PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

🫴 Distinct PlzC mechanisms integrate chemotaxis and c-di-GMP signaling to regulate Vibrio cholerae motility and biofilm formation:

www.pnas.org/doi/10.1073/...

@pnas.org #cdiGMP #vibrio

And w/ Dubnau lab. & Congrats to my PhD student Sherry for this terrific job!

In this study, we show that #ComFB #singling proteins represent a new family of #cdiGMP receptors from phylogenetically distant bacteria ( #Bacillus, #Vibrio, Thermoanaerobacter and #Treponema).

#SubtiWiki

c-di-GMP-Dependent Regulation of Motility by comFB and comFC ComFB is encoded in the comF operon of Bacillus subtilis, situated between the genes for ComFA and ComFC. The latter two proteins are essential for natural transformation, whereas ComFB is dispensable...

Happy to see #ComFB role on motility machinery is expanding to #Bacillus via #cdiGMP signaling
A great collaboration w/ Dubnau Lab w/ contribution from us on the protein biochem part @hhu.de & @cmfi.bsky.social
Funding @dfg.de @sfb1381.bsky.social @mibinet.bsky.social
www.biorxiv.org/content/10.1...