Researchers @roswellpark.bsky.social show that the #Exocyst complex mediates fungal-induced IL-33 release from #Cancer cells, identifying a novel secretory mechanism that links fungal-induced immune signaling to #TumorMicroenvironment modulation.

#OpenAccess: doi.org/10.1038/s413...

So excited to see this out now! #exocyst

Continuum architecture dynamics of vesicle tethering in exocytosis Data from complementary imaging techniques were integrated into a model that resolves the dynamic exocyst ensemble and membrane architecture during exocytosis, an essential cellular pathway. Sec18 med...

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🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology

Continuum architecture dynamics of vesicle tethering in exocytosis
www.cell.com/cell/fulltex...

The autophagy-specific exocyst subcomplex contributes to phagophore assembly site integrity by promoting phagophore expansion | PNAS Autophagy is a crucial intracellular pathway for maintaining cellular homeostasis. It involves forming double-membrane vesicles called autophagosom...

Thrilled to share that my PhD work has been published @pnas.org

#Exocyst #autophagy #membrane expansion #yeast genetics

We are grateful to the editorial team for their efficient handling of the manuscript and to the reviewers for their constructive feedback.

www.pnas.org/doi/10.1073/...

Proposed working model for the role of OsSEC3A in regulating crown root development.

OsSEC3A, a key #exocyst subunit, is required for the emergence of crown root in #rice

Jianshu Zhu, et al.

nph.onlinelibrary.wiley.com/share/ZHKP7A...

#PlantScience

Electrostatic changes enabled the diversification of an exocyst subunit via protein complex escape - Nature Plants The evolutionary diversification of an exocyst subunit was enabled by electrostatic shifts leading to its dissociation from the ancestral complex.

My main work as postdoc @plantophagy.bsky.social lab in @gmivienna.bsky.social is out in @natplants.nature.com 🌱🎉

We asked how can protein complexes diversify without compromising their function and explored this question using the plant #exocyst complex.

www.nature.com/articles/s41...

To tackle this, we focus on the #exocyst, an ancient 8-subunit trafficking complex.
One subunit, Exo70, has undergone explosive diversification across land plants. How did Exo70 escape the constraints of the complex to explore new functions?