Mycobacterial RadA Functions in Cyclic Di‐AMP Mediated Homologous Recombination in Addition to Supporting RecA Activity Mycobacterium harbors distinct DNA repair pathways absent in E. coli, crucial for virulence and survival. Cyclic di-AMP regulates recombination, genome stability, and SOS response. RadA, with disA in...

🫴 Mycobacterial RadA Functions in Cyclic Di-AMP Mediated Homologous Recombination in Addition to Supporting RecA Activity:

Molecular Microbiology | Microbiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

#cdiAMP

@archaellum.bsky.social lab reveals how #cdiAMP and 4 RCK proteins shape osmotic stress responses in H. volcanii 🧬🦠. In highly halophilic #archaea, c-di-AMP coordinates ion balance and cell volume—mirroring bacterial strategies for environmental stress adaptation.

👉 buff.ly/ApWkCtg

Cyclic di-AMP inhibits Listeria monocytogenes thymineless death during infection | mBio Consuming food contaminated with Listeria monocytogenes (Lm) can cause severe listeriosis, a leading foodborne illness with a 20% fatality rate. Most cases require hospitalization, and 25% of pregnanc...

👉 Cyclic di-AMP inhibits Listeria monocytogenes thymineless death during infection!

👇👇👇

| mBio journals.asm.org/doi/10.1128/...

@mbio.bsky.social #Listeria #cdiAMP

Staying in the loop to make ends meet: roles and regulation of GlmR in Bacillus subtilis The metabolic networks of most life forms integrate cost-benefit analysis to properly budget carbon and other essential nutrients through continuous assessment of nutrient availability and environment...

🥸 Staying in the loop to make ends meet: roles and regulation of GlmR in Bacillus subtilis:

www.biorxiv.org/content/10.1...

#subtiwiki #cdiAMP #subtilis

This add on to the functional catalog of #cdiAMP by showing it's involvement in ROS balance, photosyn., motility & proteome stability to regulate day-night switches in #cyano

part of this work was done by my former PhD, Michael Haffner @cmfi.bsky.social and some support by @sfb1381.bsky.social ...

Diurnal rhythm causes metabolic crises in the cyanobacterial mutants of c-di-AMP signaling cascade Biological sciences; Biochemistry; Microbiology; PII-like protein SbtB; c-di-AMP signaling; Cyanobacteria; Carbon/Nitrogen metabolism; Redox imbalance; Photosynthesis; Reactive oxygen species (ROS); C...

A bit late 🙃 but happy to share our recent findings on #cdiAMP signaling in controlling #cyanobacteria #diurnal rhythm in @cp-iscience.bsky.social

www.cell.com/iscience/ful...

#cdiAMP is involved in almost all cellular processes, explaining it's essentiality in #cyano
@hhu.de
@mibinet.bsky.social

#cdiAMP Small molecule w/ big roles
We showed that #cdiAMP plays an essential role in regulating natural competence and DNA 🧬 uptake in #cyanobacteria through controlling pilus biogenesis
a great collaboration with @archaellum.bsky.social

Could be interesting for community @cyanotrans.bsky.social

The second messenger c-di-AMP controls natural competence via ComFB signaling protein Cell Discovery - The second messenger c-di-AMP controls natural competence via ComFB signaling protein

Happy to share our latest finding @natureportfolio.nature.com on #cdiAMP signaling roles in #cyanobacteria natural competence via #ComFB (a new family of #cdiNMP receptors)
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT

Wow: doi.org/10.7554/eLif...

#cdiAMP #chlamydia @elife.bsky.social

Borrelia burgdorferi c-di-AMP is a key extracellular pathogen-associated molecular pattern to elicit type I interferon responses in mammalian hosts Abstract. Borrelia burgdorferi (or Borreliella burgdorferi), the extracellular spirochete responsible for Lyme disease, elicits a type I interferon (IFN-I)

🫴 Borrelia burgdorferi c-di-AMP is a key extracellular pathogen-associated molecular pattern to elicit type I interferon responses in mammalian hosts:

academic.oup.com/jimmunol/art...

#cdiAMP #Borrelia

Very cool study showing how to deal with protein flexibility in cryoEM with very short blotting time in ms of #cdiAMP target KtrA...
Also #cdiAMP was crucial to stabilize the flexibility and enhance cryoEM map

www.sciencedirect.com/science/arti...

Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome - Nature Chemical Biology Cyclic dimeric adenosine monophosphate is found to be a second messenger in eukaryotic cells that is generated by adenylate cyclase 7 and connects Toll-like receptor 9 stimulation to nucleotide-bindin...

👉 c-di-AMP is synthesized in eukaryotes: The second messenger activates the NLRP3 inflammasome!

👇👇👇

www.nature.com/articles/s41...

www.nature.com/articles/s41...

@natchembio.nature.com #cdiAMP

Big News (a bit late 🙃): my group is moving to Düsseldorf
@hhu.bsky.social

Looking for next adventure w awesome colleagues @frunzkelab.bsky.social @kedrov-lab.bsky.social @apmweber.bsky.social

Plz RT, positions available for #PhD & #postdoc w focus #CryoEM & #cdiAMP

www.hhu.de/news-einzela...