1/ 🔬🧑‍💻 Tired of going back and forth between GUIs and code for your 3D image analysis needs? Would you like to keep your focus in one place (notebook), without sacrificing interactivity? Here’s a tool that can help!

A panel of immunohistochemistry images showing infection of a panel of IAV viruses (as 6:2 reassortants on a PR8 backbone) in epithelia from the teat and gland cisterns of Aberdeen Angus, Limousin and Holstein Friesian cattle

🚨New pre-print!🚨
Using a panel of different H5N1 clade 2.3.4.4b viruses and human seasonal influenza, and mammary explants from common beef and dairy cattle breeds, we add to the growing data showing that H5N1 spillovers into cattle should be seen as an ongoing risk
www.biorxiv.org/content/10.6...

I was just joking about how I missed out on a lot of great things and opportunities yesterday… this just tops it off, but glad it’s now a thing in the UK again

Somatic mutations in autoimmune lymphocytes may allow them to escape tolerance constraints through a polyclonal cascade of somatic evolution @nature.com @sangerinstitute.bsky.social @ims-mrl.bsky.social @cuh.nhs.uk @imartincorena.bsky.social
www.nature.com/articles/s41...

I start to realise how perfect music is as a medium for memories, now it pains me that I could no longer listen to a lot on my playlists when I think or write... since most of them just reminds me of a series of past events...
Slowly developing a love for jazz, anything else that would help?

Macrophages self-generate and refine chemotactic gradients during migration towards complement C5a Macrophages don’t just follow chemoattractants to locate sites of infection, they can also create and sculpt them as guidance cues but the mechanisms remain unclear. This study shows that macrophages ...

New paper! Self-generated gradients in macrophage chemotaxis. Just published, by the esteemed Abhi Kiran and many collaborators.
A short skytorial follows.

journals.plos.org/plosbiology/...

📣We've summarized all there is to know about mouse #gdTcells in cancer and how they relate to humans
@immunowolf.bsky.social #AbhiramMallu #NataliePhinney
check it out here:
authors.elsevier.com/sd/article/S...

Excited to share our latest work lead by Fred Fercoq and Gemma Cairns. Huge thanks to @breastcancernow.bsky.social and amazing colleagues for making it possible. www.cell.com/cell-reports...

The cinematography of Sinners was absolutely incredible, also the reason I’d say it’s my film of year. I’m glad she won and she absolutely deserves this win.

Very nice review but I have to complain about the plain text summary, it’s plain text indeed, but somehow reads very tiresome, my brain just hurts reading it

While expansion is comparable, activation and differentiation of T cells diverges between CD3/CD28 beads versus soluble antibody complexes
www.nature.com/articles/s41...

HIF-1α+ CD4+ T cells coordinate a tissue-resident immune cell network in the lung Tertiary lymphoid structures are critical components of tissue immunity, necessitating better understanding of their organization and immune functions. De Lima et al. investigate the spatial and tempo...

Excited to share our work published in @cp-immunity.bsky.social! We investigated the role of HIF-1α in CD4 T cells using #Xenium spatial transcriptomics in infected lungs containing #TertiaryLymphoidStructures (TLS) (1/10).

www.cell.com/immunity/ful...

Vγ1 γδ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model In lung cancer, airway macrophages are modulated by an unconventional T cell subset, relevant to care for pulmonary comorbidities.

Delighted to share our latest paper, led by Dr Ximena Raffo-Iraolagoitia, just published in Science Advances! www.science.org/doi/10.1126/...

Colonic Engyodontium fungus triggers neutrophil antimicrobial activity to suppress Lactobacillus johnsonii-derived glutamic acid-maintained Tregs
www.jci.org/articles/vie...
@jci.org

Lymph nodes, can’t remember what the red stained for…

Impressive… My hands often shake badly whenever I try to take pictures from the eyepiece, usually had to take several pics in a row just to get one good picture with perfect angle…

📣Register now for the Beatson International Cancer Conference 2026 ‘From Tumour Genesis to Metastasis: an immune perspective’

📅22-25 June 2026
📍CRUK Scotland Institute, Glasgow
🎟️Early Bird registration closes on 1 April
🔗 www.beatsonconference.org

#BICC2026 #CancerResearch #Immunology

Tissue Regulatory T Cells FOXP3+ regulatory T cells (Tregs) have well-defined roles in limiting systemic immune responses against diverse stimuli. However, the observation that a subset of Tregs also enter nonlymphoid tissues,...

Our latest review is out, a comprehensive synthesis of #tissue #Tregs. It has been a decade since @annualreviews.bsky.social #immunology last reviewed #TissueTregs, and there have been enormous advances and conceptual leaps forward in the field

www.annualreviews.org/content/jour...

A data figure showing a phylogenetic tree of H3N2 with 2025-K highlighted, the structure of the HA trimer with mutations characteristic of K highlighted, and box and whisker plots showing % neutralisation of the 2022 H3N2 vaccine strain, and of 2025 clade K, by various human antisera

🚨New Pre-Print🚨
Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity
www.medrxiv.org/content/10.6...

Our new book "Self-Doubt" is written by scientists for scientists. You might think you are alone when you doubt your ability or suitability for science - you aren't. We all question ourselves and carry doubt with us daily.

www.amazon.co.uk/Self-Doubt-A...

RNA-binding proteins and ribonucleoproteins as determinants of immunity - Nature Reviews Immunology RNA-binding proteins (RBPs) considerably expand the information content of the genome and can determine the lifespan, localization and function of RNA, thereby controlling when, where and how much pro...

Just out @natrevimmunol.nature.com
RNA-binding proteins and ribonucleoproteins as determinants of immunity
www.nature.com/articles/s41...
gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.

🚨 Deadline approaching! Last chance to present your work at #SIGNET26.

Abstract submissions close this Thursday, 29 January, with oral presentation slots reserved for postdocs and PhD students, plus poster prizes.

🔗 https://bit.ly/49VL6FA

Quite like the “watermark” in the cell membrane, should make these into a calendar… I’d definitely pick up a few.

We are delighted to announce that @mitosrus.bsky.social from @cruk-si.bsky.social @glasgow.ac.uk has been awarded the 2026 Hooke Medal

You can read about Stephen's work on mitochondria, cell death and cancer here:

bscb.org/hooke-medal-...

Finally, my PhD project is published! 🎉

I am thankful to all the collaborators who made this possible!

www.nature.com/articles/s41...

@natcomms.nature.com
#dendriticcells #immunesynapse #centrosome

🤯

New research news! Supercharging immune cells could provide an effective way to tackle cancer #CancerResearch www.gla.ac.uk/news/headlin...

An atypical low stiffness epithelial-to-mesenchymal transition state that prevents immune cell-mediated killing of dormant metastatic lung adenocarcinoma
@natcancer.nature.com @mskcancercenter.bsky.social
www.nature.com/articles/s43...
www.nature.com/articles/s43... @cedric-blanpain.bsky.social

Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors - Nature Biomedical Engineering This study shows that T cell cross-reactivity is influenced by the co-signalling molecules CD5, CD8 and CD4, and that cytotoxic T cells with a CD8→CD4 co-receptor switch show reduced cross-reactivity ...

🚀 Our new Publication in Nature Biomedical Engineering!🎉

📄 Title: Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors

🔗 Read the full paper here: www.nature.com/articles/s41...

Happy new year!!

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease - Nature Immunology Here the authors show that persistent antigen stimulation drives the generation of CD8+ tissue-resident exhausted T cells with distinct developmental origins, function and therapeutic responsiveness w...

'The presence of CD8+ T cells coexpressing residency and exhaustion molecules in chronic diseases often correlate with clinical outcomes; however, the relationship between these cells and conventional tissue-resident memory (TRM) cells or exhausted CD8+ T (TEX) cells is unclear.'
#Immunology