Duration between rewards controls the rate of behavioral and dopaminergic learning - Nature Neuroscience Cue–reward learning rate scales proportionally with the time between rewards. Consequently, learning over a fixed duration is independent of the number of trials. This challenges trial-based dopamine ...

Duration between #rewards controls the rate of #behavioral and #dopaminergic #learning
doi.org/10.1038/s415...

Neuroscientists link a common inflammatory molecule to the dopaminergic mechanisms of addiction Treatments for autoimmune disorders might offer hope for methamphetamine addiction. Research published in Science Signaling indicates that blocking a specific immune protein dampens the drug's effect ...

#Neuroscientists link a common inflammatory #molecule to the #dopaminergic mechanisms of #addiction

www.psypost.org/neuroscienti...

#IL6 deficiency worsens motor deficits and #dopaminergic #neurodegeneration in #ParkinsonsDisease models, with stronger effects in females, while recombinant IL-6 partly rescues motor function and neuronal loss. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

On the mechanisms of dopamine receptor agonists in restless legs syndrome Abstract. Several dopaminergic compounds, including the clinically used pramipexole, are labeled as preferential dopamine D3 receptor (D3R) agonists based

#Dopaminergic pathways are affected in those with #RestlessLegSyndrome (RLS). This study explores the mechanisms of these affects in the #nervoussystem. academic.oup.com/sleep/articl...

VTA dopaminergic neuronal activity during NREM sleep is modulated by learning and facilitates motor memory consolidation Activity of VTA dopaminergic neurons during NREM sleep facilitates motor memory consolidation and is coordinated with spindles.

VTA #dopaminergic #neuronal activity during #NREM #sleep is modulated by #learning and facilitates motor #memory consolidation | Science Advances www.science.org/doi/10.1126/...

Cholinergic modulation of olfactory bulb circuits during odor exposure and discriminative learning. Top left: Schematic of basal forebrain cholinergic projections from the HDB to the OB. In the right panel, major cell types are labeled. Within the glomerular layer, excitatory OSN axons innervate the MTCs, as well as inhibitory SACs and granule cells. Cholinergic input (ChAT-positive; maroon) innervates multiple cell types. Cholinergic input to the SACs is highlighted. Top right: Circuit diagram showing SAC-mediated inhibition of OSN input. SACs express tyrosine hydroxylase (TH), glutamate decarboxylase 1 (GAD1), and muscarinic receptor CHRM2. Cholinergic input from the HDB acts on SACs to regulate inhibition of sensory input. Bottom: Cholinergic–SAC interactions under different learning conditions. (i) Passive exposure: Cholinergic input modestly recruits SAC activity, with increased TH expression, broadly modulating OSN input. (ii) Discriminative learning: In the naïve state, SAC connectivity and cholinergic modulation are uniform across glomeruli. After training (CS+ vs. CS− discrimination), SAC molecular markers (TH, CHRM2) are upregulated selectively in CS+ associated glomeruli, enhancing cholinergic modulation and reciprocal inhibition to the OSNs. For rewarded odor, cholinergic input strongly inhibits SACs and disinhibits OSN–MTC pathways, amplifying CS+ responses. In the punished condition, SAC-mediated inhibition is maintained for CS− glomeruli, suppressing responses.

#DiscriminativeLearning enhances #sensory contrast for rapid, accurate decisions, but how? This study describes a sensory- #forebrain circuit centered on #dopaminergic short axon cells in the mouse #olfactory bulb, which refines sensory input during learning @plosbiology.org 🧪 plos.io/4pvost3

Cholinergic modulation of olfactory bulb circuits during odor exposure and discriminative learning. Top left: Schematic of basal forebrain cholinergic projections from the HDB to the OB. In the right panel, major cell types are labeled. Within the glomerular layer, excitatory OSN axons innervate the MTCs, as well as inhibitory SACs and granule cells. Cholinergic input (ChAT-positive; maroon) innervates multiple cell types. Cholinergic input to the SACs is highlighted. Top right: Circuit diagram showing SAC-mediated inhibition of OSN input. SACs express tyrosine hydroxylase (TH), glutamate decarboxylase 1 (GAD1), and muscarinic receptor CHRM2. Cholinergic input from the HDB acts on SACs to regulate inhibition of sensory input. Bottom: Cholinergic–SAC interactions under different learning conditions. (i) Passive exposure: Cholinergic input modestly recruits SAC activity, with increased TH expression, broadly modulating OSN input. (ii) Discriminative learning: In the naïve state, SAC connectivity and cholinergic modulation are uniform across glomeruli. After training (CS+ vs. CS− discrimination), SAC molecular markers (TH, CHRM2) are upregulated selectively in CS+ associated glomeruli, enhancing cholinergic modulation and reciprocal inhibition to the OSNs. For rewarded odor, cholinergic input strongly inhibits SACs and disinhibits OSN–MTC pathways, amplifying CS+ responses. In the punished condition, SAC-mediated inhibition is maintained for CS− glomeruli, suppressing responses.

#DiscriminativeLearning enhances #sensory contrast for rapid, accurate decisions, but how? This study describes a sensory- #forebrain circuit centered on #dopaminergic short axon cells in the mouse #olfactory bulb, which refines sensory input during learning @plosbiology.org 🧪 plos.io/4pvost3

Cholinergic modulation of olfactory bulb circuits during odor exposure and discriminative learning. Top left: Schematic of basal forebrain cholinergic projections from the HDB to the OB. In the right panel, major cell types are labeled. Within the glomerular layer, excitatory OSN axons innervate the MTCs, as well as inhibitory SACs and granule cells. Cholinergic input (ChAT-positive; maroon) innervates multiple cell types. Cholinergic input to the SACs is highlighted. Top right: Circuit diagram showing SAC-mediated inhibition of OSN input. SACs express tyrosine hydroxylase (TH), glutamate decarboxylase 1 (GAD1), and muscarinic receptor CHRM2. Cholinergic input from the HDB acts on SACs to regulate inhibition of sensory input. Bottom: Cholinergic–SAC interactions under different learning conditions. (i) Passive exposure: Cholinergic input modestly recruits SAC activity, with increased TH expression, broadly modulating OSN input. (ii) Discriminative learning: In the naïve state, SAC connectivity and cholinergic modulation are uniform across glomeruli. After training (CS+ vs. CS− discrimination), SAC molecular markers (TH, CHRM2) are upregulated selectively in CS+ associated glomeruli, enhancing cholinergic modulation and reciprocal inhibition to the OSNs. For rewarded odor, cholinergic input strongly inhibits SACs and disinhibits OSN–MTC pathways, amplifying CS+ responses. In the punished condition, SAC-mediated inhibition is maintained for CS− glomeruli, suppressing responses.

#DiscriminativeLearning enhances #sensory contrast for rapid, accurate decisions, but how? This study describes a sensory- #forebrain circuit centered on #dopaminergic short axon cells in the mouse #olfactory bulb, which refines sensory input during learning @plosbiology.org 🧪 plos.io/4pvost3

Cognitive effects of dopaminergic treatment in Alzheimer's disease: Systematic review and meta‐analysis INTRODUCTION Despite advances in disease-modifying drugs, better treatments for symptomatic Alzheimer's disease (AD) are needed, with dopaminergic neurotransmission representing a potential target. ...

Meta-analysis examining #dopaminergic treatment in #Alzheimer's disease led by Cristina & Mike with support from others including @suzanne-reeves.bsky.social. More to think about & more on this topic from us soon! #alzheimers #dopamine #dementia alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

How can ventral midbrain #organoid derived from human pluripotent stem cells help to understand the #dopaminergic system and its pathologies?
@fiorenzano.bsky.social and collaborators review recent advances, remaining challenges, and emerging opportunities
www.embopress.org/doi/full/10....

Behavioural impairments in a mouse model of Kabuki syndrome associated with dopaminergic and neuroinflammatory modulations | Acta Neuropsychiatrica | Cambridge Core Behavioural impairments in a mouse model of Kabuki syndrome associated with dopaminergic and neuroinflammatory modulations - Volume 37

🧠New insights into the mechanism for the motor and #immune deficits of Kabuki syndrome

Bapa mice show ↑striatal TH, GFAP, IBA-1—linking #dopaminergic hyperactivity & #neuroinflammation.

The strain is a promising model to study motor & immune deficits

doi.org/10.1017/neu....

April is #Parkinson's awareness month! PD is the second most common #neurodegenerative disease. Below you see two sections of human midbrain processed in our lab, where you can see the hallmark of PD: #Dopaminergic neuronal death in the SNpc, from where I sort intact #microglia for MultiOmics.

SciTech Chronicles. . . . . . . . .Mar 10th, 2025 Everybody Hurts... Sometime. Vol II No 62 195 links Curated More plant oils, less butter could lead to better health. https://www.sciencedai...

SciTech Chronicles. . . . . . . . .Mar 10th, 2025

bit.ly/stc031025

#cancer #cardiovascular #saturated #unsaturated #fMRI #prefrontal #frontoparietal #ganglia #fMRI #prefrontal #frontoparietal #ganglia #dopamine #iPSCs #dopaminergic #immunosuppressive #theoretical #voltage #Hydrogen #Oxygen

Frontiers | Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep

🚨New #Discovery in #Sleep #Science!🧠💤TAAR2-9 knockout mice show disrupted sleep patterns & #Dopaminergic changes—could this be a game-changer for sleep disorders?🤯Frontiers Frontiers in Psychiatry 📢 #Neuroscience #SleepScience #TAAR #BrainResearch
Curious? 🔬👇
doi.org/10.3389/fpsy...

Frontiers | Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep

🚨New #Discovery in #Sleep #Science!🧠💤TAAR2-9 knockout mice show disrupted sleep patterns & #Dopaminergic changes—could this be a game-changer for sleep disorders?🤯Frontiers Frontiers in Psychiatry 📢 #Neuroscience #SleepScience #TAAR #BrainResearch
Curious? 🔬👇
doi.org/10.3389/fpsy...

Changes in dopaminergic neurons linked to SARS-CoV-2 Researchers investigated molecular changes in dopaminergic neurons derived from hPSCs linked to SARS-CoV-2 infection.

#SARS-CoV-2 infection triggers the cellular senescence pathway in susceptible #dopaminergic neurons derived from human pluripotent stem cells (increased risk of viral-induced #parkinsonism?)

discovermednews.com/changes-in-d...

📣 New preprint from Team Calakos examined the role of inhibitory synaptic inputs in mediating #dopaminergic #physiology and vulnerability. Read more on how the team used a novel technology called DART. 🧪
www.biorxiv.org/content/10.1...

#Food wanting is mediated by transient activation of #dopaminergic signaling in the honey #bee brain:

academic.oup.com/jee/advance-article/doi/...