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Posts by Alex Mackintosh

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When South Meets North: A Joint Contact Zone Coinciding With Environmental Gradients in Three Boreal Tree Species Post-glacial recolonisation of Fennoscandia created secondary contact zones in many species, offering opportunities to study how gene flow and selection contribute to their establishment and maintena....

The first chapter of my PhD thesis is out: doi.org/10.1111/mec.... !!!

This comparative study explores the presence and maintenance of a joint contact zone among three important forest tree species (formed during recolonisation after the LGM). Trees, genetics and evolution, just a perfect combo!

5 days ago 9 3 3 0

Computing coalescence rates for complex demographies and sampling configurations www.biorxiv.org/content/10.64898/2026.04...

1 week ago 2 1 0 1

PREPRINT ALERT!
Determinants of chromosomal rearrangements in holocentric Leptidea butterflies
www.biorxiv.org/content/10.6...

Massive #chromosome reshuffling in Leptidea #butterflies reveals how satellite DNA, rDNA, and duplications—not #transposons, shape the architecture of #genomeevolution.

4 weeks ago 8 4 0 0

diempy: fast and reference-free genome polarisation www.biorxiv.org/content/10.64898/2026.02...

2 months ago 2 4 0 0

The genetic architecture of local adaptation is historically contingent www.biorxiv.org/content/10.64898/2026.02...

2 months ago 3 4 0 1
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Genomic analyses in Drosophila do not support the classic allopatric model of speciation Abstract. The allopatric model of speciation has dominated our understanding of speciation biology and biogeography since the Modern Synthesis. It is uncon

New paper out: “allopatric” Drosophila species aren’t so allopatric after all. We show that most currently allopatric species pairs probably overlapped in the past and exchanged genes at levels similar to sympatric pairs. @evolletters.bsky.social

doi.org/10.1093/evle... [1/6]

3 months ago 57 26 1 0
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DDLS Research School Postdoc call 2026 Call for Academic and Industrial Postdoctoral Fellowships in Data-Driven Life Science 2026 Generic Description of the DDLS Postdoc Program The SciLifeLab and Wallenberg National Program for Data-Drive...

Hit me up if you'd like to apply to a Data-driven postdoc fellowship with me in Sweden. 2 year salary, excellent community. Deadline March 31. I have a project idea on reference bias vs pangenome, but keen on hearing ideas. Please share broadly.

www.scilifelab.se/data-driven/...

3 months ago 14 22 0 0
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Nucleotide diversity is a poor predictor of short-term adaptive potential A capacity to adapt is essential for a population to avoid extinction in a changing world and is recognised as a global conservation priority. Adaptation requires additive (heritable) genetic variatio...

I'm excited to share that our preprint is now available on bioRxiv! Our study challenges the widespread use of molecular genetic diversity as a predictor adaptive potential, with important implications for how genetic data is used to inform conservation decisions.

www.biorxiv.org/content/10.6...

3 months ago 54 30 0 2
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Congratulations to the winners of the 2025 Genomic History Inference Strategies Tournament challenges!

Among the 9 challenges, we had five winners: @alwaysrong.bsky.social, @adaigle.bsky.social, @andrewhvaughn.bsky.social, @thymelicus.bsky.social, @rgollnisch.bsky.social

4 months ago 20 10 2 0
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Robustness of Ancestral Recombination Graph Inference Tools to Phasing Errors Ancestral Recombination Graphs (ARGs) are fundamental population genetic structures that encode the genealogical history of a sample of haplotypes along the genome. They have recently received substan...

We are excited to share our recent work on the surprising robustness of Ancestral Recombination Graph (ARG) inference tools to computational phasing errors, now available on BioRxiv: biorxiv.org/content/10.1....
This work is co-advised by @yundeng.bsky.social and Rasmus Nielsen.
1/7

4 months ago 54 24 2 1
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Very happy to announce that the next POPGROUP meeting will take place in Lille on 7-9 January !

Follow ‪@popgroup2026.bsky.social for all updates.

📢 Please share widely ! 📢‬

6 months ago 13 11 0 0

You went to preschool with Naoyuki Takahata?!

7 months ago 3 0 1 0

HiC. Not particularly cheap, but it is probably the only (non-trio) method where you can accurately phase SNPs across a whole chromosome.

7 months ago 0 0 1 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

🚨New paper out in PNAS🚨

Soil eDNA reflects regionally dominant species rather than local composition of tropical tree communities 🧬🌿🌳🌺🧬

We asked about the spatial scale of biodiversity captured by samples of DNA from tropical soils #Luquillo #eDNA. A short 🧵....

www.pnas.org/doi/10.1073/...

8 months ago 36 13 2 1

A model-free method for genealogical inference without phasing and its application for topology weighting www.biorxiv.org/content/10.1101/2025.07....

8 months ago 4 5 0 0

Our new work on estimation of background selection (BGS) is up on bioRxiv.

We investigated the problem using simulations and also developed a method for joint inference of BGS, demography and partial selfing from windowed site frequency spectra along the genome.

Feedback is welcome. #BGS

9 months ago 1 3 0 0

Our new work on estimation of background selection (BGS) is up on bioRxiv.

We investigated the problem using simulations and also developed a method for joint inference of BGS, demography and partial selfing from windowed site frequency spectra along the genome.

Feedback is welcome. #BGS

9 months ago 1 3 0 0
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#PopGen New preprint of the team on the discovery of a very high rate of polymorphic duplication in a marine bivalve.

Imagine looking at the distribution of the allelic coverage fraction at heterozygous calls in an indivdual and getting this distribution 👇 😱😱😱

9 months ago 28 8 2 0
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Genomic regions of current low hybridisation mark long-term barriers to gene flow in scarce swallowtail butterflies Author summary Efforts to understand how new species evolve typically approach the problem through either: 1) investigating patterns of genetic exchange across ‘hybrid zones’ — where closely related s...

Speciation genomics in scarce swallowtails Iphiclides podalirius and I . feisthamelii : dx.plos.org/10.1371/jour...

11 months ago 11 5 0 0
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The 229 chromosomes of the Atlas blue butterfly reveal rules constraining chromosome evolution in Lepidoptera www.biorxiv.org/content/10.1101/2025.03....

1 year ago 15 5 0 1

Likelihoods for a general class of ARGs under the SMC www.biorxiv.org/content/10.1101/2025.02....

1 year ago 11 8 0 0
https://coursesandconferences.wellcomeconnectingscience.org/event/k-mer-workshop-for-biodiversity-genomics-20250601/

https://coursesandconferences.wellcomeconnectingscience.org/event/k-mer-workshop-for-biodiversity-genomics-20250601/

🚨Registration open🚨 1st - 6th of June, me, Katie Jenike, @rayanchikhi.bsky.social and Gene Myers will run a week long workshop on k-mers for biodiversity genomics organised by @connectingscience.bsky.social at @sangerinstitute.bsky.social. Join us & get equipped to wrestle large genomic datasets!

1 year ago 26 17 1 1

The test requires just one unphased diploid from each population and makes few assumptions about the underlying demographic history. I hope that others find the paper/method useful. 2/2

1 year ago 6 2 1 0
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Genealogical asymmetry under the isolation with migration model and a two-taxon test for gene flow Abstract. Methods for detecting gene flow between populations often rely on asymmetry in the average length of particular genealogical branches, with the A

My and Derek Setter's work on gene flow is now published in the latest issue of Genetics. We show that it is possible to detect past gene flow between two populations by summarising the asymmetry in pop-specific external branch lengths. 1/2
tinyurl.com/5ff8ch9e

1 year ago 62 34 1 0

Sadly I am no longer working on butterfly genomics. I am currently focused on popgen methods with application to plant genomes (mostly simulated plant genomes for now...) Perhaps I'll return one day 🦋

1 year ago 3 0 0 0
Aricia species photos

Aricia species photos

A new case of hybrid speciation? www.biorxiv.org/content/10.1...

1 year ago 13 6 1 0
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