Monogenic disorders of immunity: Common variants are not so rare While monogenic disorders of immunity typically involve rare alleles, some arise from alleles common in specific populations. Examples include IFNAR1/2 null alleles in the Arctic/Pacific and PTCRA hyp...

7/ 📖 Monogenic disorders of immunity: Common variants are not so rare
Cell Genomics (2025)
🔗 www.cell.com/cell-genomic...
#Immunology #HumanGenetics #InbornErrorsOfImmunity #IEI #Genomics #PopulationGenetics #PrecisionMedicine

Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...

💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...

January 26, 2026 - Duclaux Amphitheater – 9.20am – 6.00 pm An english in person symposium organised since 2015 by the Medical Direction dedicated to translational research.

🫀 How do we recreate organs in labs to study diseases?

Discover organoids research at Institut Pasteur

📅 Jan 26, 2026 | 9:20AM-6PM
📍 Paris | Free, registration required

Register: www.eventbrite.fr/e/translatio...

#Organoid #TranslationalResearch

Ancient Romans Guarding Hadrian’s Wall Were Riddled with Worms and Parasites Romans living in ancient Britain were plagued by intestinal parasites, all of which are spread by fecal contamination

Hadrian’s Wall meets Montezuma’s Revenge.

New preprint from our lab, spearheaded by @maelledaunesse.bsky.social and in collaboration with Diego Villar!

In which we ask, can we detect joint signatures suggestive of positive selection on transcriptomes and epigenomes?

Photo de groupe des 60 Pasteuriens sur la ligne de départ des 20km de Paris ce dimanche 12 octobre.

🏃‍♂️ 60 Pasteuriens sur la ligne de départ des 20km de Paris ce dimanche !

Depuis 17 ans, ils courent pour porter les valeurs de la recherche : persévérance, engagement, dépassement de soi.

#20kmDeParis #Pasteurdon

Early Life Immune Development and Function   - IMMUNOLOGY2026™ Time: 8:00 - 11:30 AM Chairs: Chrysothemis C. Brown, Memorial Sloan Kettering Cancer Ctr., USA Petter Brodin, Imperial Col. London and Karolinska Inst., GBR, SWE

The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...

Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E‐selectin Background The ABO blood group system is associated with differential susceptibility to thrombotic vascular diseases. ABO is also known to be a strong trans-protein quantitative trait locus for plas...

Our latest study explains the link between the ABO blood type and its known associated differential susceptibility to thrombotic vascular diseases:
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social

Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.

What we need now, more torpor. I got a fever, and the only cure is more torpor. A synthetic torpor-like state, induced by ultrasound, to be precise. www.nature.com/articles/s42... 2

Molecular basis of autoimmune disease protection by MDA5 variants Loss-of-function MDA5 variants increase the risk of chronic inflammation but protect against autoimmune disease. Singh et al. show that autoimmune-protective variants impair MDA5 signaling via differe...

Good fun to contribute to this super paper from Yorgo Modis' lab where we looked at the impact of disease-associated MDA5 mutations on its structure, biochemistry and antiviral functions #immunosky www.cell.com/cell-reports...

Steroid hormone levels vary with age, sex ... and lifestyle A large-scale ten-year study conducted by the Institut Pasteur on a thousand individuals has shed new light on steroid hormones. Levels of these molecules, which play a crucial role in our health, var...

Steroid hormone levels vary with age, sex ... and lifestyle. A large-scale ten-year study conducted by @milieuinterieur.bsky.social on a thousand individuals has shed new light on #steroid hormones. ↘️

Poster for EFIS sex Differences in Immunity Congress on 23 October at Institut Pasteur Paris

Join the 1st EFIS Sex Differences in Immunity Congress – October 23, 2025 @pasteur.fr @sexdiffimmunity.bsky.social Registration link lnkd.in/emerimQc abstracts welcome from all researchers, scientists, clinicians #immunosky

Delighted to have taken part in this project that was published today led by Tomas Ryan’s lab @tjryan.bsky.social @tcddublin.bsky.social @tbsi-tcd.bsky.social ….. mice remember cold 🐭📝❄️

Our second online seminar will take place next week:

🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online

Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...

A study published in Science advances, from @milieuinterieur.bsky.social consortium and led by @darraghduffy.bsky.social & @immunobladder.bsky.social, describes 17 #steroid hormone variability and associations with several lifestyle choices, aging, sex, genetics
institutcochin.fr/en/actualite...

Steroid hormone levels vary with sex, aging, lifestyle, and genetics

New Milieu Intérieur study describing the causes of steroid hormone variability and associations with health & disease lead by @jamiesugrue.bsky.social Elizabeth Maloney & Léa Deltourbe between teams of @darraghduffy.bsky.social & @immunobladder.bsky.social www.science.org/doi/10.1126/...

Our new study quantifies sex steroid hormone changes with age in women & men, with strong impact of genetics, contraception, smoking, BMI & lifestyle often in sex specific ways @immunobladder.bsky.social @milieuinterieur.bsky.social @pasteur.fr
🧪#immunosky #medsky www.science.org/doi/epdf/10....

Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences

register.gotowebinar.com/register/822...

The EFIS Sex Differences in Immunity group is organising a small congress this fall. We want to make it free to facilitate access. But we need to evaluate attendance interest. We kindly ask you to fill in this form if you would be interested in attending.
forms.office.com/e/2cEmKbVurx

📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !

Being at @pasteur.fr has its perks sometimes

Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness Mammary intraepithelial lymphocytes enhance mammary gland differentiation during pregnancy, thereby promoting offspring fitness.

Now available online: our recent work showing that the maternal adaptive immune system promotes optimal lactogenesis. @dancrrl.bsky.social
www.cell.com/cell/fulltex...

What Makes Us React Differently to Viruses? | My PhD at the Institut Pasteur – Yann Aquino YouTube video by Institut Pasteur EDUCATION

🔬 What Makes Us React Differently to Viruses? #MyPhDAtTheInstitutPasteur

This is the question Yann Aquino explored in his PhD at the Institut Pasteur & how factors like genetics and environment shape the response to infection by viruses like SARS-CoV-2.

Read his thesis 👉 bit.ly/YAPhD
@pasteur.fr

True joy as we enter week two of vacances scolaire. ie. A palatable morning metro journey

Happy first day of Spring to all the Imbolc pagans out there. Paris clearly got the message