Testosterone is not simply “fuel.”
Small amounts may actually stimulate monomer prostate cancer growth…
…but high levels of testosterone can create dimers which suppress prostate cancer growth
#InMice
Safi 2024 Androgen receptor monomers and dimers
www.nature.com/articles/s41...
SLE (#lupus) is associated with genetic variants in the X-linked gene TASL. Julia Johnstone, @ajclarke.bsky.social &co show that TASL is required for B cell activation, age-associated B cell formation and lupus-like disease #InMice, suggesting its potential as a therapeutic target 🧪
SLE (#lupus) is associated with genetic variants in the X-linked gene TASL. Julia Johnstone, @ajclarke.bsky.social &co show that TASL is required for B cell activation, age-associated B cell formation and lupus-like disease #InMice, suggesting its potential as a therapeutic target 🧪
SLE (#lupus) is associated with genetic variants in the X-linked gene TASL. Julia Johnstone, @ajclarke.bsky.social &co show that TASL is required for B cell activation, age-associated B cell formation and lupus-like disease #InMice, suggesting its potential as a therapeutic target 🧪
Why does #fat expand differently in distinct body regions? Yan Li, Carlos Ibáñez, Meng Xie &co identify Gpc3 as a gene that selectively promotes the expansion of white adipose tissue in specific body areas in mice fed a high fat diet.
🧪 #metabolism #InMice
Why does #fat expand differently in distinct body regions? Yan Li, Carlos Ibáñez, Meng Xie &co identify Gpc3 as a gene that selectively promotes the expansion of white adipose tissue in specific body areas in mice fed a high fat diet.
🧪 #metabolism #InMice
Why does #fat expand differently in distinct body regions? Yan Li, Carlos Ibáñez, Meng Xie &co identify Gpc3 as a gene that selectively promotes the expansion of white adipose tissue in specific body areas in mice fed a high fat diet.
🧪 #metabolism #InMice
In a new study, Yanzhu Fan, Guangzhan Fang &co show that glutamatergic projections from the substantia nigra pars reticulata to the dorsal raphe nucleus can regulate social rank and anxiety levels in male mice, adding to our knowledge of these important circuits.
🧪 #NeuroSky #InMice
In a new study, Yanzhu Fan, Guangzhan Fang &co show that glutamatergic projections from the substantia nigra pars reticulata to the dorsal raphe nucleus can regulate social rank and anxiety levels in male mice, adding to our knowledge of these important circuits.
🧪 #NeuroSky #InMice
In a new study, Yanzhu Fan, Guangzhan Fang &co show that glutamatergic projections from the substantia nigra pars reticulata to the dorsal raphe nucleus can regulate social rank and anxiety levels in male mice, adding to our knowledge of these important circuits.
🧪 #NeuroSky #InMice
Ischemic #stroke induces substantial neuronal remodeling. Huanhuan Chen, Ye Wei, Mikhail Spivakov, Oleg O Glebov &co find a loss of synapses in the ischemic core, but functional enhancement of synapses in the contralateral cortex in a mouse model of stroke.
🧪 #NeuroSky #InMice
Ischemic #stroke induces substantial neuronal remodeling. Huanhuan Chen, Ye Wei, Mikhail Spivakov, Oleg O Glebov &co find a loss of synapses in the ischemic core, but functional enhancement of synapses in the contralateral cortex in a mouse model of stroke.
🧪 #NeuroSky #InMice
Ischemic #stroke induces substantial neuronal remodeling. Huanhuan Chen, Ye Wei, Mikhail Spivakov, Oleg O Glebov &co find a loss of synapses in the ischemic core, but functional enhancement of synapses in the contralateral cortex in a mouse model of stroke.
🧪 #NeuroSky #InMice
#InMice so far
Graphical abstract
Researchers identify brain neurons responsible for building endurance after exercise #inmice. spkl.io/63322AtDPj
J. Nicholas Betley & colleagues
@cp-neuron.bsky.social
My child asked me why vaccines can't be delivered through sweat glands so he doesn't need a needle, so today's exciting science of the day is that, you can vaccinate against covid transdermally, including through sweat glands: www.nature.com/articles/s41...
( #inmice )
... IN MICE 🐭
jamesheathers.medium.com/in-mice-expl...
Vigtigt med retvisende overskrifter og passende forbehold for ekstrapolering til mennesker.
#JustSaysInMice #InMice #IMus
@adapalmer #InMice
#inMice but interesting
Voles speed up early cusp growth (a heterochronic shift), front-loading the process so more cusps develop quickly—like tooth development at 2x speed… unlike experiments #inmice, where you need to start cusp formation earlier to add more ⏲ (13/20)
Fluorescence microphotographs of developing mouse molars following treatments with molecules involved in tooth development. The combination of more treatments leads to more additional cusps. After Harjunmaa et al. 2012.
Experiments #inmice show how cusps form & what tricks can add more (spoiler: it’s hard). This gives us the #evodevo framework for how development could have shaped tooth evolution. **Somebody** just needed to get to work 🦷🧫💻 (6/20)
📷 Harjunmaa et al. 2012 www.doi.org/10.1038/nature10876
A “shield” that drastically reduces hay fever symptoms by applying antibodies to the nose via a vaccine-like nasal spray could be available within five years, scientists have said.
(£) www.thetimes.com/uk/science/a...
Good news if works out, but NB #InMice
Join us on June 18th (Training school) for Michael Tsoory lectures exploring traditional vs. home-cage-based behavioral assays in mouse models of mental disorders—through the lens of validity, reliability, and animal welfare.
#animalresearch #homecage #InMice @costprogramme.bsky.social
Yes, this is important, but also a very human journalist thing to do #inmice
#inmice should repost this. More science!
