🔥Hot Off the Press | Cancer suppresses the mitochondrial chaperone #TRAP1 in tumor-associated macrophages, boosting their #immunosuppressive activity and enabling immune escape. Restoring TRAP1—via #TIM4 or #JMJD3 targeting—reprograms #TAMs and enhances antitumor immunity.

TRAP1 moonlights as an RNA-binding protein, enhancing translation of the splicing factor LUC7L3 to drive proliferation in high-grade serous ovarian cancer cells. #TRAP1 #RBP #ovariancancer bit.ly/47t3apu