Spike Lee at the Knicks game at MSG.

#spikelee #popeleo #knicks #madisonsquaregarden

A new review is online!

Philipp Henneke, Sebastian Baasch and co-authors @uni-freiburg.de tell you all about how #cytomegalovirus manipulates myeloid cells to invade tissues.

-> link.springer.com/article/10.1...

Clinical progress of engineered cellular immunotherapies for autoimmunity - Nature Biotechnology Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies.

Engineered cellular immunotherapy shows great potential for treating autoimmune diseases. Payne and colleagues review emerging clinical data of the most recently developed technologies go.nature.com/4cvxe67
rdcu.be/feuuv

Pathophysiological roles of monocytes and macrophages in cancer - Nature Reviews Immunology Monocytes and macrophages adopt modular programmes in response to cancer cells, which can be viewed as an ‘infectious self’ challenge, and cues from the surrounding tissue environment as well as organ...

Even though they may have originated as part of the host defense. In the context of cancer, #macrophages mostly adapt tumor supportive roles, especially in advanced #cancer.

Pathophysiological roles of monocytes and macrophages in cancer | @natrevimmunol.nature.com

www.nature.com/articles/s41...

Microbiome signature of Parkinson’s disease in healthy and genetically at-risk individuals - Nature Medicine Microbiome analysis suggests that gut microbial changes in Parkinson’s disease evolve progressively from healthy individuals to genetically at-risk individuals to clinically affected patients, with th...

We've known the gut-brain axis is a key underpinning of Parkinson's disease. Today, for the 1st time, a gut microbiome signature denoting risk found in healthy individuals with genetic predisposition

nature.com/articles/s41...

81. Jahrestag der Befreiung des KZ Buchenwald YouTube video by Buchenwald and Mittelbau-Dora Memorial Foundation

Die 𝐆𝐀𝐍𝐙𝐄 Rede von Hape Kerkeling in Buchenwald (und nicht nur der eine Satz, der jetzt überall zitiert wird) ist hörenswert und ein 𝐚𝐛𝐬𝐨𝐥𝐮𝐭𝐞𝐫 𝐌𝐞𝐢𝐥𝐞𝐧𝐬𝐭𝐞𝐢𝐧 der Erinnerungskultur in Deutschland!

Bitte nehmt euch die 10 Minuten Zeit, um euch das zu Gemüte zu führen.

www.youtube.com/watch?v=e_Ps...

⬇️

Important work on the role of #interferon in perinatal immunity by @lmu.de scientists within the PILOT #SFB by @dfg.de

Human neonatal CITE-seq atlas identifies an immune transition at 32 weeks' gestation from CD15+ myeloid-dominated to interferon-primed immunity

www.biorxiv.org/content/10.6...

Christopher Penn wrote: Just remember that given the abundance of neurodivergent people in science, it's far more likely that autism causes vaccines.

A different perspective.
Always helpful.

The exposome of brain aging across 34 countries - Nature Medicine Exposome analyses across 34 countries showed that social exposures were associated with faster functional brain aging and physical exposures with faster structural brain aging.

www.nature.com/articles/s41...

This

This 💯

Codeberg.org Codeberg is a non-profit community-led organization that aims to help free and open source projects prosper by giving them a safe and friendly home.

Moving everything to codeberg.org almost done. Only my static website pipeline needs a bit tweaking (markdown, actions, deployment, custom domain etc).

Bye bye Github! 👋

#migratetocodeberg #codeberg #exitgithub

Diet–microbiome associations in 10,068 individuals from the Human Phenotype Project to guide personalized nutrition - Nature Medicine Analyses of more than 10,000 participants from the Human Phenotype Project revealed distinct, persistent food–microbiome associations that can be used to simulate personalized dietary interventions to...

#NatMicroPicks

Diet-microbiome analysis at population scale 💻🦠

Diet shaped gut microbiome composition and function analysed at species-level resolution might enabling long‑term predictions and personalized dietary intervention strategies.

#MicroSky #MicrobiomeSky

www.nature.com/articles/s41...

A transcriptomic microglia taxonomy across mouse and human pathologies @natimmunol.nature.com
www.nature.com/articles/s41...

Fibroblasts underpin immune-competent niches in the healthy and diseased CNS. Schematic representation of the topological organization of fibroblasts along the vascular tree and across meningeal and brain parenchymal compartments in the context of (A, B) homeostasis, (C, D) infection, (E) autoimmunity, and (F) sterile tissue injury. The provision of cytokines, chemokines, survival factors, and ECM components by local fibroblasts are indicated in each condition. The legend of depicted cell types and vasculature is provided. (A) In the homeostatic CNS, fibroblastic cells include mural cells, perivascular fibroblasts situated abluminal to mural cells, and meningeal fibroblasts. (B) In the steady-state condition, PDPN+ FRC-like cells are limited to DALTs positioned at the intersect of rostral-rhinal, olfactory, and superior sagittal sinuses. In (C) chronic dural infection and (E) autoimmunity, persistent inflammation is associated with TLS formation. TLS are underpinned by FRC-like cells and FDCs providing T and B cell chemoattractants, survival factors, and canonical markers of FRCs. (D) In infections of the brain parenchyma, similar chemokines and FRC markers are upregulated in the absence of TLS formation. (E) In the context of deep gray matter injury, perivascular fibroblasts of the Virchow-Robin space constitute a major source of scar-forming cells. In addition to profuse ECM deposition, scar-forming fibroblasts secrete myeloid cell survival factors and chemokines to drive early and late phase scarring, respectively.

🤩 new review on CNS perivascular fibroblasts interactions in injury, disease & neuroimmunity - from Natalia Barbara Pikor group @ethz.ch led by Margaux Océane Verdon - check it out!
academic.oup.com/jimmunol/art...

Skull bone marrow immunity in brain health and disease: mechanisms and models Abstract. The skull bone marrow (sBM) is a hematopoietic site intimately connected to the dura mater—the outermost layer of the meninges that surround the

Hot off the press from @jonykipnis.bsky.social and Justin Rustenhoven on skull bone marrow immunity

Skull bone marrow immunity in brain health and disease: mechanisms and models | JI

academic.oup.com/jimmunol/art...

Principles of resident tissue macrophages revealed by the eye Macrophages are no longer viewed as transient immune passersby but as integral tissue components that regulate physiological homeostasis. Many residen…

Cool new Tissue resident #macrophage demonstrated using the eye ecosystem as a model by Danny Saban and colleagues. Here is an insightful tutorial: x.com/sabanlab/sta...

Principles of resident tissue macrophages revealed by the eye

www.sciencedirect.com/science/chap...

Cell Press Symposia

Check out the #CellPressEvents #CPSsinglecellbiology2026 speaker lineup, reflecting the breadth of expertise advancing the field, from multi-omics to AI-driven analysis.
@helmholtzmunich.bsky.social @ethz.ch.bsky.social
http://dlvr.it/TRbpj6

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation - Nature Immunology Prinz and colleagues examine the distinct functions and repopulation properties of leptomeningeal and perivascular macrophages that mediate immune responses at brain boundaries.

New insights on brain macrophage repopulation by the Prinz group:

Distinct origins and niches determine the cellular responsiveness of CNS macrophages after repopulation | @natimmunol.nature.com

www.nature.com/articles/s41...

Transposable elements, such as retrotransposons and endogenous retroviruses, are increasingly recognized for their important roles in genome function and impact on disease development go.nature.com/4tQ1zTn
rdcu.be/e8Eci

New insights into the #spatial patterns of IDH mutant gliomas by Rouven Hoefflin from the Tirosh Lab

www.biorxiv.org/content/10.6...

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties Microglia arise from yolk sac progenitors and are thought to persist throughout life with minimal input from adult hematopoiesis. However, whether bra…

Brain-engrafted monocyte-derived macrophages from blood and skull-bone marrow exhibit distinct properties - Neuron @cellpress.bsky.social

www.sciencedirect.com/science/arti...

Resident tissue macrophages maintain intraocular pressure homeostasis Intraocular pressure (IOP) is dysregulated in glaucoma, a leading cause of blindness. Immune contributions to IOP maintenance are poorly understood. Liu et al. reveal that long-lived resident tissue m...

Impressive work on the function of fetal macrophages in the eye by the Saban Lab

Resident tissue macrophages maintain intraocular pressure homeostasis: @cp-immunity.bsky.social

www.cell.com/immunity/abs...

Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease Nieto et al. profile cerebrospinal fluid cells in leptomeningeal disease across tumor entities and compare them with blood and tissue lesions using single-cell and spatial approaches, showing that the...

Integrative CSF profiling identifies disease-specific immune responses in leptomeningeal disease: Cell Reports Medicine

www.cell.com/cell-reports...

In imaging-based spatial transcriptomics (Xenium CosMx), 40% RNAs are Not assigned to segmented cells

This amazing preprint @fabiantheis.bsky.social studies the origin, heterogeneity & biological inference (Modeling cell protrusion/contacts😎) of unassigned RNAs

www.biorxiv.org/content/10.6...

Beautiful new color palette #dataScience

Love this analysis

A promotional graphic for an EMBO Workshop titled "Brain (epi)genome," scheduled for 21-24 April 2026 at EMBL Heidelberg and virtually. The background features colorful illustrations of brain cells and synapses. Logos for EMBO and EMBL are displayed at the bottom.

How does the (epi)genome generate the brain’s huge diversity of cell types? This @‌events.embl.org workshop brings together leaders in genomics, neuroscience, and epigenetics to explore the mechanisms shaping neural identity, connectivity, memory, and disease.

🔗 plos.io/4aJ9IS2

#EMBOBrainEpi

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...