International Day for the Elimination of Violence against Women | United Nations The International Day for the Elimination of Violence against Women aims to create awareness of the fact that violence against women is a human rights violation that impedes progress in many areas, in...

Today is the International day for the elimination of violence against women. In 2024, an estimated 50,000 women and girls were killed by intimate partners or family members worldwide. That is 137 women and girls every day. One every ten minutes. www.un.org/en/observanc...

The E3 ubiquitin ligase complex SIFI has a role in terminating stress response signalling, to restore cellular homeostasis. Researchers @nature present the cryo-EM structure of this ~1.3 MDa complex providing insights into its mechanism of action. www.nature.com/articles/s41...

O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells - Nature Communications O-GlcNAcylation can regulate protein properties and functions. Here, the authors systematically study its impacts on protein solubility and biocondensate formation. O-GlcNAc dramatically reduces prote...

O-GlcNAcylation reduces proteome solubility and regulates the formation of biomolecular condensates in human cells #NatCommun #MassSpec www.nature.com/articles/s41...

Associate or Senior Editor (Organic Chemistry), Nature Communications Job Title: Associate or Senior Editor (Organic Chemistry), Nature Communications Organisation: Nature Portfolio Locations: Jersey City, London, New York, Philadelphia or Washington DC - hybrid working...

Nature Communications is looking to hire an organic chemist – more details in the link below #Chemsky #Chemjobs 🧪

Structural basis for the ubiquitin chain recognition of the human 26S proteasome Proteasomal degradation is a fundamental process for all eukaryotic life. A protein destined for degradation is first tagged with a polyubiquitin chain, which is selected by the proteasome. Different ...

New Preprint: We have solved the structure of the proteasome in complex with two different ubiquitin chains: www.biorxiv.org/content/10.1... This work is spearheaded by PhD Student Sascha Amann
Let me walk you through it 🧵 1/9

Enhanced sensitivity and scalability with a Chip-Tip workflow enables deep single-cell proteomics - Nature Methods Chip-Tip is a label-free quantification-based single-cell proteomics workflow for deep single-cell proteomics, which identifies over 5,000 proteins and 40,000 peptides in single HeLa cells.

🚨 Our #singlecell article is out! We describe the Chip-Tip label-free SCP workflow quantifying >5000 proteins in single HeLa cells. With high scalability, increased depth and throughput we can now envision large-scale LFQ-SCP biomedical studies!
www.nature.com/articles/s41...

Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5

ATG8ylation of vacuolar membrane protects plants against cell wall damage - Nature Plants ATG8ylation of the tonoplast, triggered by cell wall damage, acts as a vital vacuolar quality control mechanism that safeguards vacuolar integrity and ensures cell survival under stress.

🌱 Thrilled to share that our latest research on Vacuolar Quality Control is now published in Nature Plants! 🚀 We uncovered a new mechanism of ATG8ylation of the tonoplast, which helps us understand how cells survive to cell wall damage.
Check it out here: www.nature.com/articles/s41...

Hold this date for the 2nd UK Proteostasis Network in Dundee👉🏾 3-5 June 2025. This will be a joint meeting with the UK Autophagy network. More info coming soon proteostasisuk.co.uk/conference-2...
@ukproteostasis.bsky.social

C-terminal amides mark proteins for degradation via SCF–FBXO31 - Nature SCF–FBXO31 scans proteins for C-terminal amidation and marks them for subsequent proteasomal degradation.

How do cells recognise disease- and stress-affected proteins for clearance by ubiquitination? Work @nature shows that such proteins are marked with C-terminal amides, allowing their targeting by SCF/FBXO31 ubiquitin ligase for degradation. shorturl.at/B3rmR
& NV
shorturl.at/fImjA

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control - Nature Communications LC-MS-based proteomics often relies on data-dependent acquisition (DDA) for quality control. Here, the authors demonstrate that data-independent acquisition (DIA) outperforms DDA in detecting subtle c...

iDIA-QC: AI-empowered data-independent acquisition mass spectrometry-based quality control #NatCommun www.nature.com/articles/s41...

A majority of eukaryotic proteins are N-terminally acetylated. Here is an updated review of the responsible enzymes and the impact of this modification for proteins, cells and organisms @naturecomms.bsky.social @ispt-proteinterm.bsky.social #acetylation #N-termini #N-degron rdcu.be/d6mbd

Tell me they are growing up with cats without telling me that they are growing up with cats…

Image credit: Togna Zambogna

Our call for papers with @naturecomms.bsky.social, Communications Chemistry & Scientific Reports welcomes manuscripts exploring glycans in the broadest sense, seeking basic, translational, and applied glycobiology research:
www.nature.com/collections/... 🧪

MPicker: visualizing and picking membrane proteins for cryo-electron tomography - Nature Communications Visualization and picking of membrane proteins in cryoET tomogram is often challenging. Here, the authors developed a software MPicker based on membrane flattening to simplify the visualization, picki...

Paper of interest for the #CryoET folks.

www.nature.com/articles/s41...

E2–Ub-R74G strategy reveals E2-specific ubiquitin conjugation profiles in live cells - Nature Chemical Biology Shen and Yin developed a technology named FUSEP to profile the E2-specific ubiquitome that makes use of a fusion between E2 and ubiquitin carrying a R74G point mutation, which leaves an LGGG remnant f...

A new tool FUSEP profiles the E2-specific ubiquitome and enables systematic studies of non-lysine ubiquitin conjugation, here used to identify the existence of tyrosine ubiquitination

www.nature.com/articles/s41...