picture credit: Dr.Torsten Seemann (11 years ago!)
🧵 The Myth of Push-Button Bioinformatics
1/ Some think bioinformatics is just pressing a button:
🔘 RNA-seq Analysis
🔘 Make Fancy Figures
🔘 Submit to GenBank
If only it were that easy... but reality is very different.
From fate to form: the journey to whole-embryo spatial transcriptomics
In this 'Behind the paper' feature, @yinanwan.bsky.social shares the inside story of an ambitious journey with @schierlab.bsky.social & co.
thenode.biologists.com/from-fate-to...
#SpatialTranscriptomics #CellSegmentation
FastReseg
github.com/Nanostring-B...
Using transcript scoring +"spatial doublet" test to rectify segmentation errors🥸
vs transcript-dominant approaches: Baysor Proseg
#SciReports 2025
www.nature.com/articles/s41...
Jeff Bezos, one of the richest men on earth, is raising $100 billion to replace workers with robots around the world.
The oligarchs want it all. Not going to happen.
Stand up and FIGHT BACK.
Spectral multiplexing is typically limited to 4-5 channels. Our new preprint introduces a framework that utilizes DNA barcoding and signal tuning to enable robust spectral unmixing and ground-truth benchmarking to achieve 15-plex subcellular profiling without cycling
www.biorxiv.org/content/10.6...
Aristaless-Like homeoboX 1 as a transcriptional determinant of extraocular muscle progenitor
Global KO🐭
Mesp1+ cranial mesoderm KO🐭
Wnt1+ cranial neural crest KO🐭
ALX1 is a causal gene of👤Frontonasal dysplasia-3
@paul-iyyanar.bsky.social #DisModelMech 2026
journals.biologists.com/dmm/article/...
Ep 27- have you heard deep learning called a "black box"? It often is, but this week, @erinweisbart.bsky.social tells @bethcimini.bsky.social about a cool paper from the @assafzaritsky.bsky.social team (and Erin!) using DL to make Cell Painting even more powerful, but still interpretable. So fun!
ICYMI: New Online! Neural crest gene regulatory networks as drivers of development, diversification and disease
1/ 🧵 In our new paper, we show that JARID2 and PALI1 mimic H3K27me3 to antagonise PRC2. www.cell.com/molecular-ce...
We're excited to announce that registration for our upcoming Spatial Omics workshop has opened!
Details in 🧵
A Visual Guide to DNA Sequencing.
Learn how different DNA sequencing technologies work, from Sanger sequencing to Illumina to nanopores. (Complete with illustrations!)
Written by Evan DeTurk. Illustrated by Ella Watkins-Dulaney.
🚨Next DevBioConnect on the way
Developmental Biology Author webinar featuring Dr. Diana L. Carlone & Dr. Emil Kriukov 📷
🗓️Mar. 10th, 2026
⏰11 am–12 pm CST
docs.google.com/forms/d/e/1F...
@socdevbio.bsky.social
www.sdbonline.org/meeting?Reso...
Development presents... Wednesday 25 February – 15:00 GMT/UTC Chair: Polina Kameneva Joaquín Navajas Acedo (University of Basel) ‘Spatiotemporal emergence of somatosensory neuron diversity’ Carlo Donato Caiaffa (Universidade de São Paulo) ‘Decoding the role of HNRNPH2 in neural development using brain organoids and antisense oligonucleotides’ Clarisse Brunet (Institut Curie) ‘Decoding the gliogenic switch: how human brain organoids reveal the secrets of glial cell fate’ #DevPres @dev-journal.bsky.social theNode.biologists.com/devpres The Company of Biologists logo Development logo QR code
📢Register for our #DevPres webinar on neurodevelopment
The webinar, chaired by Polina Kameneva, features talks from Joaquín Navajas Acedo @mads100tist.bsky.social, Carlo Donato Caiaffa & Clarisse Brunet @clarissebrunet.bsky.social.
🗓️25 February, 15:00 GMT/UTC
us02web.zoom.us/webinar/regi...
The $100 whole human genome sequence finally reached!
www.sandiegouniontribune.com/2026/02/19/s...
We are very happy to see our study finally appear online @nature.com! This has been work of nearly 10 years in collaboration with the National Institute of Genome Medicine 🇲🇽, the National Cancer Institute 🇲🇽, the @sangerinstitute.bsky.social and others ⬇️
www.nature.com/articles/s41...
🧵 10 free bioinformatics tools you should know in 2026. These will save you time, money, and headaches.
anndataR: converting single-cell data, from R to python and back tomsing1.github.io/blog/posts/a... #Rstats
Demystifying Oral Epithelial Dysplasia: a histological guide
Enhanced interpretation of WHO 28 features
Normal oral mucosa variants
Core architectural & cytologic abnormalities
#Pathology 2024
www.pathologyjournal.rcpa.edu.au/article/S003...
Mosaic partial epidermal reprogramming remodels neighbors and niches to refine skin homeostasis and repair @natcomms.nature.com
www.nature.com/articles/s41...
New paper out today, 'Global North-South science inequalities due to language and funding barriers'
We highlight how language and funding barriers can compound inequity and offer practical recommendations to bridge these gaps.
Read the Open Access paper here! 👉 tinyurl.com/654ztk3w
Neural crest contribution to craniofacial structures and phenotypic variation
#DBfeature
Bones, brains, and bias—neural crest cell contribution to craniofacial structure
Active Learning Assignments for craniofacial perception & normal phenotypic variation
by Jeffrey Carmichael, Diane Darland et al
www.sciencedirect.com/science/arti...
Figure 2 The dimensions of cancer CREDIT Hanahan - Cell.
An update to the Hallmarks of Cancer framework for understanding (and researching) what causes human cancers. spkl.io/63321Aqwbc
Douglas Hanahan
@cp-cell.bsky.social
Review @natprot.nature.com @garybader.bsky.social
Tutorial: annotation of animal genomes
www.nature.com/articles/s41...
EGFR signaling in the tissue around oral cancers increases nerve sensitivity and impairs opioid efficacy
www.science.org/doi/10.1126/...
This review reflects on a journey I’ve been lucky to witness closely:
◼️ The transformation of single-cell proteomics from a fragile idea into a powerful discipline.
The technological progress towards deeper coverage and higher throughput is fast and exciting, but what excites me most is ...
1/n
🚨Next DevBioConnect on the way‼️
Developmental Biology Author webinar
by Dr. Alexa Burger & Dr. Robert Huebner
🗓️ Feb 10th, 2026
⏰ 11 am–12 pm CST
To Register
forms.gle/4J192L42y6sg...
@socdevbio.bsky.social
@aburger2009.bsky.social
#SpatialTranscriptomics
Visium
+ scRNAseq
Oral Squamous Cell Carcinoma
vs paired Oral Leukoplakia vs normal tissues
Inhibin A+ monocyte enriched in premalignant OLK lesions
1⃣Mesenchymal CAF 2⃣APOE+NRG1+ Mφ 3⃣TNFRSF4+ Treg ⬆️with tumor progression
#CellDiscov 2023
www.nature.com/articles/s41...
Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...
Peer Bork died yesterday 💔 which shocked me. In 2003 I did a short-term fellowship in Peer’s lab because I idolized him. I met Martin there & we wrote this paper together. Peer was great at bringing people together; a master collaborator with a rare ability to think up big ideas.
Non-negative matrix factorization is a commonly used technique in genomics data analysis.
Read my tutorial on how you can use it for single-cell RNAseq data divingintogeneticsandgenomics.com/post/matrix...
