Boosting pancreatic cancer chemotherapy via nerve–cancer crosstalk
www.scienceopen.com/hosted-docum...
#PancreaticCancer #Chemotherapy #TumorMicroenvironment #Neurobiology #CancerTherapeutics

This review highlights aberrant #neddylation as a driver of #HepatocellularCarcinoma, influencing infection, #tumor growth, invasion, and the #TumorMicroenvironment, while assessing inhibitors like MLN4924 & TAS4464 as promising #HCC therapies.

#OpenAccess: doi.org/10.1016/j.ge...

This review highlights #HER3 as a key #oncogenic driver shaped by #TumorMicroenvironment signals, stressing the need for predictive #biomarkers, novel ADCs, and combination strategies to boost HER3-targeted #cancer therapies. @cwru.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...

This review shows how #RNAbindingProteins and #circularRNAs form regulatory networks driving #tumor traits like #metastasis & #DrugResistance, offering therapeutic insights via RNA technologies to reshape the #TumorMicroenvironment.

#OpenAccess: doi.org/10.1016/j.ge...

Preprint alert! 🚨

www.preprints.org/manuscript/2...

High-grade soft tissue sarcomas (STS) lack robust biomarkers—but we may have a new signal.

#Sarcoma #Immunology #CancerResearch #TumorMicroenvironment #Biomarkers #Oncology

IL-7 agonist #EfineptakinAlfa (NT-I7) reshapes the #TumorMicroenvironment, expanding T, B, DC, and stem-like CD8 T cells while inducing TLS-like aggregates enriched in PD-L1, suggesting synergy with #PD1blockade.

#OpenAccess: doi.org/10.1016/j.ge...

Researchers @roswellpark.bsky.social show that the #Exocyst complex mediates fungal-induced IL-33 release from #Cancer cells, identifying a novel secretory mechanism that links fungal-induced immune signaling to #TumorMicroenvironment modulation.

#OpenAccess: doi.org/10.1038/s413...

This #STTT study introduces a bimetallic nanobomb that activates the STING pathway and boosts BiTEs-mediated #PhotothermalTherapy, effectively remodeling the #Immunosuppressive #TumorMicroenvironment in #ColorectalCancer.

#OpenAccess: doi.org/10.1038/s413...

🚨 Few spots left!
Join the 7th International Conference on #Cytokines in #Cancer
📅 May 17–22, 2026
📍 Sissi, Crete, Greece
Topics: cytokines & cell communication, inflammation and cancer, #tumormicroenvironment, #irAEs, and therapies.
Register: www.aegeanconferences.org/src/App/conf...

Weekly reads 23/2/26 When context controls cancer: oxygen, space, niches and chromatin

Weekly reads 23/2/26:
When context controls cancer: oxygen, space, niches and chromatin
open.substack.com/pub/behindth...

Cancer isn’t just mutations: it’s metabolism, space, niches, and chromatin.

#CancerResearch #SingleCell #SpatialBiology #TumorMicroenvironment #PrecisionOncology

🎉 Excited to share our cover article in Cancer Research!
We identified distinct tumor‑immune ecologies in lung cancer that predict immunotherapy response—moving beyond single biomarkers to spatial interactions. #CancerResearch #Immunotherapy #TumorMicroenvironment #Biomarkers
Paper: t.co/cLLk8JX4UH

CANCER METABOLISM REVIEW: Metabolic permissiveness: how tissue context shapes cancer
By Chrysanthi Moschandrea and Christian Frezza
➡️ https://genesdev.cshlp.org/content/40/5-6/287.full

Christian Frezza CECAD Cologne Universität zu Köln
#cancermetabolism #tumormicroenvironment

Last week, CSI Singapore hosted Prof. Hiroyoshi Nishikawa from National Cancer Center (NCC) Japan. He spoke on the topic “Immuno-genomic Analysis Elucidates Immunosuppressive Mechanisms in the Tumor Microenvironment”.

#tumormicroenvironment #cancerimmunology #Immunogenomics #cancerresearch

Using integrated #scRNAseq, #Immunofluorescence, and functional validation, this study shows that the #Immunosuppressive #TumorMicroenvironment contributes to tumor aggressiveness in lymphovascular invasion-positive #PDAC.

#OpenAccess: doi.org/10.1016/j.ge...

This review provides insights into #Epigenetic alterations in #Cancer and the #TumorMicroenvironment, outlining their roles in tumor progression and the therapeutic potential of epigenetic drugs and combination strategies.

#OpenAccess: doi.org/10.1016/j.ge...

Study finds stress-related nerves may fuel pancreatic cancer growth – BioNews Central New research has revealed that certain nerves involved in the body’s “fight or flight” stress response can support the growth of pancreatic cancer. ...

New research has revealed that certain #nerves involved in the body’s “fight or flight” #StressResponse can support the growth of #PancreaticCancer.
#SympatheticNerves #TumorGrowth #TumorMicroenvironment

This #STTT study identified glycolytic heterogeneity within the #PDAC #TumorMicroenvironment and proposes a novel glycolysis-based framework for patient stratification to guide personalized medicine & #PrecisionOncology.

#OpenAccess: doi.org/10.1038/s413...

Thanks to Gertraud Orend for a great #seminar today! Her talk highlighted that targeting tenascin-C in the #TumorMicroenvironment can improve #therapy responses.
#CancerResearch @3r-network-bw.bsky.social

The dysadherin/CA9 axis shapes an acidic tumor microenvironment to promote colorectal cancer progression.
Microenvironmental acidity as a driver of malignancy.
doi.org/10.1038/s413...
#ColorectalCancer #TumorMicroenvironment #CA9 #Dysadherin #TumorAcidity #CancerProgression

Inhibin beta A drives colorectal cancer progression through macrophage M2 polarization and mitochondria-dependent ferroptosis suppression.
Tumor–immune crosstalk meets cell death control.
doi.org/10.1038/s413...
#ColorectalCancer #TumorImmunology #Ferroptosis #TumorMicroenvironment

Graphical summary of SMLR1 in colorectal cancer liver metastasis. Primary colon tumor cells metastasize to the liver, where SMLR1 expression increases. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting macrophage polarization toward an immunosuppressive, pro-tumoral phenotype. The diagram highlights immune suppression and enhanced tumor growth within the liver-specific metastatic niche.

📖 Commentary Spotlight
In the inaugural issue, Liu discusses how SMLR1 reshapes the liver metastatic niche through macrophage polarization, highlighting its role in cancer plasticity and immune modulation.
🔗 www.pivotscipub.com/chp/1/1/0002...
#CancerHeterogeneity #TumorMicroenvironment

Graphical abstract illustrating colorectal cancer liver metastasis. Cancer cells in the colon metastasize to the liver, where they upregulate SMLR1. SMLR1 interacts with macrophage receptors MRC1 (CD206) and SIGLEC1 (CD169), promoting tumor–macrophage interactions within the liver microenvironment. Legend indicates cancer cells (green), macrophages (beige), and molecular interactions.

📘 CHP Archive Spotlight #02
Original Research (2024) | Wong et al.

📢 New mechanistic insight in CRC liver metastasis:
Cancer cells upregulate SMLR1 to engage immunosuppressive TAMs, reshaping the liver niche.

🔗 www.pivotscipub.com/chp/1/1/0003...
#ColorectalCancer #TumorMicroenvironment

#Hypoxia-driven antigen loss and #VEGF secretion drive resistance to MUC16-targeted BITEs in #OvarianCancer, while VEGF blockade restores #cytotoxicity, highlighting #TumorMicroenvironment targeting to boost BITE immunotherapy. @harvardmed.bsky.social

#STTT: doi.org/10.1038/s413...

Don't miss her talk!

🗓 When: June 28 – July 1, 2026
📍 Where: Salt Lake City, Utah
👉 Become a member & Save: metastasis-research.org/membership-a...

#MRS2026 #EvanthiaRoussosTorres #BreastCancer #Immunotherapy #TumorMicroenvironment #Metastasis #USC #WomenInScience

Created by Dr. Spencer Watson uses hyperplexed immunofluorescence data. This work shows how microscopy and computer vision can be combined to better understand complex cellular systems.

#sciart #microscopy #computervision #cancerbiology #tumormicroenvironment #immunofluorescence #artinscience

FEBS Press This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial-to-mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP-binding pa....

What if the extracellular matrix actively reprograms TGFβ signaling to drive metastasis?

Our new study reveals that the COMP–PMEPA1 axis promotes EMT and shifts signaling toward pSMAD1/5 in breast cancer cells.

🔗 doi.org/10.1002/1878...
#BreastCancer #EMT #CancerBiology #TumorMicroenvironment

Tumor Microenvironment Research Summary January 2026 - Summarized Science Summary of key Tumor Microenvironment publications highlighting major findings, clinical relevance, and emerging research trends.

🧬 Tumor Microenvironment — Jan 2026

• Engineered CAR-T and TAM targeting reshape local immunity
• Fibroblast checkpoints and macrophage signaling drive resistance
• DNA sensing and pyroptosis pathways amplify immunotherapy response

pir.sh/9XygJPXd3w

#TumorMicroenvironment #CancerImmunology #TAMs

This #STTT review outlines the advanced engineering and combination strategies for #OncolyticViruses to enhance their ability to selectively lyse #MalignantCells and reprogram the #TumorMicroenvironment for #SystemicImmunity.

#OpenAccess: doi.org/10.1038/s413...

🌐 Join @keystoneSymposia.bsky.social #TumorMicroenvironment: Drivers of Progression & #Resistance, this May in Whistler 🚠 JEM's @zhijuanjexpmed.bsky.social is attending!
Don't miss deadlines for abstract, scholarship, early reg 👉 www.keystonesymposia.org/conferences/...

#KSTumorMicro26

This review on #AngioimmunoblasticTcellLymphoma highlights #epigenetic dysregulation, signaling changes, #TumorMicroenvironment interplay, prognostic models, and evolving epigenetic therapies. @fudan-university.bsky.social

#OpenAccess: doi.org/10.1016/j.ge...