Today I share a visual abstract of one of the articles I like the most from our group, deciphering key immunopathological events in severe pandemic influenza. This was a colaboration with my former boss, Dr. David Kelvin, and it was published in Critical Care in 2010: doi: 10.1186/cc9259 #IDsky
In this visual abstract of our article in In IJID we highlight the importance of of combining innate immunity and endothelial dysfunction biomarkers to predict increases in the magnitude of organ failure in patients with infection and sepsis (10.1016/j.ijid.2024.107142)
Another visual abstract of a previous work from our group evidencing the benefit of implementing programms to detect sepsis in preventing mortality derived from nosocomial sepsis (J Hosp Infec DOI: 10.1016/j.jhin.2017.08.022) #IDsky #sepsis
Lymphopenia is mostly a consequence of migration to tissues and to some extent of apoptosis during severe pneumonia (in immunocompetent patients)
I share here the visual abstract of an important article from our group in colab with the groups of Dr Toni Torres (Hospital Clinic) and Rosario Menendez (Hosp La Fe) identifying Lymphopenic Community Acquired Pneumonia as a phenotype associated with mortality doi: 10.1016/j.ebiom.2017.09.023 #IDsky
This article from our group summarised the main immunological alterations in sepsis (Journal of Infection doi: 10.1016/j.jinf.2016.01.010) www.journalofinfection.com/article/S016...
A new summary of an old article from our group published in Journal of Infection (doi: 10.1016/j.jinf.2014.12.010) #sepsis #IDsky #infection
With the support of AI, I am starting to summarise some of our more important articles (summary 1: Quantification of Immune Dysregulation by Next-generation Polymerase Chain Reaction to Improve Sepsis Diagnosis in Surgical Patients", Annals of Surgery, DOI: 10.1097/SLA.0000000000002406)
In the pandemics, a mainstream theory proposed that in critical status, viral replication was over. Here we show that 60% of ventilated patients had replicative virus in the lungs, with 20% in high levels, mainly those with early resp. failure. #IDsky #COVID19
www.sciencedirect.com/science/arti...
Do critically ill COVID-19 patients still carry live virus in the lungs?
In our new study we show that patients who develop rapid respiratory failure still have replicating virus. Important finding for guiding antivirals in future pandemics #IDsky #COVID19
www.sciencedirect.com/science/arti...
💥🆕“Sepsis”.The Lancet Seminar
Our new article
👇Free Access
bit.ly/4aJIiKo
@unmc.bsky.social @unmc-id.bsky.social @unmccom.bsky.social @critcaremed.bsky.social @criticalcarereviews.com @thelancet.com @thelancetinfdis.bsky.social@lancetrespirmed.bsky.social#IDSky #MedSky #PCCSky #ICUSky #Ansky #EMSky
Enhorabuena por un trabajo bien hecho. Me parece que su labor y dedicación a los trabajadores será recordada en los libros, y desde luego, por la gente.
Infographic on Madrid study. For immunocompromised, need combination antivirals +/- monoclonal antibodies to get rid of persistent COVID infection in immunocompromised. Blue title. Red single drug box. Green combination box. Bottles of Remdesivir, Paxlovid, syringe of Sotrovimab. COVID virus breaks up with combo drugs.
In immunocompromised patients, persistent COVID often fails single-drug treatment.
Madrid study shows combination therapy (Remdesivir + Paxlovid ± Sotrovimab) clears infection and overcomes resistance. buff.ly/tqlmc0I
Personalized antiviral strategies matter.
#medsky #IDsky #publichealth #oncsky
A new paper from WHO-ISARIC that confirms lymphopenia as a marker of severity and poor prognosis in COVID-19, reinforcing our description of lymphopenic CAP (L-CAP) in 2017 In EbioMedine (I link our paper as a response to this one)
link.springer.com/article/10.1...
This paper identifies transcriptomic signatures associated to mortality in sepsis similar to those we found ten years ago: neutrophil dysregulation + adaptive immunity depression, and evidences the relevance of combining host and microbial info. academic.oup.com/ajrccm/artic...
Microbes Meet Host: The Next Frontier in Sepsis Classification
@atscommunity.bsky.social #medsky
🔓 Open Access
🔗 tinyurl.com/bdes2e5s
After more than eight years serving as coordinator of the European Group on Immunology of Sepsis (EGIS) along with Prof. Ignacio Rubio, it is time for me to step back. The steering committee has designed Dr. Martin Winkler as my sucessor. I am sure he will do an excellent job.
www.egis-online.eu
News are so terrible these days, that I need to concentrate in something constructive: let's do science, teach and cure people working together! In the world we are more people willing to improve things than those willing to destroy it...!
@biosepsis.bsky.social
Help raise awareness of the patient safety need for critical care clinical trial reform by forwarding this review.
pssjournal.biomedcentral.com/articles/10....
Excellent piece that explains why Denmark’s childhood vaccine schedule isn’t right for the United States.
Every major publication should run a piece like this.
@jakescottmd.bsky.social:
www.statnews.com/2025/12/19/d...
Terrible attacks against the Jewish community in Australia and against the University community in the USA this week. My sincere condolences to the victims and their families.
This (just published) paper confirms what we described in 2021: critically ill COVID-19 patients lacking of antibodies against the virus have poorer outcomes. I link the two papers below..
link.springer.com/article/10.1...
With 450 million people, some of the best Universities in the world, the more advanced democratic systems and the best social protection in the world, we should believe in our own future...we the European Union countries must stay together to keep on representing a model to the world! #EuropeanUnion
New vignette on our Editorial published in Intensive Care Medicine, written by Dr Jean-Marc Cavaillon, Dr Hjalmar Bouma and myself! #IDsky
link.springer.com/article/10.1...
A clinical decision tool including a decision tree, point-of-care testing of CRP, and safety-netting advice to guide antibiotic prescribing in acutely ill children in primary care in Belgium (ARON): a pragmatic, cluster-randomised, controlled trial
#IDSky
www.thelancet.com/journals/lan...
Our editorial on the clinical value and physiological meaning of HLA-DR in monocytes in septic shock is out. In this editorial we comment on an article from Dr. Monneret et al on a large cohort. It has been a honor to write it with Dr Cavaillon and Dr Bouma #IDsky
link.springer.com/article/10.1...
