A graphic with a blue background features a white quote: "Preclinical studies currently rely on in vivo animal models, including transgenic and aged specimens...[brain organoids]-based research aims to reduce the use of these models, facilitating faster and easier scaling of therapeutic interventions for AD...[and] serve as valuable ex vivo targets for monitoring pharmacological interventions during disease progression, offering insights that may lead to personalized therapies.” Below the text, a citation appears in small white font: "Dolciotti C, Righi M, Grecu E, et al. The translational power of Alzheimer's-based organoid models in personalized medicine: an integrated biological and digital approach embodying patient clinical history. Front Cell Neurosci. 2025;19:1553642. doi:10.3389/fncel.2025.1553642.” In the lower right corner, there is a colorful illustration of a human brain model divided into regions: yellow, pink, blue, purple, orange, and red.
🧠 This mini review explores how #organoids from patient-specific #iPSCs mimic the structural & functional complexities of the human brain, as well as be used to study AD pathology.
🏛️ @unipisa.bsky.social
www.frontiersin.org/journals/cel...
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