Advertisement · 728 × 90

Posts by Norman van Rhijn

Antarctic marine microplastics reveals environmental persistence and rapid evolution of Candida auris Candida ( Candidozyma ) auris is a critical priority fungal pathogen that emerged two decades ago near simultaneously on multiple continents. Since emergence, C. auris resistance to all four classes of antifungal drugs has been described, including pan-drug resistant isolates, sometimes evolving in-patient. Here, we confirm the first isolation of C. auris from Antarctica and show cold-adapted phenotypes and an affinity for binding to nylon. We also provide evidence to suggest mutator phenotypes contribute to the rapid evolution in C. auris and are responsible for the emergence of multiple, distinct genetic clades worldwide. Isolates in clades I, III and IV with a mutator phenotype displayed elevated mutation rates compared to non-auris Candida species. This phenotype had a complex genetic basis and was associated with drug resistance mutations. We postulate that the mutator phenotype has a significant effect on evolutionary potential and is responsible for the emergence and rapid spread of drug-resistance C. auris and novel genetic clades. ### Competing Interest Statement This work was partially support by a Wellcome Trust Institutional Strategic Fung Springboard Fellowship awarded to JR. PH and JR were funded through a JPIAMR IMPACT grant (JPIAMR2024_IMPACT-197 Consortium grant: FuGACI) and the Dutch Organisation for knowledge and innovation in health, healthcare and wellbeing (ZonMw) under project number 10570172410003. NvR is supported by a Wellcome Trust fellowship (226408/Z/22/Z). MCF is a fellow of the Canadian Institute for Advanced Research (CIFAR). RAF is supported by a Wellcome Trust Career Development Award (225303/Z/22/Z). JLS is a Howard Hughes Medical Institute Awardee of the Life Sciences Research Foundation. SD and HG are supported by the MRC Centre for Medical Mycology at the University of Exeter (MR/N006364/2 and MR/V033417/1), and the MRC Doctoral Training Grant (MR/P501955/2), and the NIHR Exeter Biomedical Research Centre. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. We also thank the Exeter Sequencing Service facility and support from Wellcome Trust Institutional Strategic Support Fund (WT097835MF), Wellcome Trust Multi User Equipment Awards (WT101650MA and 218247/Z/19/Z), Medical Research Council Clinical Infrastructure Funding (MR/M008924/1) and BBSRC LOLA award (BB/K003240/1), as well as the University of Exeter High-Performance Computing (HPC) facility, funded by the UK MRC Clinical Research Infrastructure Initiative (award number MR/M008924/1). Wellcome Trust, https://ror.org/029chgv08, Strategic Fung Springboard, 226408/Z/22/Z, 225303/Z/22/Z JPI-AMR, JPIAMR2024_IMPACT-197 Consortium grant: FuGACI ZonMw, The Dutch Organisation for knowledge and innovation in health, healthcare and well-being, 10570172410003 CIFAR Howard Hughes Medical Institute Awardee of the Life Sciences Research Foundation MRC Centre for Medical Mycology at the University of Exeter, MR/N006364/2, MR/V033417/1 MRC Doctoral Training Grant, MR/P501955/2 NIHR Exeter Biomedical Research Centre BBSRC, BB/W009625/1 MRC, MR/4002163/1

Excited to share our latest work:
“Antarctic marine microplastics reveals environmental persistence and rapid evolution of Candida auris.”

www.biorxiv.org/content/10.6...

This study explores how environmental microplastics may act as reservoirs for Candida auris.

🧵

1 month ago 12 5 1 0
Post image Post image Post image

Day 1 of the Brazilian Network Meeting on A fumigatus and Antimicrobial Resistance🌳🍄🌾

A wonderful day on a beautiful campus, the air samplers are out and we are ready for a day of fruitful discussions 🤝

4 months ago 4 1 0 0
Post image

A long time ago in this same galaxy, we asked ourselves "where does azole antifungal resistance in fungi come from?"

So we set about sampling Aspergillus fumigatus to build a collection of 1000+ samples spanning a century from 34 countries.

5 months ago 17 4 1 0
Preview
Antifungal treatment strategies and their impact on resistance development in clinical settings Abstract. Invasive fungal diseases, particularly among immunocompromised patients, represent a growing clinical challenge due to limited therapeutic option

nterested in clinical approaches to mitigate antifungal resistance development?! 🚨

Our latest review article in Journal of Antimicrobial Chemotherapy we explore important diagnostics and determinants for resistance

academic.oup.com/jac/advance-...

5 months ago 3 0 0 0
https://www.bmh.manchester.ac.uk/study/research/funding-fees/funding-opportunities/csc-scholarship/

🚨PhD opportunity

The China Scholarship Council (CSC-UoM) Joint Scholarship Programme is to support outstanding Chinese researchers for PhD studies at the University of Manchester and nominations are now open.

More information can be found at: www.bmh.manchester.ac.uk/study/resear...

6 months ago 0 0 0 0
Kre6-dependent β-1,6-glucan biosynthesis only occurs in the conidium of Aspergillus fumigatus You have to enable JavaScript in your browser's settings in order to use the eReader.

New publication🚨Long term collaborations pay off!

I met Jean-Paul 8 years ago in France 🇫🇷 where he told me he doubted that A. fumigatus cell wall did not contain any B1,6-glucan🤷 (random conversation)

Now we have shown it! ssNMR to the rescue👌

journals.asm.org/doi/epub/10....

7 months ago 4 0 0 0

@bsmm-meeting.bsky.social

7 months ago 0 0 0 0
Post image Post image Post image

Another great British Society for Medical Mycology meeting👌 Thanks to all @forestcita.bsky.social Stefan Bidula Isabelle Storer Georgie Middleton for organising

Saying goodbye as my role as Early Career Representative🙋‍♂️but saying Hello as my new elected role as Treasurer Elect 💷

7 months ago 7 2 2 0
Research Associate (PDRA) in Fungal Infection Biology :Oxford Road The Bertuzzi’s laboratory at the Manchester Fungal Infection is looking for two outstanding candidates be part of an interdisciplinary team of researchers, working on an Wellcome Trust funded project investigating how Mucorales fungi adapt to natural and in-host environments and how stress adaptation drives infection. The posts are available from the 5th of January 2026 on a full-time basis for 3 years, with the possibility to extend.

JOB ALERT @bertuzzilab.bsky.social is recruiting 2 Research Associates for a project on Mucorales! Very exciting and can definitely recommend working with this group ☺️

www.jobs.manchester.ac.uk/Job/JobDetai...

7 months ago 8 9 0 0
Advertisement
Preview
Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...

Does your lab perform killing assays?
TL;DR: we’ve identified a problem that can bias the outcome of killing assays, making antagonism look stronger than it really is.
Adding a simple extra step can mitigate this bias!

Out now at #MicrobioJ www.microbiologyresearch.org/content/jour...

1/n

7 months ago 40 20 1 1

A long long longgg time ago this was just a table and some data 🤭

But turned it into what I think is a great resource!

8 months ago 10 1 1 0

Our latest review is out!!🎉🎊

8 months ago 1 0 0 0

Thank you!

9 months ago 0 0 0 0
Post image

Truly honoured to have been recognised as a Fellow of the European Confederation of Medical Mycology 🏅
Looking forward to many years of research 🧫🔬
#ECMM #MedicalMycology

9 months ago 11 2 1 0

Exciting opportunities to join me in this research will be coming soon! If you're passionate about understanding microbial evolution & tackling antimicrobial resistance, keep an eye out or feel free to get in touch. 🔬🧬 🍄 #AMR #Microbiology #Evolution

9 months ago 16 9 1 1

Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.

9 months ago 22 15 0 0
Health risks with environmental changes and mould exposure. Key impacts of flooding include increased precipitation, rising sea levels and land use changes, leading to indoor mould growth and health risks such as respiratory issues, asthma exacerbation and mould infections. Case studies highlight varying health outcomes from Hurricane Katrina and Rita (2005), Colorado Flood (2013) and Hurricane Harvey (2017).

Health risks with environmental changes and mould exposure. Key impacts of flooding include increased precipitation, rising sea levels and land use changes, leading to indoor mould growth and health risks such as respiratory issues, asthma exacerbation and mould infections. Case studies highlight varying health outcomes from Hurricane Katrina and Rita (2005), Colorado Flood (2013) and Hurricane Harvey (2017).

Drivers of emerging fungal pathogens in a changing world. Climate change factors, such as rising temperatures and increasing resistance to fungicides, enhance fungal thermotolerance and drive the emergence of pathogens. Social determinants, including urbanisation, global travel and limited healthcare access, heighten human vulnerability to fungal infections. Other contributing factors, like environmental niches and unconfirmed environmental sources, further support the spread and persistence of fungal pathogens. These drivers contribute to the emergence of pathogens like Candida auris, Candida orthopsilosis and Cryptococcus deuterogatii.

Drivers of emerging fungal pathogens in a changing world. Climate change factors, such as rising temperatures and increasing resistance to fungicides, enhance fungal thermotolerance and drive the emergence of pathogens. Social determinants, including urbanisation, global travel and limited healthcare access, heighten human vulnerability to fungal infections. Other contributing factors, like environmental niches and unconfirmed environmental sources, further support the spread and persistence of fungal pathogens. These drivers contribute to the emergence of pathogens like Candida auris, Candida orthopsilosis and Cryptococcus deuterogatii.

Climate change and antifungal resistance: key mechanisms and pathogen examples. Climate change drives the development of antifungal resistance through mechanisms such as environmental pollution with fungicides, prolonged heat stress and increased mutation rates in fungi. These conditions promote genetic mutations, increased resistance to antifungal drugs and more challenging infections in humans and plants

Climate change and antifungal resistance: key mechanisms and pathogen examples. Climate change drives the development of antifungal resistance through mechanisms such as environmental pollution with fungicides, prolonged heat stress and increased mutation rates in fungi. These conditions promote genetic mutations, increased resistance to antifungal drugs and more challenging infections in humans and plants

Climate change: shifting boundaries of fungal disease in Europe and beyond

New review in Thorax

by @mbottery.bsky.social Sarah Sedik @germhuntermd.bsky.social @martinhoenigl.bsky.social @normanvanrhijn.bsky.social

thorax.bmj.com/content/thor... #MedSky #IDSky #PulmSky #ClimateSky #MedMycoSky

10 months ago 30 17 1 0
Advertisement
Post image Post image Post image

🚨Our latest review in Thorax about the impact of climate change focusing on fungal pathogens in Europe 🌍

A truly enjoyable collaboration with Sarah Sedik @germhuntermd.bsky.social @martinhoenigl.bsky.social and @mbottery.bsky.social

thorax.bmj.com/content/earl...

10 months ago 27 14 0 0

Last week as part of Cohort III I finished the Leading for Research Fellows programme🙌🔥

Most interesting to talk to Research Fellow from all over the university that run into the same barriers😅 (a lot of job security talks)

10 months ago 1 1 0 0
Preview
Full Show: The throne speech, Opposing Bill 15 & Deadly fungus Mornings with Simi · Episode

Another exciting chat this morning live on CKNW (Canada) about the hidden threat of fungal infection 🍄‍🟫🦠🧫

open.spotify.com/episode/0Rt4...

10 months ago 2 0 0 0
Preview
Deadly Fungi Are Here, and They’re Spreading Unlike “The Last of Us,” virulent fungal disease isn't a work of science fiction.

Fascinating article about @normanvanrhijn.bsky.social work on the affects of climate change on fungi & fungal infections, with comments from MRC CMM's Elaine Bignell www.bloomberg.com/opinion/arti...

10 months ago 6 4 0 0

More and more attention for fungal infections. Some of our work now featured by Bloomberg 📰

www.bloomberg.com/opinion/arti...

10 months ago 3 1 0 0
Preview
Study: Climate change enhances threat of infection-causing fungi to Europe Researchers from The University of Manchester have forecast there will be an increased risk of infection from fungi over the coming years, including a significant spread of some fungal pathogens acros...

🌡️ The rise of pathogenic #fungi is being driven by #climatechange. A new study led by @normanvanrhijn.bsky.social from 🇬🇧 @uniofmanchester.bsky.social, with colleagues from 🇬🇧 @lstmnews.bsky.social and 🇬🇧 @ukceh.bsky.social predicts significant spread of certain fungal pathogens in Europe.

11 months ago 2 3 0 0
Post image

Brazilian TV had a long section about fungal pathogens, AMR and the future risks of fungi🔥thoroughly enjoyed the filming day!

Highlighting research from Brazil and how we in the UK collaborate across the globe 🌍 to bring awareness for fungal diseases

11 months ago 12 1 2 0
Preview
Onderzoek: dodelijke schimmels rukken op in Europa Door de opwarming van de aarde neemt de hoeveelheid pathogene schimmels - oftewel schimmels die mensen ziek kunnen maken - in Europa de komende jaren steeds verder toe. Wetenschappers waarschuwen dat…

Article in Dutch🇳🇱:

Interview met RTL Nieuws over problemen nu en in de toekomst met schimmelinfecties🧫 en een oproep aan de gezondheidszorg, overheid maar ook boeren en gebruikers van antischimmels om in gesprek te gaan

www.rtl.nl/nieuws/buite...

11 months ago 1 0 0 0

Congrats Harry!! So well deserved

11 months ago 0 0 1 0
Post image Post image

Today we’re being filmed in the laboratory tomorrow talk about fungal diseases 🧫 and aspergillosis 🍄for Brazilian television 🇧🇷

Spreading awareness across the globe!

11 months ago 9 0 2 0
Advertisement

DEADLINE IS NEAR!! Register and submit your abstract before 30th May!!
Join us!! 7th-9th September 2025 for the BSMM 59th annual conference at Norwich Assembly house
@normanvanrhijn.bsky.social @elenaroselletti.bsky.social #Norwich2025 #BSMM2025 bsmm.org/BSMM_2024/bs...

11 months ago 2 4 0 1
Post image

Felt surreal to be live on Sky News Breakfast talking about fungal pathogens and climate change🍄‍🟫🗺️

Hopefully more people will learn about the wonderful (and scary) world of fungi this way

11 months ago 19 3 1 0
Details of merman presentations today and tomorrow.

Details of merman presentations today and tomorrow.

More amazing science from @mermanchester.bsky.social at #microbio25 today beginning with @normanvanrhijn.bsky.social ‘s talk this morning and Deepanshi’s poster over lunch!

1 year ago 12 3 0 1