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Posts by Melissa E. Murray

Multiplex immunofluorescence of Aβ species

Multiplex immunofluorescence of Aβ species

🚨New in Lancet Neurology: Autopsy study of aducanumab in #Alzheimer’s shows superficial cortical Aβ cleared, but deeper persists. ARIA showed inflammation+ microinfarcts in leptomeningeal/penetrating vessels. Some path is PET-invisible. @drneurochic.bsky.social
authors.elsevier.com/a/1lxn85FFzL...

6 months ago 14 4 0 0
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Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration Murray et al. introduce “transformative neuropathology” through dynamic, technology-integrated approaches to accelerate tissue-based discoveries and offer actionable strategies to strengthen brain ban...

Why some people have more fit brain cells at 90 when others’ start dying at their 30s? Hard to say! It is hard to study because human 🧠 is the least accessible.

@drneurochic.bsky.social et al discuss how to accelerate biomedical discoveries in brain health via transformative neuropathology.

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8 months ago 1 1 1 0
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Every day is #InternationalWolfDay in our eyes, but today’s a great reminder of how amazing wolves are! 🐺 Support wolf recovery and conservation by donating or advocating for stronger protections. 🌎🐾

Learn more about ways to make an impact: nywolf.org

8 months ago 7474 1527 86 58
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Interested to see how advanced microscopy holds the power to transform our understanding of therapeutics🔬🧠…come see our latest work. #AAIC25

Hall G session 2-3.30 pm integrative neuropathology in ADRD at 2.20 pm sharp

@drneurochic.bsky.social

8 months ago 5 2 0 0
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@alzassociation.bsky.social #GlobalImmersionExperience reception at Thompson Landry Gallery #Toronto

8 months ago 6 1 0 0
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#USPOINTER study #sciencerockstars report #structuredlifestyleintervention improves #cognitiveperformance 🤓💪🏼🥳💜🧠 #ENDALZ

8 months ago 5 2 0 0

NEWSFLASH #2: @alzassociation.bsky.social commits over $40M to translate the positive outcomes of #USPOINTER #structuredlifestyleintervention to preserve your 🧠 💜 # ENDALZ 💪🏼 from global to local.

8 months ago 7 2 0 0
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Incredible achievement! Congratulations!

9 months ago 2 1 0 0

You can still be a grown a** adult and have an "I forgot my homework nightmare" ...There I sat in an audience and they call me as the next speaker and also from stage ask where my talk was😱

double booked today for two talks might have something to do with it😆 I'm excited though and pptx ready 💪

10 months ago 2 0 0 0
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The Neurofibrillary Tangle Maturity Scale: A Novel Framework for Tangle Pathology Evaluation in Alzheimer's Disease Neurofibrillary tangles are dynamic neuropathologic hallmarks of Alzheimer's disease with a hypothesized lifespan morphologically-defined by three maturity levels: pretangles, mature tangles, and ghos...

🧠 New preprint alert! We are excited to present the neurofibrillary tangle maturity scale, which integrates tangle maturity scores of pretangles, mature tangles, and ghost tangles to summarize tangle maturity predilection in the tissue. @drneurochic.bsky.social
www.biorxiv.org/content/10.1...

10 months ago 5 2 0 0

Oh that is definitely frameable, would also consider it fridge worthy with just the right magnet 🤩

10 months ago 8 0 1 0
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Models of autoantibody mediated diseases: actively nearing the human gold standard Human autoantibody-mediated diseases associated with a single autoantigenic target provide several valuable opportunities for precision medicine.1 The impl

academic.oup.com/brain/articl...

My editorial on an actively immunised mouse model of NMDAR antibody encephalitis. Please note my scepticism of clinical trials in this field, towards the end!

10 months ago 4 1 1 0
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Nominate a deserving early-career investigator today for a chance to attend #CCAD2026. If selected, they will compete for a $100,000, 2-year grant from #NewVisionResearch!

View nomination criteria here 👉 newvisionresearch.org/ccad-2026/

Nominate here 👉 airtable.com/appjJE7FUGZY...

11 months ago 1 2 0 0
A picture by edutopia has an older woman with gray hair and an aqua sweater smiling. The quote is,

"You cannot get through a single day without having an impact on the world around you. What you do makes a difference, and you have to decide what kind of difference you want to make."
 -Jane Goodall

A picture by edutopia has an older woman with gray hair and an aqua sweater smiling. The quote is, "You cannot get through a single day without having an impact on the world around you. What you do makes a difference, and you have to decide what kind of difference you want to make." -Jane Goodall

What you do makes a difference.
💚🩷 -E
#GoodNews🏆
#GoodNews 🏆

11 months ago 6 2 1 0

This is so exciting, can't wait to read!

11 months ago 1 0 1 0

Read our latest review article out in @thelancetneuro.bsky.social if you want to know more about CSF transport across the different compartments of the brain-meningeal border and its importance for neurological diseases with strong neuroimmune components 😉
authors.elsevier.com/a/1l7l75FFzL...

11 months ago 32 13 4 0
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Computational Psychiatry Course Zurich An educational course about computational psychiatry from UZH & ETH Zurich.

Learn about (generative) modeling in #ComputationalPsychiatry by attending the #CPCZurich2025.
The BEST course for learning about different models (incl. tutorials), best practices, math backgrounds, and showcase your research in the poster session:
www.translationalneuromodeling.org/cpcourse/

11 months ago 2 2 0 0
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Curse of Neuroanatomy Training Part 4. Tessellation of Mona Lisa, but looks like gyri to us. Thanks to Dr. Jeff Browndyke. Original post by Kevin Atkinson Mathematical Tiling and Tessellation. #neuroskyence

11 months ago 14 4 1 1

Oh that was my very first thought, look at that cool gyral maze 🤩 perspective reveals though just how absolutely beautiful!

11 months ago 2 0 0 0
Searchable database of tangible benefits that federally-funded research gave us. A crowd-sourced site. Health and Well-being. National Security. Prosperity.

ATTENTION

New crowdsourced site collecting and sharing stories of public impact of research

publicusaresearchbenefits.com

Take a look and consider contributing. Let's make this as powerful as possible!

11 months ago 86 65 3 5

quite extraordinary story. Sometimes I think it’s the weird people that will save the world,

11 months ago 69 15 7 0

Oh I have no doubt. I think the more and more we shift from considering individuals as outliers and see how they help to inform medicine and science, The faster we'll be able to tackle all biomedical mysteries. Great find!

11 months ago 1 0 0 0

Nooooo😂😂😂

11 months ago 0 0 0 0
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Today a pupal #Drosophila #Brain (40 h APF)
for #fluorescencefriday.

🔵 Actin
🟠🟡 Anti-E-Cad
depth-coded color

I have 1 million versions of this picture, in which I tried different LUTs. I will put some in the comments!

#microscopy #cellbio #neuroscience #insect

11 months ago 38 9 2 0
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Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

11 months ago 69 28 2 0

Oh my goodness I love it, there was once this whole skit on cool guys don't look at explosions...But apparently Danny DeVito emanates from them 😍

11 months ago 1 0 0 0

BEAUTIFUL and really loving the explanations 👏👏👏

11 months ago 1 0 1 0
Microscopy image of mmunohistochemistry to label tyrosine hydroxylase in human stems cells that are being differentiated

Microscopy image of mmunohistochemistry to label tyrosine hydroxylase in human stems cells that are being differentiated

For #FluorescenceFriday - new experiments that I am really excited for! Really pretty tyrosine hydroxylase (TH) 🟢 labeling in human induced pluripotent stem cells that are differentiating into locus coeruleus-like cells. Image credit to the @lieberinstitute.bsky.social Imaging Development team 🧠🧪🔵

11 months ago 43 5 2 0

This is such a big deal, congratulations 👏👏👏

11 months ago 1 0 1 0