Very positive spin on #GenerativeAI tools from @nature.com:
www.nature.com/articles/d41...
New to me is @thesify.bsky.social - anyone had any experience using this?
I'm trying to understand the privacy policy re: how inputs (papers, grants) are protected & whether they are used for training AI?
vimeo.com/1037419193?s...
We are chronically short of blood donors. Please watch Yaseen’s story to help understand how important blood donation is.
ICIs can alter atherosclerotic plaques immune landscape, fascinating and salient insight into the potential long-term 'collateral damage' from these drugs, particularly important as their use in the neo/adjuvant settings rapidly expands www.nature.com/articles/s44...
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📑 What a comprehensive review! 👏
ICIs have come so far - so many combinatorial strategies. Rational/precision tx & biomarkers remain areas of unmet need. Will AI/ML 🤖 help? So much more to do.
Hopefully our #MANIFEST project (manifest-io.org.uk) can also contribute to this in the coming years.
🎨 In case anyone need…
The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏!
Check it out 👇
bioart.niaid.nih.gov
📌 Thanks!
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Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...
After months in the making, super excited about the official launch of MANIFEST (www.manifest-io.org.uk) 🚀, led by the visionary Samra Turajlic.
Happy to be a co-investigator & delivering parts of the programme as #TeamManchester: UoM, CRUK MI, CRUK NBC & #TheChristie.
Let's get started! 🙌
A couple of days left to apply! We have a PhD position available in the lab to improve our understanding of cfDNA and cfRNA shedding from cancer cells, and the potential impact on heterogeneity. #cfDNA #liquidbiopsy #cfRNA
Before I go to bed let me post an amazing paper by Filipe Pereira’s group (Ervin Ascic et al) for your enjoyment. I think this is a likely fundamental breakthrough in cancer immunotherapy: personalized, yet generic and probably pan-cancer. www.science.org/doi/10.1126/...
Thanks so much for putting this together!
Here's the #Cancer #Research #2 starter pack 🤩
Researchers, oncologists, patient advocates & more -working across all aspects of cancer research and treatment 🧪🔬⚕️
I also tried to give some exposure to #PhD #students & #postdocs - randomly picked from followers of me or my lab!
go.bsky.app/6EcjWNA
Fascinating read and salient illustrationsof the limitations/dangers of implementing machine learning into clinical decision making. As clinicians we shouldn't be deterred from trying to look inside the 'black box' and understand potential unforeseen consequences. www.aisnakeoil.com/p/does-the-u...
#ScienceSaturday How can we enhance CAR-T cell activity against solid cancers?
➡️ In a recent study, Zhao et al transduced CAR-T to express IL-10, resulting in enhanced T-cell proliferation, effector function, mitochondrial capacity and antitumor activity in a variety of solid tumor murine models.
Well this is all rather pleasant and civilised isn't it...