This #STTT study introduces a bimetallic nanobomb that activates the STING pathway and boosts BiTEs-mediated #PhotothermalTherapy, effectively remodeling the #Immunosuppressive #TumorMicroenvironment in #ColorectalCancer.
#OpenAccess: doi.org/10.1038/s413...
Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.
#OpenAccess: doi.org/10.1016/j.ge...
This review highlights GOT2’s dual metabolic and #immunosuppressive roles in #PancreaticCancer, discusses current inhibitor strategies and model discrepancies, and outlines challenges & future directions for targeting GOT2 to improve therapy.
#OpenAccess: doi.org/10.1016/j.ge...
#MASLD increases #PDAC risk & #livermetastasis by creating an #immunosuppressive niche driven by the MIF–CD44 axis, which enhances PDAC cell migration, stemness, and adhesion, while MIF inhibition reduces #metastasis, highlighting a targetable pathway.
#STTT: doi.org/10.1038/s413...
This #STTT study reveals that #ExtracellularVesicle-derived #miRNA1825p induces an #Immunosuppressive macrophage phenotype in #PancreaticCancer, identifying a key mechanism of #ImmuneEvasion and a novel #TherapeuticTarget. #Medsky
#OpenAccess: doi.org/10.1038/s413...
A #PhotodynamicTherapy (PDT) platform inhibiting CCL5 shows efficient drug accumulation & disruption of the #Immunosuppressive #TumorMicroenvironment enhancing the therapeutic efficacy against #BreastCancer & #Melanoma.
#STTT #OpenAccess: doi.org/10.1038/s413...
#Chemotherapy alters #GutBacteria, increasing the #MicrobialMetabolite indole-3-propionic acid, which travels to the #BoneMarrow to reduce #immunosuppressive cells and limit #CancerMetastasis.
#MASLD fosters an #immunosuppressive niche that accelerates #PancreaticCancer liver metastases via the MIF‑CD44 axis, with IPG1576 attenuating progression, highlighting a therapeutic strategy for #PDAC patients with MASLD.
#OpenAccess in #STTT: doi.org/10.1038/s413...
miR-182-5p cargo in #PancreaticCancer #ExtracellularVesicles suppresses TLR4 and activates JAK/STAT3, skewing macrophages to an M2-like state and creating an #immunosuppressive #TumorMicroenvironment. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
Scientists identify MMP1+ cells as transitional drivers preserving ductal identity in #PDAC and S100A2+ tumor subsets as mediators of #LymphNodeMetastasis, while CCL2+ #macrophages & OMD+ fibroblasts shape an #immunosuppressive microenvironment.
#OpenAccess: doi.org/10.1016/j.ge...
Integrated transcriptomics & bulk sequencing shows that SPP1+ macrophages drive #ColorectalCancer via pro-angiogenic & #Immunosuppressive pathways, highlighting them as potential #PrognosticBiomarkers & #TherapeuticTargets.
#OpenAccess: doi.org/10.1016/j.ge...
[177Lu]Lu-DUNP19, an LRRC15-targeting mAb-based #RadioTheranostic platform enables non-invasive detection, targeting, and reprogramming of #Immunosuppressive gene signatures within tumors. #MedSky @uofcalifornia.bsky.social
#STTT #OpenAccess: doi.org/10.1038/s413...
A self-assembling #photosensitizer, Ce6-GFFY, targets #ColorectalTumors and, upon light activation, generates #ROS to induce immunogenic cell death, enhance #CytotoxicTCells, suppress #immunosuppressive cells, and inhibit #MetastaticTumor growth.
OpenAccess: doi.org/10.1016/j.ge...
Increased PLXNC1 expression in CRC tissues correlates with tumor aggressiveness, poor #Prognosis, and an #Immunosuppressive #TumorMicroenvironment, highlighting it as a potential #Biomarker and #TherapeuticTarget.
#OpenAccess: doi.org/10.1016/j.ge...
Radio-theranostic targeting of LRRC15 with [177Lu]Lu-DUNP19 improves survival and reprograms the pro-tumorigenic and #Immunosuppressive transcriptomic landscape of the #TumorMicroenvironment. @uclacollege.bsky.social
#OpenAccess: doi.org/10.1038/s413...
#OncostatinM induced by STAT5-activating #oncogenes triggers STAT-3-mediated proinflammatory signaling, resulting in #MetabolicReprogramming, enhanced cytokine secretion, and recruitment of #Immunosuppressive myeloid cells in blood malignancies.
#OpenAccess: doi.org/10.1038/s413...
Kidney Tertiary #LymphoidTissues and Poor #Immunosuppressive Response in #IgANephropathy #IgAN
#VisualAbstract by Elba Medina
www.kireports.org/article/S2468-0249(25)00...
🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.
Figure 1 Chronic UVR exposure impacts peripheral immunity - panel L - CD4+FOXP3+ cells in CD3+ gate,All immune populations determined by flow cytometry in the peripheral blood of UVR mice (n=20) exposed to 6 weeks of UVR and non-UVR (n=19) matched controls.
WHAT THIS STUDY ADDS
⇒ Authors show that systemic UVR exposure increases circulating regulatory T cells ( #Tregs ) & induces an #immunosuppressive signature within #colorectal and #melanoma mouse tumors, thereby impairing the efficacy of #immunotherapy
Targeting LRRC15⁺ cells with [¹⁷⁷Lu]Lu-DUNP19 enables precise imaging and #radiotherapy, reprograms the #immunosuppressive #TumorMicroEnvironment & offers a strategy against #TreatmentResistant #cancers. @uofcalifornia.bsky.social
#FeaturedArticle #STTT: doi.org/10.1038/s413...
⏱️ Live Feed: Dr. Monica Olcina (University of Oxford, UK) discussed how targeting the #complement receptor #C5aR1 could enhance #radiotherapy efficacy in #immunosuppressive tumor #microenvironments.
Neoleukin-2/15-armored mesothelin-specific CAR-NK cells resist #immunosuppressive polarization and exhibit longer persistence within the TME, offering superior therapeutic efficacy in solid tumors. #medsky
#STTT #OpenAccess: doi.org/10.1038/s413...
First up, there are clinical effects: #Vaccine response was especially poor soon after #transplantation, and in patients on #immunosuppressive cocktails, especially those including MMF.
Even taking this into account, there were immunological drivers associated with poor response.
3/6
IGF2BPs as novel m6A readers: Diverse roles in regulating cancer cell biological functions, hypoxia adaptation, metabolism, and immunosuppressive tumor microenvironment
This review describes the structure of IGF2BPs, the mechanisms regulating IGF2BPs in #cancer, and their role in the #immunosuppressive #TumorMicroenvironment, with highlights on their potential as diagnostic & prognostic #Biomarkers. #Epigenetics #medsky
#OpenAccess: buff.ly/skDnpNI
Colony-stimulating factor-1 receptor inhibition combined with paclitaxel exerts effective antitumor effects in the treatment of ovarian cancer
Co-treatment with PLX3397, a CSF1R inhibitor, and paclitaxel significantly inhibits the growth of #OvarianCancer by altering #MacrophagePhenotypes and reprogramming the #immunosuppressive cell population in the #TumorMicroenvironment. #medsky
#OpenAccess: www.sciencedirect.com/science/arti...
PMN-MDSCs Orchestrate the #Immunosuppressive Microenvironment in the Lung and Are Associated With Clinical Outcome in #Bronchiectasis
onlinelibrary.wiley.com/doi/10.1111/...
THE FEBRUARY ISSUE IS NOW AVAILABLE!!
Check it out here: bit.ly/41YnD10
@esottransplant.bsky.social @frontiersmedia.bsky.social
#immunosuppressive #therapy #liver #transplantation #kidney #protection
“Anti-TNFα as an Adjunctive Therapy in Pancreas and Kidney Transplantation”
Read more: bit.ly/4kV8bvi
#pancreas #kidney #transplantation #antiTNF #TNF #immunosuppressive #therapy
@esottransplant.bsky.social
link.springer.com/article/10.1...
AXL: shapers of tumor progression and immunosuppressive microenvironments
#AXL 's role in tumor progression and #immunosuppressive microenvironments; influence on immune cells, tumor cells, stromal cells, and contributes to cancer drug resistance and metastasis.
SciTech Chronicles. . . . . . . . .Mar 10th, 2025
bit.ly/stc031025
#cancer #cardiovascular #saturated #unsaturated #fMRI #prefrontal #frontoparietal #ganglia #fMRI #prefrontal #frontoparietal #ganglia #dopamine #iPSCs #dopaminergic #immunosuppressive #theoretical #voltage #Hydrogen #Oxygen
