Study Links Chronic Sickle Cell Pain to Gut Microbial Imbalance Dr. Katelyn Sadler and a team of fellow UT Dallas researchers found a clear connection between the chronic pain experienced by some people with sickle cell disease and the bacteria present in their ga...

If anyone would like a news style article to read they can find one at news.utdallas.edu/health-medic.... Thank you for highlighting our work @nyupainresearch.bsky.social

Gut microbiota and metabolites drive chronic sickle cell disease pain in mice Individuals with sickle cell disease (SCD) suffer from debilitating chronic pain that does not have a clear etiology. Recent 16S ribosomal RNA gene se…

Amazing new paper from the Sadler Lab showing gut microbiota and metabolite contributions to pain in sickle cell disease. Congratulations to you and your team on this impressive work Kate! www.sciencedirect.com/science/arti... @katesadlerphd.bsky.social @utdpaincenter.bsky.social

These are representative images of mouse hindpaw skin stained with PGP9.5 (pan neuronal marker) and Dapi (nuclei stain) to look at intraepidermal nerve fiber density (IENF).

The first image is from healthy skin, the second is from a mouse with ongoing neuropathy.
#fluorescencefriday

Video of Diana Tavares-Ferreira discussing peripheral nerve damage and diabetes.

We are highlighting a new paper by @dianatavf.bsky.social published in @jclinical-invest.bsky.social. In this paper, they reveal how peripheral nerves shift towards inflammatory phenotypes in DPN.

🔬 Read the full study: utd.link/3df
📊 Explore the data: utd.link/3dg

This work is finally online as in-press preview!

JCI - Cell and molecular profiles in peripheral nerves shift toward inflammatory phenotypes in diabetic peripheral neuropathy www.jci.org/articles/vie...

🎤We are thrilled to announce that undergraduate researcher, Bhavya Jaiswal, has been awarded the American Physiological Society Summer Undergraduate Research Fellowship and has also received an award from the Texas Society for Microscopy (TSM) Small Grant Program. Congrats! 🔬🎉

Glutamatergic and GABAergic synapses in the human spinal dorsal horn revealed with immunohistochemistry Primary afferent neurons detect sensory stimuli in the periphery and transmit this information to the dorsal horn of the spinal cord, where it is extensively processed by excitatory and inhibitory spi...

New preprint from us led by @oliviadavis.bsky.social doing some fantastic work labeling synapses in the human dorsal horn. www.biorxiv.org/content/10.1... This work should lay an important foundation for many future studies.

🔬✨Fluorescence Friday!✨🔬

Pictured is a human dorsal root ganglion (hDRG). TRPV1 is in red, peripherin in green, CD31 in magenta, and DAPI in blue.

Image courtesy of Stephanie Shiers, Ph.D.

#fluorescencefriday #painneuroscience #painscience #MicroscopyMagic #neuroart

🔬Happy #FluorescenceFriday 🥳 Pictured is a human trigeminal ganglion labeled for five targets using two assays, immunofluorescence and RNAscope in situ hybridization! DAPI is in blue, peripherin is in green, SOX10 is magenta and two mRNAs (🤐 in red and cyan).

Image credit: Stephanie Shiers, PhD.

🎉 Huge Congratulations to Dayton Darabadey! 🎉
Happy to announce that Dayton has won the "Best Predoc Poster Presentation" at the 14th Annual GCC Translational Pain Research Conference! 🏆

FACULTY JOB ALERT! The Albert Einstein Dept of Neuroscience is hiring a new assistant professor in any area of neuroscience! We have funds specifically earmarked for this search. #Neuroscience #AcademicJobs #NeuroSky Job just posted: faculty-einstein.icims.com/jobs/17175/f... Please share widely!!

A woman in a white lab coat stands against a white background. Her face is obscured. Above her, the text reads 'CAPS | Grants.' Below this, the text states 'Merkin Center Research Grant Recipient' followed by 'Diana Tavares-Ferreira, PhD.' The description below reads: 'Diabetic peripheral neuropathy (DPN) is a common and debilitating complication of diabetes, caused by changes in the distal axons of sensory neurons. This project aims to investigate how disruptions in mRNA transport within peripheral nerves contribute to axonal degeneration in DPN, with the goal of uncovering insights that could lead to personalized treatments.' At the bottom right corner are images of two cats labeled as 'Lab Mascots' with names Nala and Max.

🎉 Thrilled to announce that Diana Tavares-Ferreira, PhD, was awarded a grant from the Merkin Peripheral Neuropathy and Nerve Regeneration Center. This grant supports her research into how disruptions in messenger RNA transport within peripheral nerves contribute to nerve degeneration. 🎉

📢 We're Hiring! Join Our Team at the Center for Advanced Pain Studies!!✨

If you are passionate about research and studying chronic pain or migraine, this is your opportunity.

Program Manager - utd.link/30k
Research Tech - utd.link/30l

#painneuroscience #research #job #scicomm #pain

Cortex, brain. Neurons (NeuN, magenta), axon initial segments (Ankyrin-G, green), nuclei (DAPI, blue)

🌷 Happy National Flower Day 🌷

Cortex, brain. Neurons (NeuN, magenta), axon initial segments (Ankyrin-G, green), nuclei (DAPI, blue)

#FluorescenceFriday #nationalflowerday #painneuroscience

Our program manager extraordinaire, Ayesha Ahmad, is leaving us, so we have an exciting position open to take on her role. jobs.utdallas.edu/postings/28956 In addition to this being an exciting position, you will also get to learn from Ayesha before she departs.

🌟 Meet Our Advocates: Greg Dussor,PhD, and Mandee Schaub! 🌟As participants in the Alliance for Headache Disorders Advocacy's Headache on the Hill event, they are dedicated to raising awareness and driving change for the 40+ million Americans affected by headache disorders.
#HOH2025

A community science event taking place outdoors in an urban park, with people of diverse backgrounds engaging in hands-on learning activities. A young girl with braided hair and colorful beads is interacting with a puzzle-like anatomy model at a table covered with educational materials, including a model of a skull, brain-shaped objects, and colorful food items. Volunteers and attendees, including a woman in a green shirt and another in a UT Dallas cap, are assisting participants in exploring the exhibits. The background features tall buildings, trees, and other activity booths with people engaged in various educational demonstrations.

A young man in a white sweater enthusiastically demonstrates a colorful neuron pipe cleaner model to a group of attendees at an outdoor science event. A young girl in a white shirt and a man in a red shirt watch attentively, while another volunteer in a green shirt, representing the "School of Behavioral and Brain Sciences" , works at the table. The table is covered with educational materials, including a brain model and interactive learning tools. The background features a park setting with concrete steps, grass, and people engaging in various activities under a sunny sky.

A lively outdoor science event in an urban park, where volunteers and attendees of diverse backgrounds engage in hands-on learning activities. A woman in a white shirt with a smiley face design enthusiastically gives a thumbs-up while standing near a table filled with educational materials, including anatomical models, food items, and scientific tools. Children and adults gather around as a volunteer in a green shirt holds up a model brain and explains a concept. The background features tall buildings, inflatable play structures, and people enjoying the event under a partly cloudy sky.

A diverse group of people, including children and adults, are gathered around an outdoor activity booth in a park setting. Two men behind the table are engaging with children, handing out educational materials related to the brain and neuroscience. The table is covered with colorful educational materials, including brain models, activity sheets, and small plush brain toys. The crowd appears engaged and interested, with children leaning in to interact with the materials. The event takes place on a grassy area with a concrete border, and other people can be seen in the background participating in similar activities.

🧠✨ This weekend, we had an amazing time at STEM Day in the Park! Families joined us for a hands-on journey into the brain and nervous system with interactive experiments.

We loved sparking curiosity and inspiring future scientists. 🚀🔬 #STEMDay #NeuroscienceFun #BrainPower

Human dorsal root ganglion (hDRG), green is beta 3 tubulin (a neuronal marker) and red is p-eIF2α (a marker of cellular stress)

hDRG, confocal microscopy, z-stack

🔬We study the dorsal root ganglion (DRG), which is a cluster of cells located just outside of the spinal cord. The DRG routes pain signals from the periphery to the central nervous system.

#FluorescenceFriday #sciart #neuroart

A great opportunity to learn about #mechanisms of #pain from the intervertebral disc at #USASP2025.
#LowBackPain #ChronicPain #Research @utdpaincenter.bsky.social

📢 We're Hiring! Join Our Team at the Center for Advanced Pain Studies!

✨ CAPS is looking for a research technician. If you are passionate about research and studying chronic pain or migraine, this is your opportunity.

🔗 Learn more and apply: UTD.link/2v7

Five facts about memory and the brain Memories of “firsts”—a first kiss, first love, first heartbreak—feel permanent. But why do we remember some moments yet forget others?

It's #BrainAwarenessWeek2025! Understanding the healthy #brain can help us understand how memories are formed and what goes wrong in neurodegenerative diseases like #Alzheimers. 🧠 @danafoundation.bsky.social #BrainWeek

Check out these five facts about the brain: www.stowers.org/news/five-fa...

Cleveland Clinic Model Predicts Risk of Early-Onset Colorectal Cancer, Precancerous Polyps Risk score helps to personalize colorectal cancer screening for patients under 45 years old

About half of patients diagnosed with early-onset colorectal cancer are younger than 45, earlier than the recommended age to start screening. We created a risk score to help find who could benefit from early screening.

More: cle.clinic/3QGIWyL

Transcriptomic and histological characterization of telocytes in the human dorsal root ganglion Telocytes are interstitial cells with long processes that cover distances in tissues and likely coordinate interacts with other cell types. Though present in central and peripheral neuronal tissues, t...

This paper: "Transcriptomic and histological characterization of telocytes in the human dorsal root ganglion" has now been accepted for publication in Journal of Comparative Neurology. Congrats to @ish1789.bsky.social and Stephanie Shiers in our lab. #NIHFunding pmc.ncbi.nlm.nih.gov/articles/PMC...

Photo collage with varying colors of blue watercolor as a background. There are two images, the top image is showing a group of people discussing science with a scientist in a lab coat. The bottom image shows two people in conversation.

We were delighted to welcome Rep. Rafael Anchía to our labs a couple weeks ago. We had an insightful discussion about the impact of chronic pain and migraines on Americans, and our efforts to develop non-opioid therapeutics.
#chronicpain #migraine #painresearch

Science is serious stuff, but sometimes it can’t help but make you smile.
Especially when it smiles first 😁

Stained image of a spinal cord, Neurons (magenta) microglia (cyan), and nuclei(blue)

✨ #FluorescenceFriday ✨

Check out this beautiful image of a stained spinal cord! Neurons (magenta) microglia (cyan), and nuclei(blue). 🧠🔬

#Neuroscience #ScienceArt #MicroscopyMagic #CellularBeauty #ResearchLife #painneuroscience

Mar 2025 Cover

Check out articles like “Epigenomic landscape of the human dorsal root ganglion: sex differences and transcriptional regulation of nociceptive genes” by Úrzula et al. in #PAIN bit.ly/41gonza

Article in Spanish about the research of Zulmary Manjarres. The article has a photo of Zulmary in the middle and discuss her research on pain and Parkinson's disease.

🎉Celebrating CAPS researcher, Zulmary Manjarres, PhD! She has been highlighted in a news article for her work on pain associated with Parkinson's disease. Zulmary is working with @katesadlerphd.bsky.social and @tedpricethepainguy.bsky.social to study the microbiome in different pain conditions. 🎉

We are thrilled to announce that Brodie Woodall received a Travel Award to attend USASP 2025!
This opportunity will allow her to connect with leading researchers, share insights, and explore the latest advancements in pain science.
#USASP2025 #TravelAward #PainResearch #educationmatters #painscience

Human dorsal root ganglion (hDRG). Three different mRNAs expressed in sensory neurons (green, magenta, cyan), nuclei (blue).

Human dorsal root ganglion (hDRG). Three different mRNAs expressed in sensory neurons (green, magenta, cyan), nuclei (blue).

RNAscope in situ hybridization.

#fluorescencefriday #painscience #painneuroscience #neuroart