Changing the Way We See Disease The Rhodes Trust is an educational charity which brings together and develops exceptional people who are impatient with the way things are and have the courage to act.

In conversation with @rhodeshouse.ox.ac.uk about how we define disease and how that shapes everything from mechanism to care. This piece reflects some of the questions that led me to my current 🔬 work.

Ft. @ndorms.bsky.social @ajclarke.bsky.social @ox.ac.uk @utoronto.ca @healthsciences.mcgill.ca

Really inspiring work Anne!

The adaptor protein TASL is required for age-related B cell emergence and lupus-like disease development in mice Systemic lupus erythematosus is a chronic autoimmune disease that mostly affects women and it is associated with genetic variants in the X-linked gene encoding the adaptor protein TASL. This study…

SLE (#lupus) is associated with genetic variants in the X-linked gene TASL. Julia Johnstone, @ajclarke.bsky.social &co show that TASL is required for B cell activation, age-associated B cell formation and lupus-like disease #InMice, suggesting its potential as a therapeutic target 🧪

Altered B cell activation contributes to the immunopathogenesis of childhood arthritis-associated uveitis - Nature Communications Juvenile idiopathic arthritis (JIA) associated uveitis can cause vision loss in children, but mechanisms remain unclear. The authors here identify elevated CD19+IgD-CD27- double negative type 1 B cell...

Very proud that our investigating uveitis pathogenesis in young people living with arthritis is out today @natcomms.nature.com. A real team science effort made possible by collaborations across hospital & researchers with support of patients. Check it out 👇
www.nature.com/articles/s41...

Great work Lizzy and team!

Single Cell Glucose Uptake Assays: A Cautionary Tale Assays to monitor the metabolic state or nutrient uptake capacity of immune cells at a single cell level are increasingly in demand. One assay, used by many immunologists, employs 2-(N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)Amino)-2-Deoxyglucose ...

****2-NBDG does not measure glucose uptake****

Just your regular reminder of this fact 😁.

See the rigorous proof of this fact in @lindavsinclair.bsky.social 2020 paper.

This paper was 6 years ago!! Stop using 2NBDG to measure glucose uptake already 🙄

pmc.ncbi.nlm.nih.gov/articles/PMC...

Really great work Michelle and team!

Congratulations Anne!

Anne Xuan-Lan Nguyen

🎉 Congratulations to Dr. Anne Xuan-Lan Nguyen for being awarded a Fighting Blindness Canada 2025 Clinician-Scientist Emerging Leader award! The award recognises her work on preventing sight-threatening complications of thyroid eye disease. https://bit.ly/4a7xGX0

Immunometabolism researchers are meeting in Newcastle on 16-17 April!

Join us for 2 days of fantastic immunometabolism research, Bright Sparks sessions & networking with the community. #UKimmunomet26

Submit your abstract by 5 March and register now 👉 https://bit.ly/493uE45

Tumor-draining Lymph nodes - Online event next week!
follow the link to register

On January 13 from 11:30 – 1:00 pm ET, @thelundlab.bsky.social , Dr. Ivan Maillard, @actonlab.bsky.social , & Dr. Burkhard Ludewig will discuss lymph node remodeling in cancer:

events.cancer.gov/dcb/tdln #TLDNForums

Don't miss out on your chance to attend "Fuelling the immune response IV: #UKimmunometabolismMeeting2026"

Those that have joined before will know these are fantastic meetings providing an open & productive forum to discuss really cool science

📆16-17th April

www.immunology.org/events/fuell...

Prof Alex Clarke wins ERC Consolidator Grant Prof Alex Clarke, Associate Professor at the Kennedy Institute and Honorary Consultant Rheumatologist, has received a prestigious €2m European Research Council (ERC) Consolidator Grant to study cellul...

Congratulations to Prof Alex Clarke, who has received a prestigious €2m European Research Council Consolidator Grant to study cellular metabolism in lymphoid tissues! www.kennedy.ox.ac.uk/news/prof-al...

Celebrating the end of a long 2025 ✨
Grateful for the people, the science, and the moments of community along the way, from our lab Christmas dinner to the department’s Christmas lunch 🕯️
Wishing you all a restful and joyful holiday season🎄
#HappyHolidays #Itisalmost2026

🚨 New preprint from the lab!
We’re excited to share “Improving population-scale disease prediction through multi-omics integration” by Ng et al. www.medrxiv.org/content/10.1...

Congratulations Nick!

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function - Nature Communications α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase, and its expression in CD4 + T-cells has been linked to remission status in rheumatoid arthritis. Here the authors repo...

Ecstatic to share out latest research looking at the role of mitochondrial ABHD11 in controlling T-cell responses. We think this may be a viable target for autoimmunity. Please do give it a read, we would love to hear your thoughts.

www.nature.com/articles/s41...

Really thrilled to have been involved in this project. It’s an absolute mammoth of a paper looking at the way T-cell leukaemia exploits inflammation to colonise the meninges. Congratulations to Nitesh and @kseniam.bsky.social 🍸

Please give it a read!

www.jci.org/articles/vie...

Canagliflozin synergises with serine restriction mediating anti-leukaemic effects in T-cell acute lymphoblastic leukaemia T-cell acute lymphoblastic leukaemia (T-ALL) is a haematological malignancy commonly driven by NOTCH1 activating mutations. A concomitant feature asso…

Really pleased to share the labs first publication in paediatric T-cell leukaemia. We find that the type 2 diabetes drug canagliflozin possesses anti-leukaemic effects that can be enhanced via dietary restriction of serine.

www.sciencedirect.com/science/arti...

A purple and white poster reads 'The Kennedy Institute of Rheumatology External Seminar: The promise of proteomics: insights into autoimmune disease pathogenesis and translational potential'. The speaker is Dr James Peters from Imperial College London. 20 October 2025, in the Kennedy Lecture Theatre, 12:00-13:00. Open to all members of the University of Oxford. Hosted by Alex Clarke.

On Monday 20 October, Dr James Peters will join us to present 'The promise of proteomics: insights into autoimmune disease pathogenesis and translational potential'. Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/ef1...

Do you want to do a PhD with me and Mike Devine? Of course you do! Or if not, maybe you know someone who does? @devinelab.bsky.social www.crick.ac.uk/careers-stud...

New preprint from the lab! Lactate, a tumor-derived metabolite, blocks B cells from entering tumors and forming tertiary lymphoid structures (TLSs). Congratulations Victoire Boulat - in a great collaboration with Anita Grigoriadis! tinyurl.com/3vvk9kec #Immunology #TLS #CancerMetabolism #Bcells

🌟 Postdoc Opportunity – MRC CoRE in Exposome Immunology 🌟
Join us to explore how the exposome shapes complex disease risk using multi-omics & global biobank data. @kiroxford.bsky.social , @exposomeimmunology.bsky.social

✅ Apply: lnkd.in/gJHJDvKn

🗓️ Deadline: 12pm, 30 Oct 2025

Become part of our new MRC Centre, working across Manchester and Oxford to solve a major challenge of our time - how does the immune system become dysregulated by environmental exposures to cause chronic disease.
www.manchester.ac.uk/exposome-jobs
@exposomeimmunology.bsky.social

SOOOOO excited to see this online IN REAL-LIFE!!

Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪

A shoutout to the event organizers and presenters! Also, to the Clarke Lab, which received several awards this year 🏆

#Rheumatology #Immunology #KISS2025 #OxfordResearch #OxfordUni

Woman sitting at a microscope Fully-funded four-year PhD studentships available at the Kennedy Institute in Oxford

🔬 🧫 🖥️ 🧬 Applications are now open to study at the Kennedy Institute @kiroxford.bsky.social next year!

Look at available projects, meet our supervisors and find out what it’s like studying at the University of Oxford. www.kennedy.ox.ac.uk/study

The Kennedy Institute Student Symposium | Day 1 💡

Hosted by the kiroxford.bsky.social!

Such a brilliant day filled with science, multidisciplinary ideas, and inspiring presentations.

It was wonderful to hear about everyone’s projects and to get thoughtful feedback on my own!

Great work Tom!

Metabolic control of innate-like T cells - Nature Reviews Immunology Functional and metabolic properties of innate-like T cells — namely, iNKT cells, MAIT cells and some γδ T cells — differ from those of conventional T cells. This Review describes how metabolic pathway...

Just in time for #Cd1Mr12025

Our Review on Innate-like T cell Metabolism is out!

Access free here: rdcu.be/eEV67

Please share with your Immunometabolism friends!

@cd1mr1.bsky.social
@lji.org @uniklinikkoeln.bsky.social
@natureportfolio.nature.com @natrevimmunol.nature.com