Microglia don’t act the same around the clock! Their transcriptional/proteomic/functional programs shift across sleep/wake phases - yet most studies ignore time-of-day. This perspective calls for a circadian rethink in neuroimmunology!
pubmed.ncbi.nlm.nih.gov/40618264/
Microglia don’t act the same around the clock! Their transcriptional/proteomic/functional programs shift across sleep/wake phases - yet most studies ignore time-of-day. This perspective calls for a circadian rethink in neuroimmunology!
pubmed.ncbi.nlm.nih.gov/40618264/
We are immensely grateful to the donors and their families for their facilitating a research that will advance the field towards understanding, prevention and hopefully cure!
April is #Parkinson's awareness month! PD is the second most common #neurodegenerative disease. Below you see two sections of human midbrain processed in our lab, where you can see the hallmark of PD: #Dopaminergic neuronal death in the SNpc, from where I sort intact #microglia for MultiOmics.
Maternal immune activation may compromise offspring #neurodevelopment via #glia activation. In this chapter, we discuss the most up-to-date evidence and mechanisms gathered via #COVID_19 and other pandemics, preclinical models and brain-organoid models with integrated #microglia.
shorturl.at/0B8Bw
What time do you collect Microglia from preclinical models for downstream analyses? Microglia undergo transcriptional, proteomic and functional adaptations to the wake and sleep phases🧵 shorturl.at/LpEQk
Maternal immune activation may compromise offspring #neurodevelopment via #glia activation. In this chapter, we discuss the most up-to-date evidence and mechanisms gathered via #COVID_19 and other pandemics, preclinical models and brain-organoid models with integrated #microglia.
shorturl.at/0B8Bw
Microglia dysfunction, neurovascular inflammation and focal neuropathologies are linked to IL-1- and IL-6-related systemic inflammation in COVID-19 @natureneuro.bsky.social
www.nature.com/articles/s41...
Indeed! This likely reflects inter-species differences in neurodevelopmental complexity, and hence the need for microglia to assist it.
It's interesting though that humans born w/o microglia (due to mutations in the CSFR gene) have a completely aberrant brain development and don't survive long after birth...
Spatial transcriptomic clocks reveal cellproximity effects in brain ageing
Delighted to share an update to our preprint, reviewed at @elife.bsky.social, and now sent back for re-review.
Colossal work by the team and driven home by @mathiasgua.bsky.social
Quick 🧵 of what's new -
www.biorxiv.org/content/10.1...
Very interesting study showing how Astrocytes in the cerebellum can regulate aggressive behavior!
"Neuron-glial interactions in the cerebellar vermis may play a role in adjusting Purkinje cell excitability and setting the tone of aggression."
go.bsky.app/Eaua5Jk my starter for neuroimmunology
Hi @annamolofskylab.bsky.social
Could you please add me to the list? Thanks for creating the it 😀
Finally got this across the finish line!
We made an isogenic panel of MAPT splicing mutation iPSCs that express high levels of endogenous 4R tau...
...and saw some cool stuff!
👇👇👇
tinyurl.com/38e5d6d2
Big thanks to supporters RCFneuro, Brightfocus, AFTD & UKDRI!
Abstract submission for Stem Cell Models of Neurodegeneration 2025 is open until January 31st 2025! Come register and share your work with us!
scmnd.com
We look forward to hosting you in Edinburgh next year :-)
#neuroscience #iPSC #neurodegeneration #stemcells #dementia #organoids
Microglia are key players in neurodevelopment. It is thus essential to include them in brain organoids to study neurodevelopment, especially to study prenatal immune activation and how it impacts such a delicate process. Thrilled to have participated to this beautiful study. shorturl.at/7M9DU
I feel seen
Any researcher here also looking into glia circadian differences in disease models? Eager to connect amd discuss! We study glia in disease and physiology, but mostly during rodent's sleep phase, as they're often hosted in a light:dark cycle. Hence, are we looking at only half of the picture?
We are recruiting a postdoc!
Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼
📌 $73,588 💰
📌 access to postdoc housing 🏠
📌 Support for internationals 🌍
📌 Awesome view 😅
🙏 RT
labs.icahn.mssm.edu/derubeislab/...
@brainimmunity.bsky.social Could I be added to the list? :)
Thank you so much for creating it!
Hi Bluesky 🦋 I’m Nico, a microglia enthusiast based in VIB, Belgium 🧠 if you are curious about the science we do, take a look at our latest work! Here we use xenotransplantation models to map the spectrum of human microglia responses to Alzheimer’s disease pathology www.nature.com/articles/s41...
Beautiful work! Were animals hosted in a light:dark cycle? We recently showed that many DAM and plaque-associated microglia genes change between the light and dark phase. I wonder what we would see if we extended this kind of transcriptional profiling of microglia to both phases. shorturl.at/icWJD
Hi @liddelowsa.bsky.social
Could I be added to the list? 😀
Thank you for organizing it!
Hi! @mancusorenzo.bsky.social could you add me to the microglia list? Thanks for putting the list together 😀
Any researcher here also looking into glia circadian differences in disease models? Eager to connect amd discuss! We study glia in disease and physiology, but mostly during rodent's sleep phase, as they're often hosted in a light:dark cycle. Hence, are we looking at only half of the picture?
Done :)
Grazie!
Beautiful! Is this a regular thing?
Furthermore, diurnal variations in microglial features may account for within- and between-study variability. Reporting the Zeitgeber time at which microglia are collected may improve reproducibility and comparability of results.