New Bacterial Motility and DNA Transfer Mechanism Uncovered

Researchers identified the ComFB receptor that binds c‑di‑GMP and c‑di‑AMP, linking flagellar rotation to natural competence in bacteria such as Bacillus subtilis and Vibrio cholerae. Read more: getnews.me/new-bacterial-motility-a... #bacteriamotility #comfb

And w/ Dubnau lab. & Congrats to my PhD student Sherry for this terrific job!

In this study, we show that #ComFB #singling proteins represent a new family of #cdiGMP receptors from phylogenetically distant bacteria ( #Bacillus, #Vibrio, Thermoanaerobacter and #Treponema).

#SubtiWiki

c-di-GMP-Dependent Regulation of Motility by comFB and comFC ComFB is encoded in the comF operon of Bacillus subtilis, situated between the genes for ComFA and ComFC. The latter two proteins are essential for natural transformation, whereas ComFB is dispensable...

Happy to see #ComFB role on motility machinery is expanding to #Bacillus via #cdiGMP signaling
A great collaboration w/ Dubnau Lab w/ contribution from us on the protein biochem part @hhu.de & @cmfi.bsky.social
Funding @dfg.de @sfb1381.bsky.social @mibinet.bsky.social
www.biorxiv.org/content/10.1...

The second messenger c-di-AMP controls natural competence via ComFB signaling protein Cell Discovery - The second messenger c-di-AMP controls natural competence via ComFB signaling protein

Happy to share our latest finding @natureportfolio.nature.com on #cdiAMP signaling roles in #cyanobacteria natural competence via #ComFB (a new family of #cdiNMP receptors)
@hhu.de @cmfi.bsky.social @biologyunifreiburg.bsky.social
Fund @dfg.de @sfb1381.bsky.social
@mibinet.bsky.social
rdcu.be/eyLXT