🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.

Directed protein engineering identifies a human TIM-4 blocking antibody that enhances anti-tumor response to checkpoint inhibition in murine colon carcinoma Statement of Significance: We developed a rapid antibody discovery program using directed-protein engineering to develop a first in class anti-human T-cell

New article “Directed protein engineering identifies a human TIM-4 blocking antibody that enhances anti-tumor response to checkpoint inhibition in murine colon carcinoma” contributed by Karla Frietze Miller, Ph.D. from Skunkworx Bio.

doi.org/10.1093/abt/...

#mAbs #TIM4 #Oncology