Exonic enhancers are a widespread class of dual-function regulatory elements www.biorxiv.org/content/10.1101/2025.03....

Exonic enhancers are a widespread class of dual-function regulatory elements Exonic enhancers (EEs) occupy an under-appreciated niche in gene regulation. By integrating transcription factor binding, chromatin accessibility, and high-throughput enhancer-reporter assays, we demo...

Preprint here: www.biorxiv.org/content/10.1...

Thousands of exons carry enhancer activity. We validate EEs with STARR-seq, luciferase assays, and CRISPRi, and show disease relevance via TCGA and GWAS data.
A paradigm shift in how we interpret coding regions!
#FunctionalElements #ExonsAsEnhancers

Exons can regulate genes too!
Our new work shows that many coding exons are also enhancers, identified across species, and diseases. These exonic enhancers (EEs) can modulate gene expression and present regulatory variants.
#ExonEnhancers #BioRxiv #FunctionalGenomics

Exons ≠ just protein code. We identify 13,000+ exonic enhancers in humans and show their regulatory activity with ChIP-seq, STARR-seq, and CRISPRi.
Mutations in EEs impact expression & patient survival in cancer.
#DualFunctionDNA #CancerGenomics #cisRegulation

Exonic enhancers are a widespread class of dual-function regulatory elements Exonic enhancers (EEs) occupy an under-appreciated niche in gene regulation. By integrating transcription factor binding, chromatin accessibility, and high-throughput enhancer-reporter assays, we demo...

Just out on bioRxiv!
Our latest study uncovers a widespread class of dual-function elements: Exonic Enhancers (EEs) — coding sequences that also act as cis-regulatory enhancers.
Check it out 👉 www.biorxiv.org/content/10.1...
#Genomics #GeneRegulation #Enhancers #ExonEnhancers

respect!

I had a great time presenting at the Institut Français de Bioinformatique (IFB) / ELIXIR France annual meeting! Got valuable feedback during my talk ! I’m optimistic about the support for the ReMap resource from the IFB and look forward to the collaborations ahead !

🌟 "I am the ReMap guy…" 🌟
ReMap is your go-to ChIP-seq database, mapping TFs, co-factors & chromatin regulators across genomes. High-res, open-access binding landscapes for human, mouse & more. Ready to explore gene regulation?
🧬 remap.univ-amu.fr
#Genomics #Bioinformatics #ChIPseq