Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration
This review highlights #Tcells as key regulators of #HairFollicleRegeneration, controlling #stemcell activity and immune balance, with disruptions leading to #alopecia, offering insights into immune-driven #HairDisorders and potential targets.
#OpenAccess: doi.org/10.1016/j.ge...
Before they were arrested- Vets are demanding an end to the war on Iran at the Cannon Building in Washington, D.C.
The EU now requires all Mobile Phones to be sold with easily replaceable and standardised batteries, as they used to be.
From 2027 they all will be again, in Europe.
Voting Reform is the equivalent of voting twice for Trump.
It is an act of pure ignorance, or racism, or both.
And, as we all know, it leads nowhere good.
Please god UK. Do not let that happen. Learn from our mistakes. Learn from America’s mistakes.
Just get your shit together.
Ok I’d like to share that I have finally begin writing a #paper on our #seasonal #microbiota data. #ovary maturation & a lot of #next-gen #sequencing. It is exiting & scary & frustrating & exhilarating. I love it. Every little bit of it: I love ❤️ it. #Academicblueacky #science.
It is truly unbelievable & disheartening that after the last 10 years of local and international political discourse, people are still making their decisions this way. 🙁
When using Microsoft Word or Google Docs, don't just make text bigger and bolder to make it a heading. That will work for sighted users, but screen reader users will miss that and just hear it as normal paragraph text. Use actual heading styles, like level 1 through 6.
Vitamin A deficiency suppresses CEACAM1 to impair colonic epithelial barrier function via downregulating microbial-derived short-chain fatty acids
#VitaminADeficiency from #pregnancy reduces #SCFA-producing #GutMicrobes, lowering SCFA levels and suppressing colonic CEACAM1, impairing epithelial integrity; timely postnatal VA supplementation restores SCFAs, and protects colonic barrier function.
Read: doi.org/10.1016/j.ge...
This is a special one - very excited to finally share our work exploring how microbes affect circadian clocks! Thank you to all our collaborators and the #circadian field for being so welcoming and full of incredible science! Hope to see you all at #SRBR
www.biorxiv.org/content/10.6...
Stratified LD Score Regression shows that alleles affecting blood-immune-inflammatory and cardio-metabolic traits were unusually affected by selection, and that selection intensity increased in the Bronze Age
Ancient DNA reveals pervasive directional selection across West Eurasia🏺🧪
www.nature.com/articles/s41...
Estimates selection coefficients at 9.7 million variants, enabling study of how Darwinian forces couple to allelic effects and shape the genetic architecture of complex traits.
France passed a law requiring solar panels on every parking lot with more than 80 spaces.
Equals 10 nuclear reactors
Reduces heat island, shades cars
The US -- 800 million parking spaces. Most of them are uncovered asphalt sitting in direct sunlight.
Why aren't we doing this?
🪱 Serving head-to-tail fluorescence 💅 Whole-animal FISH in the planaria Schmidtea mediterranea: 🔵 Head 🟣 Gut 🟡 Tail ✨ Masters of regeneration and color coordination 📸 Image from Viraj Doddihal #FluorescenceFriday
To be featured submit your images here ➡️ forms.gle/PWyaViekkNNn...
Evolutionary dynamics of temporal transcription factor series in the insect optic lobe www.biorxiv.org/content/10.64898/2026.01...
Overview of RB-TnSeq screens. Top left: Schematic for RB-TnSeq screen experimental set-up. Top middle: Pie chart depicting the number of RB-TnSeq screens completed for each category. Top right: Previously published TnSeq fitness with 27ng/mL isoniazid plotted against BarSeq fitness with 25 ng/mL isoniazid. Dotted line represents linear correlation between statistically significant hits from RB-TnSeq with TnSeq. Bottom left: BarSeq fitness (log2 fold change) for sugI (Rv3331) and sugA (Rv1236). Bottom right: Cofitness data for Rv3220c and Rv1626.
Discovery of gene functions in #Mycobacterium #tuberculosis has been slow. This study tests a genome-wide barcoded #transposon library across 95 environmental conditions, providing a rich resource of new gene functions, including metabolic & resistance pathways @plosbiology.org 🧪 plos.io/4vG0mz1
Félix Simon's paper is out in its final form 😍
When we got into (extreme) detail in the temporal and spatial patterning of neuroblasts, Félix asked a simple question "sure, but how does this translate into neuronal cell fate?". www.nature.com/articles/s41...
Reform and right-wing media present the party's claims – that the 'Boriswave' will cost us each £20k – as an objective fact.
I spoke to economists and experts who said the "fantasy" analysis was "wildly off".
Me for @bylinetimes.bsky.social
bylinetimes.com/2026/04/16/e...
Nigel Farage has said that he wants to move towards an insurance based healthcare system.
The NHS wasn’t built in Wales just to be a destroyed by Reform UK.
A vote for Plaid Cymru is a vote to protect and strengthen our NHS.
Hey just recently set up a #youtube channel for the lab @EEL-2026 #Evolutionary #Epigenetics Laboratory.
Brexit is an unpopular shitshow, global politics and priorities have changed and there’s now a majority of voters who’ve been resolutely scorned since the Brexit vote.
I dunno. Maybe tap into that demographic and see how you go. Or keep losing to Reform.
www.theguardian.com/commentisfre...
Directed coupling patterns between infraslow brain hemodynamics, electrical, and water fluctuations.
Sleep alters neurovascular and hydrodynamic coupling in the human brain🏺🧪
www.pnas.org/doi/10.1073/...
These multimodal findings highlight a fundamental change in coupling dependent on brain state, suggesting that both neural and nonneural alteration contribute to sleep-related brain function.
“Not only is Reform taking large amounts of money from an industry with a big interest in changing UK Govt policy, but that industry is also one with major links to organised crime, terrorism and foreign dictatorships.”
The corrupt stink of Reform is overwhelming.
open.substack.com/pub/adambien...
GRAMD1C-mediated cholesterol transport is critical for viral replication. Top: Schematic of cholesterol transport by the GRAMD1C ASTER domain from PM to ER. Bottom: Confocal fluorescence microscopy analysis of the co-localization of TGEV dsRNA (indicated in magenta), ectopic expression of GRAMD1C-HA (indicated in green), and ER-tracker pDsRed2 (indicated in red) in WT cells mock-infected or infected with TGEV (MOI = 0.1), at 12 hpi. Scale bars, 10 µm.
#Coronaviruses remodel host membranes for replication, but which pathways are involved? This study reveals #cholesterol transporter GRAMD1C as a host factor that promotes replication organelle formation and supports replication across multiple coronaviruses @plosbiology.org 🧪https://plos.io/3NQ4FGY
Five large chromosomal inversions contribute to the diversification of Malawi cichlids. Inversions established in the diverse benthic subradiation. Inversion-region haplotypes were exchanged through hybridization of lineages within and outside of the Malawi radiation and contribute to ecological and habitat divergence, sensory adaptation, and sex determination.
Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid radiation 🧪
www.science.org/doi/10.1126/...
Found multiple segregating inversions in these populations, and genomic signatures that these regions had been used repeatedly in adaptation throughout these species.
If you know a graduating undergraduate looking for the chance to spend 1-2 years in a lab before graduate school, we're hiring! Our lab explores morphogenesis, defining how the cell adhesion & cytoskeletal machinery work together to allow cells to change shape & move tarheels.live/peiferlab/ 1/n RT
🧬 Sea Lamprey (Petromyzon marinus) ✨ A window into early vertebrate evolution! 🧠 Lampreys help reveal how key vertebrate features, like neural crest cells, the vertebrate brain, and craniofacial structures originated and diversified 📸 Image by David Jandzik #ModelMonday #DevBio #EvoDevo #Lamprey
Ageing‑related gene signatures in #HFpEF reveal immune/metabolic dysregulation; AGTR1a, NR3C1, and PRKAB1 show strong diagnostic potential, while #MachineLearning and ageing scores highlight subtype‑specific immune infiltration and biomarker value.
Read: doi.org/10.1016/j.ge...
Issue 6 is now complete!
On the cover: Fluorescence micrograph of a Caenorhabditis elegans gonadal region showing the spermatheca (cyan) and adjacent syncytial gonad (magenta). For more details, see Chan et al.
journals.biologists.com/dev/article/...
90% of doing science is being open to new ideas.
Every scientist is a bit of an artist
and every artist is a bit of a scientist
