🏛️ Congratulations to our researchers honored in the France 2030 frameworks PEPR MIE (led by ANRS MIE) & PEPR PREZODE!

🏅 PEPR MIE Flash Call:

Nadia Naffakh & Léonard Heyerdahl

🏅 PEPR MIE Junior Chairs:

Marine Petit & Thomas Vial

🏅 PEPR PREZODE:

Katherine Worsley‑Tonks

👉 anrs.fr/financements...

Silencing a key gene in this pathway (ahcy) enhanced the replication of dengue virus in mosquito cells.

🦠This revealed a new antiviral hub that could be targeted for vector control.

Huge thanks to the team, especially co-first @sumeyye-ozhan.bsky.social & our PI @merklinglab.bsky.social ! 🙏

We identified the larval stage as a potential metabolic hotspot! 🐛
The methionine cycle appears to be a central metabolic hub, suggesting a high capacity for methylation. 🧬

(We even profiled the larval food!)
#Metabolomics #Epigenetics

Stage-resolved metabolomics reveals the methionine cycle as a key regulator of Aedes aegypti development and dengue virus susceptibility Developmental transitions in the mosquito Aedes aegypti are central to vector competence and disease transmission, yet the underlying metabolic programs remain poorly defined. Here, we use untargeted ...

Kicking off the new year with mosquitoes, metabolomics, & arboviruses! 🥳

🦟Our new preprint is out! We mapped the metabolism of the Aedes aegypti mosquito across its life cycle to find new ways to fight dengue virus.

Check it out on: doi.org/10.64898/202...

#VectorBiology #Metabolomics #Mosquito

Single-cell transcriptional landscapes of Aedes aegypti midgut and fat body after a bloodmeal Aedes aegypti mosquitoes are vectors for numerous arboviruses that have an increasingly substantial global health burden. Following a bloodmeal, mosquitoes experience significant physiological changes...

🦟❓How do mosquitoes respond to a bloodmeal at the #SingleCell level ? Please have a look at pre-print biorxiv.org/content/10.1... and website aedes-cell-atlas.pasteur.cloud to find out and look at your favorite cells and genes ! #Aedesaegypti