Our new paper is out! 🎉
Let-7 doesn’t act through a single pathway: it controls neocortical neuron fate and migration via distinct downstream mechanisms, with RBX2 dedicated to migration. A new layer of post-transcriptional control shaping cortical development
www.pnas.org/doi/10.1073/...
In this new #Review, Chiara Anna Giordani (@ucdcpmds.bsky.social) and @clancyatheart.bsky.social discuss #dose as a fundamental organizing principle in physiology. 💉 💊
🔗 Read it here:
www.sciencedirect.com/science/arti...
💡 Key insight: Preserving PIP3 signaling through PTEN inhibition protects against cardiac dysfunction and fibrosis, highlighting a potential therapeutic opportunity.
But this adaptation proves insufficient. Chronic angiotensin II still drives hypertrophy, t-tubule disruption, fibrosis, and diastolic dysfunction.
The researchers found widespread phosphoinositide imbalance and internalization of L-type CaV1.2 calcium channels from t-tubules into endosomal compartments. Yet remarkably, calcium currents are preserved through compensatory PKA and CaMKII signaling.
Compelling new study by @maartjewesthoff.bsky.social, Taylor Voelker, @roseedixon.bsky.social et al. This latest work in Circulation Research explores what happens when angiotensin II signaling becomes chronic. www.ahajournals.org/doi/10.1161/...
This new @pnas.org paper by Yuhua Tian from #PMB Zheng Lab, et al, uncovers TRPM4 as the hub to four major signaling systems. The study reveals how PIP₂ “locks/unlocks” channel activity, helping explain organ-specific diseases from TRPM4 mutations. www.pnas.org/doi/10.1073/...
Beat-locked ATP microdomains in the sinoatrial node map a Ca2+-timed energetic hierarchy and regional pacemaker roles. New study from Manuel F. Muñoz, Fernando Santana @lfsantana68.bsky.social and colleagues @ucd-physiology.bsky.social rupress.org/jgp/article/...
#IonChannels #CardiacMuscle
Congratulations on this grant @vyy-sf.bsky.social !!
Congrats to Vladimir Yarov-Yarovoy on the GenScript Life Science Research Grant for his AI-driven drug discovery work!
His research on ion channels could help treat arrhythmias and neuropathic pain. Selected from 500+ applications, an outstanding achievement!
Muñoz, @lfsantana68.bsky.social et al. show that beat-locked cytosolic and mitochondrial ATP transients in sinoatrial node myocytes sort into high-gain, low-gain, or consumption-dominant modes aligned with superior–inferior vascular–mitochondrial gradients. rupress.org/jgp/article/...
#CardiacMuscle
Deep learning as a generator of sodium channel state hypotheses. Lisa Schmidt and Wojciech Kopec @mpi-nat.bsky.social discuss recent work by Lopez-Mateos, Narang, and @vyy-sf.bsky.social @ucd-physiology.bsky.social (rupress.org/jgp/article/...) in Commentary: rupress.org/jgp/article/...
#IonChannels
The team went to the #biophysical and #modeling side to understand how the CaBP1 protein regulates L-type channels. Great collab with Jim Ames, Hell Lab & #MnMLab
@ucdavis.bsky.social
pubs.acs.org/doi/10.1021/...
🧪New collaborative paper with the new lab of @henninglanger.bsky.social
Weight loss with GLP-1 medicines does not result in a disproportionate loss of muscle mass or function in obese mice and humans: Cell Reports Medicine www.cell.com/cell-reports...
Earlier this year, I was selected as a ‘26 Frontiers of Science Fellow by @nasonline.org, which led to my participation in the 2026 FoS Symposium. The meeting was such a fun and unique experience! I’ve never been to a meeting where people from such differing fields were convened to share ideas.
Reminder for @ucdavis.bsky.social early career faculty! Tomorrow is the first of our NSF CAREER infosessions! #academicsky #nsfcareer #nsffunding #grantwriting
A new #PMB paper @JPhysiol reveals beat-to-beat ATP dynamics. Imaging shows mitochondrial ATP waves synchronized with contraction and distinct energetic strategies in male vs. female heart cells. Congratulations Paula Rhana, Collin Matsumoto, @lfsantana68.bsky.social
🩸 Plot twist! Nosebleeds in hereditary hemorrhagic telangiectasia aren't just leaky pipes - VSM that surround and control them are secretly breaking down too!
New in @CircRes 🔥 Great collab @ucdavishealth.bsky.social with Rong Wang @ucsfhealth.bsky.social
www.ahajournals.org/doi/10.1161/...
Dr. Vladimir Yarov Yarovoy attended the 2nd World Sodium Channel Conference in Grindelwald, Switzerland, and presented a recently published research project entitled “Exploring voltage-gated sodium channel conformations and protein–protein interactions using AlphaFold2”
Someone got really great news from @ahascience.bsky.social on his Career Development Award. Congrats Miguel!!!
#proudmentors
@ucdavis.bsky.social, @ucdavishealth.bsky.social
Diego Lopez Mateos, postdoctoral researcher at the Center for Precision Medicine and Data Science at UC Davis, presented both a platform talk and a poster at the 2026 Biophysical Society Annual Meeting at San Francisco in the "Ion Channel Regulation, Pharmacology and Disease"
Join us during #BiophysicsWeek for the JUST-B Spring Seminar! We're highlighting the work of two trainees who have participated in the JUST-B Poster Session.
Tuesday, March 24, 2026
2:00 PM - 3:00 PM
buff.ly/6YMcw4o
Writing away surrounded by American robins and cedar waxwings all morning, feasting on berries. #backyard_birding
Our lab is hiring a research technician! We are interested in reproduction, stem cells, and development. If you are seeking a robust 2-year career experience before the next chapter of your educational journey, this is the position for you!
hhmi.wd1.myworkdayjobs.com/en-US/Extern...
Starting a new lab and trying to navigate your science, papers, grants, and institutional duties? Want to meet people in the same situation and connect with established scientists who can their perspectives? Join the SGP-JGP Junior Faculty Network! sgpweb.org/programs/jfn.
Check out the latest @physrep.bsky.social cover image and article from #PMB Zavorsky Lab, "Calculating pulmonary shunt fraction using standard clinical measurements", by Gerald Zavorsky et al.: doi.org/10.14814/phy...
Thermal medicine, the controlled use of heat and cold has been part of healing traditions for millennia. Now, thanks to new sensors, wearables, and AI, researchers can track individual thermal responses with unprecedented precision and turn them into personalized health insights.
Postdoctoral positions available in #PMB Zhang Lab!
October 2025 - Director Colleen Clancy shared groundbreaking work on using digital twin technology to transform cardiovascular medicine. By combining computational modeling, AI, and multimodal biomedical data, her team is building personalized virtual replicas of the human heart.
