.com/articles/s41...

Thanks Paula.

Thanks John. Also for the working link!

An illustration of a carbonic anhydrase complex in a synthetic mini-carboxysome

Pleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....

Structural insights into cobalamin loading and reactivation of human methionine synthase Human methionine synthase (MTR) is an essential enzyme of one carbon metabolism. Consisting of a catalytic N-half and a cobalamin binding C-half, MTR utilises this intricate organometallic cofactor in...

I am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...

Afternoon starts with former #Salgadolab student @adamcrawshaw.bsky.social getting the audience engaged on #microcrystals and @diamondlightsource.bsky.social VMXm beamline.

Another exciting day in Newcastle for structural biology! The CCP4 Structural Biology Meeting 2025 is here!

A great overview of #cryoEM in Newcastle from @jmarlesw.bsky.social at #NorthernEye opening @nusbf.bsky.social

Woo. The big day is finally here. @jmarlesw.bsky.social kicking off the Northern Eye Opening Symposium

Looking forward to catching up tomorrow.

Please join us in the North East on the 5th of November as we celebrate with a one day symposium for the launch of our BBSRC funded 100 keV Tundra TEM aka the Northern Eye:
nusbf.ncl.ac.uk/ccpem-tfs-ne...
The symposium has been kindly sponsored by
@thermofishersci.bsky.social & @ccpem.bsky.social

Characterisation and engineering of thermostable PLP-dependent alpha-oxoamine synthases (AOSs); versatile C-C bond forming biocatalysts The toolbox of C-C bond forming biocatalysts is forever expanding as demand increases for new and sustainable routes to organic molecules. One class o…

Interested in alpha-oxoamine synthases and their use in biotech? Here's a nice methods paper on the production and characterisation of an engineered T. maritima variant from colleagues in the @campopianogroup.bsky.social: www.sciencedirect.com/science/arti...

The Quinn group are interested in stress-sensing and signalling mechanisms in human pathogenic fungi and their importance in virulence. They are also interested anti-fungal mechanisms mediated by the bacterial type-vi secretion system.
👉 @nclfungalgroup.bsky.social
www.ncl.ac.uk/medical-scie...

The Palmer group are interested in the mechanisms bacteria use to compete with one another during colonisation. Her group are focused on the type vii secretion system and the toxins it exports.
Follow @proftracypalmer.bsky.social for more insights.
www.ncl.ac.uk/medical-scie...

Next up, @nickj-dent-res.bsky.social
His group is interested in all aspects of oral biofilms and how they contribute to oral health and disease. They look at adhesion and colonisation of surfaces, intermicrobial interactions and the role of the biofilm matrix.

blogs.ncl.ac.uk/nickjakubovi...

Next introducing Dr Alessandra Dantas.

The Dantas group is interested in stress responses, antifungal resistance and in understanding the molecular mechanisms driving fungal adaptation to environmental stressors.

@alesdantas.bsky.social

www.ncl.ac.uk/dental/about...

Last introduction for the today..

Dr Kesha Josts @kjosts.bsky.social

The Josts lab are working on the mechanisms of iron transport in bacterial pathogens, with a focus on Pseudomonas aeruginosa.

www.ncl.ac.uk/cbcb/staff/p...

@jmarlesw.bsky.social is a structural biochemist. His group are interested in how bacteria sense and respond to their environment. Jon is Academic Lead for our Electron Microscopy Facility and is excited for our new Tundra microscope to be up and running.

www.marles-wright-lab.org

Welcome week at the university again. Number 28 for me. Looking forward to welcoming our 7th MRes Biotech and Biodesign cohort this morning.