Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall-targeting antimicrobials, combining RNAseq and high-resolution tilin...

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

#MolMicrobiol from Thorsten Mascher @spp2389.bsky.social, Rut Carballido-López and colleagues

onlinelibrary.wiley.com/doi/10.1111/...

Impressions of Bakteriopolis in Cosmo!
Come try out a new memory game, check out the microbe of the year Penicillium chrysogenum (@vaam-microbes.bsky.social), or travel through an interactive timeline on the origin of life 🦠

Don’t miss upcoming workshops on fungal mycelium on 30.04. and 05.05. 🍄

Our traveling exhibition Bakteriopolis is in the Cosmo Wissenschaftsforum this month! 🦠🔬

Come talk to scientists, learn about fermented foods, see the microbe of the year Penicillium up close and much more!

Every Tuesday - Thursday
13:00 - 18:00
Schloßstraße 2
01067 Dresden

A family of endonucleases blocks nanotube-mediated plasmid exchange - Nature Microbiology The YokF endonuclease provides a donor-controlled mechanism to limit plasmid transfer to recipient bacteria via nanotubes in Bacillus subtilis, with YokF functional homologues found across Gram-positi...

A family of endonucleases blocks nanotube-mediated plasmid exchange

YokF encoded within prophage

@natmicrobiol.nature.com from Sigal Ben-Yehuda, Ilan Rosenshine
with Boris Maček
within ERCSyG and @spp2389.bsky.social

www.nature.com/articles/s41...

What started out as a student project has grown over the last 2 years into a full-fledged review!

So many thanks to @escolizzi.bsky.social for leading this multicellular effort and sharing your evolutionary wisdom with us 🫶🏻🦠

A bacterial extracellular matrix protein forms a supramolecular metallogel
[=Bacillus subtilis TasA and Zn]

bioRxiv from Liraz Chai
with @vasilyzaburdaev.bsky.social within @spp2389.bsky.social

www.biorxiv.org/content/10.6...

Interested in the regulation and evolution of multicellularity in Strepromyces?
Natalia Tschowri (@unihannover.bsky.social) and Daniel Rozen (@unileiden.bsky.social) are looking for a PhD student as part of #SPP2389 !
#PhDposition

And we’re back! The second funding period of #SPP2389 started this week with our kickoff meeting in Grimma

Stay tuned in the next few weeks/months to get to know both the old and new members working on projects centered around the fascinating world of bacterial multicellularity! 🦠

Deciphering guanidine assimilation and riboswitch-based gene regulation in cyanobacteria for synthetic biology applications | PNAS Guanidine is well known as a denaturing agent. However, recent studies have demonstrated both the widespread synthesis of guanidine, e.g., in plant...

Our latest paper on Guanidine metabolism in #Cyanobacteria is out @pnas.org
(it's useful as N nutrient but toxic at the same time)

A great collaboration w Klähn lab w small part from us on toxicity😅
@hhu.de @spp2389.bsky.social
@sfb1381.bsky.social @mibinet.bsky.social
www.pnas.org/doi/10.1073/...

Last chance to visit Bakteriopolis at the @tudresden.bsky.social Excellence Days event!

Surface matters! Chitin alters both intraspecies interactions and biofilm architecture in Vibrio cholerae in marine snow

Preprint on @biorxiv-microbiol.bsky.social ⬇️

Cellulose is a critical component in the cell wall of Streptomyces, and accessory proteins involved in its biosynthesis support both its unique cell envelope and multicellular filamentous growth

From Daniel Claessens’ lab in @cp-trendsmicrobiol.bsky.social
#microsky #streptomyces #multicellularity

Bakteriopolis is in Halle at the #SilbersalzFestival this week! Even Come try water kefir, make your own bacterium, and learn about the hidden world of multicellular microbes! #SPP2389 #microsky #wisskomm

Danke an Mainzelmännchen Det für den Besuch! @zdfde.bsky.social

@kostchristian.bsky.social has an open PhD position as a part of #SPP2389 !
#microsky #mevosky

Evolution of One Species Increases Resistance to Invasion in a Simple Synthetic Community - Microbial Ecology The species that make up a microbial community determine its potential function. A major goal of microbial ecology is to make assemblages of microbes — synthetic communities — with targeted applicatio...

Evolution of One Species Increases Resistance to Invasion in a Simple Synthetic Community

Microbial Ecology

link.springer.com/article/10.1...

I’ll second MYM! Seems to be a good allrounder for most of the natural isolates we’ve worked with

Interested in working on microbial interactions and cooperative cross-feeding? Join @kostchristian.bsky.social as a part of #SPP2389 !

From polymicrobial water kefir grains to PCD in biofilms, microorganisms are magnificently multicellular!
Thanks to @embo.org @ibe-barcelona.bsky.social for having Lena Friebel and Thorsten Mascher @tudresden.bsky.social as well as @escolizzi.bsky.social at the
#Multicellverse workshop

You can’t talk about microbial multicellularity without mentioning Streptomyces - check out our collaborator Daniel Rozen’s experimental evolution of these filamentous bacteria!
Thanks @martaalvarez.bsky.social for snapping a pic!
@embo.org #Multicellverse

Our head of #SPP2389 Thorsten Mascher also put the spotlight on the multicellular microbial communities of water kefir - thanks again @evolvedbiofilm.bsky.social !
@embo.org #Multicellverse

Lena brought her research on cannibalism in Bacillus biofilms to the @embo.org multicellularity workshop! Thanks @evolvedbiofilm.bsky.social for the picture! #Multicellverse

Protein condensates determine a cell’s fate Do cells contain a mechanism that decides on their fates? Researchers at ETH Zurich have demonstrated in a new study that large clusters of molecules determine a cell’s future.

All cells – from mammalian cells to microbes – can follow different biological paths. Whether they grow and divide, specialise, age or die depends on the pathway they take. New findings by researchers at ETH Zurich could help influence a cell’s decisions to target diseases such as cancer.

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade Biological sciences; Biochemistry; Microbiology; PII-like protein SbtB; c-di-AMP signaling; Cyanobacteria; Carbon/Nitrogen metabolism; Redox imbalance; Photosynthesis; Reactive oxygen species (ROS); C...

A bit late 🙃 but happy to share our recent findings on #cdiAMP signaling in controlling #cyanobacteria #diurnal rhythm in @cp-iscience.bsky.social

www.cell.com/iscience/ful...

#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social

PhD position on Regulation and Evolution of Bacterial Multicellularity ( #Streptomyces ) within @spp2389.bsky.social supervised by Natalia Tschowri (Hannover 🇩🇪) and Danny Rozen (Leiden 🇳🇱) with research at both locations

deadline: October 31, 2025

www.uni-hannover.de/en/jobs/id/802

Streptomyces and other filamentous actinomycetes are treasure troves of a vast collection of antibiotic compounds - an evolutionary feature linked to their unique multicellular lifestyle

Curious about kin recognition systems? Take notes from Proteus and Myxococcus!
@ucberkeleyofficial.bsky.social

International Microorganism Day - Microbe Art Contest Winners

Congratulations to our Matthias for winning the @femsmicro.org international microorganism day microbe art contest for best photo and best overall! 🎉🦠
Biofilms truly are beautiful works of multicellular microbial architecture 🏛️

www.internationalmicroorganismday.org/microbeart

A bit late to the party, but happy belated international microorganism day!

The what, when, where, and why of wrinkly morphology in biofilms Wrinkling is a striking emergent behavior that occurs in microbial biofilms across many species. The phenomenon originates from an intricate interplay between e

The what, when, where, and why of wrinkly morphology in biofilms

-in Biophysics Rev

pubs.aip.org/aip/bpr/arti...

We loved hearing @khammerschmidt.bsky.social talk about evolution at the #MultiBac2025 conference this January - check out the @asm.org report on the origins of early microbial life!