Nutrient requirements of organ-specific metastasis in breast cancer - Nature How the complex interplay between multiple nutrients within the microenvironment dictates potential sites of metastatic cancer growth is explored.

www.nature.com/articles/s41...

congrats to the @mvhlab.bsky.social !!

The value of publishing negative data - News Scientific journals love news-worthy results. Editors want to publish studies with novel data that scientists will eagerly read and cite in their own work. Because of this desire for novelty, studies ...

Giving the gift of negative data 🥰

Since I joined @lsajournal.org I have handled several stellar manuscripts that report null results. These papers do very well and reviewers almost always appreciate them!

Thanks @rockefeller.edu news team for the article!

www.rockefeller.edu/news/38829-t...

TAD boundary architecture and gene activity are uncoupled Topologically associating domains (TADs) are prominent features of genome organization. A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD...

"We find that while TAD boundaries pair more frequently than non-boundary regions, these interactions are infrequent and are uncorrelated with transcriptional activity of genes within the TAD. (...) These results suggest that TAD boundary architecture and gene activity are largely uncoupled"

I'm thrilled to host @lindsaylafave.bsky.social at Loyola today! She gave an incredible talk describing chromatin biology throughout lung cancer progression!

Comparative characterization of OncoPro and Wnt-Based media reveals distinct phenotypic and pharmacologic states in patient-derived tumor organoids www.biorxiv.org/content/10.64898/2025.12...

A spatial atlas of colorectal cancer reveals the influence of stromal niches on tumour differentiation www.biorxiv.org/content/10.64898/2025.12...

Cellular states associated with metastatic organotropism and survival in patients with pancreatic ductal adenocarcinoma - Nature Genetics Integrated clinical and single-cell analysis of primary pancreatic tumor samples that later recur in the liver or lung shows that tumor cells at the primary site transcriptionally resemble the normal ...

www.nature.com/articles/s41...

Primary tumor chromatin landscape governs metastatic organotropism - Nature Cancer Little is known about how mutations in genes encoding tumor suppressors influence metastatic site selection and whether sustained inactivation of such genes influences tumor maintenance at these sites...

Many thanks to #AmyGladstein & #DavidFeldser for this great perspective on our recent paper @natcancer.nature.com. As they say in it (and have elegantly shown in their work): "‘Flip the switch’ and let nature show you the way!" 🔦🧬🐭
www.nature.com/articles/s43...

G&D will be at Biology of Cancer 2025 #cshlcancer this week. Come find us in Grace Lobby or schedule an appointment below if you'd like to chat about your work or learn more about publishing with us.

@cshlmeetings.bsky.social @genesdev.bsky.social

➡️ https://tinyurl.com/GenesDev-MeetTheEditors

Positive Selection Screen for Natural Product β-Catenin Inactivators www.biorxiv.org/content/10.1101/2025.08....

🚨Excited for the 2nd MRS Early Career Research Virtual Meeting on Nov 18-19, 2025!

Trainees & Junior Faculty (within 3 years of starting your lab), share your work!
Abstract Deadline: Sept 12, 2025. Submit here: bit.ly/47KLyp2

❗Free registration for MRS Members! #MRS #Research #EarlyCareer

Induction of a mismatch repair deficient genotype by tailored chemical mutagenesis in experimental models of cancer Mismatch repair deficient (MMRd) tumors harbor thousands of somatic mutations enriched for insertion–deletion (indels) conferring high sensitivity to …

This is an important milestone: mutagenic drugs can increase TMB and induce a dMMR-like genetic profile, but do not improve response to immunotherapy in pMMR CRC patients. Some evidence of TIME remodelling, but likely not in the direction needed fro response... www.sciencedirect.com/science/arti...

Epithelial-to-mesenchymal transition (EMT) and cancer metastasis: the status quo of methods and experimental models 2025 - Molecular Cancer Epithelial-to-mesenchymal transition (EMT) is a crucial cellular process for embryogenesis, wound healing, and cancer progression. It involves a shift in cell interactions, leading to the detachment o...

link.springer.com/article/10.1...

Loss of colonic fidelity enables multilineage plasticity and metastasis - Nature The chromatin-remodelling enzyme ATRX and the transcription factor HNF4A are identified as pivotal regulators of colonic epithelial identity, with roles in metastasis in colorectal cancer.

Check out this elegant paper by Kevin Myant and team implicating ATRX mutations and loss of colon identity in #plasticity and #metastasis 👇@nature.com @edinburgh-uni.bsky.social‬
www.nature.com/articles/s41...

Evolutionary paths towards metastasis - Nature Reviews Cancer In this Perspective, Kamila Naxerova discusses how genetic analyses of primary tumours and matched metastases can distinguish between competing metastasis evolution models, arguing that further insights into human metastasis biology could be enabled by a framework that rigorously quantifies whether metastases descend from a nonrandom selection of primary tumour lineages.

🚨 PERSEPCTIVE

Naxerova explains how genetic analysis of primary tumors & metastases can distinguish competing metastasis models, arguing that quantifying whether metastasis occurs through nonrandom lineage selection could offer insights into metastasis biology.

📖 👇

PCSK9 drives sterol-dependent metastatic organ choice in pancreatic cancer - Nature PCSK9 regulates low density lipoprotein-cholesterol import and determines organ preference of metastatic pancreatic ductal adenocarcinoma, with PCSK9-low cells metastasizing to the liver and PCSK9-hig...

new out in Nature today www.nature.com/articles/s41...

Fishing for melanoma metastasis-initiating cells in lymph nodes Nature Cancer - The complex nature of metastasis-initiating cells (MICs) has long hindered our understanding of how cancer spreads and how to prevent it. A study now identifies a potential MIC...

rdcu.be/emi9N
Fishing for Metastasis Initiating Cells (MICs): we summarize here a heroic effort from Christoph Klein and Melanie Werner-Klein labs, which describes a MIC population in lymph nodes and how these cells evade immune attack. #metastasis #melanoma #extracellularvesicles #cancerprevention

#AACR25

The size of the plenary hall is always inspiring. So many cancer researchers in one place!

Fantastic talk by @karunamdphd.bsky.social! A comprehensive study investigating microenvironmental impact on young onset colorectal cancer.

Ready to learn about dormancy at #AACR25

Tumor metabolism is always a tough topic but the speakers at the microenvironment and metabolism session at #AACR25 are doing a great job making it accessible.

While many nutrients are absent in the area around the tumor. Some metabolites are far more abundant! How are tumors using these instead?

Fantastic first session at #AACR25 on non-genetic drivers of metastasis!

While genetic drivers are important in establishing fitness, it is clear that they are not sufficient to lead to metastasis by themselves.

Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes Most phenotype-associated genetic variants map to noncoding regulatory regions of the human genome, but their mechanisms remain elusive in most cases. We developed a highly efficient strategy, Perturb...

Out today in @science.org!
What if you could chart cells' regulatory programs at unprecedented resolution?
In my work with Jorge Martin-Rufino from the @bloodgenes.bsky.social lab, we dissect the genome’s control circuits and find where key genetic variation hides
bit.ly/3YhBMoO

Regulation of metastatic organotropism Metastasis is responsible for most cancer-related deaths. Different cancers have their own preferential sites of metastases, a phenomenon termed metastatic organotropism. The mechanisms underlying org...

Super nice review on metastasis organo-tropism⬇️ the process where tumor cells preferentially spread to specific distant organs, and represents a critical aspect of cancer biology with profound implications for patient outcomes. #CDH1
www.cell.com/trends/cance...

Figure 1 TFBomics of the E11.5 mouse embryo. (A) Schematic overview of the experimental design, detailing the tissues dissected from E11.5 JAX/Swiss mice and the targets profiled in each tissue using C&R LoV-U. (B) Left: Clustering of data according to Spearman's correlation. Black boxes highlight higher correlation or clustering according to the profiled factor, whereas red boxes highlight this between factors within the same tissue. IgG negative controls are highlighted in a gray box. Right: Overall data patterns shown by PCA. PC1 (58.7% of variance) separated some samples by the target factor (ellipses shaded by factor color code), while PC2 (9.7% of variance) typically separates the liver (marked with stars) from other tissues.

Construction of an atlas of transcription factor binding during mouse development identifies popular regulatory regions

Read this Techniques & Resources Article by @annanordin.bsky.social @gianlucazamba.bsky.social @claudiocantu81.bsky.social & co.: doi.org/10.1242/dev....

Decoding gene regulation with CRISPR perturbations - Nature Biotechnology Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks.

Two CRISPR tools for combinatorial genetic perturbations reveal gene regulatory networks #NBTNV go.nature.com/3WOWHjb
rdcu.be/dItUy

Human-correlated genetic models identify precision therapy for liver cancer - Nature As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in ...

Out in Nature today: A suite of GEMMs recapitulating the spectrum of human Liver Cancer phenotypes, showing once again that a little MYC goes a long way
www.nature.com/articles/s41...

Cancer-Associated Fibroblasts Serve as Decoys to Suppress NK Cell Anti-Cancer Cytotoxicity in Breast Cancer - by Aviad Ben Shmuel, Yael Gruper, Coral Halperin, Ruth Scherz-Shouval and colleagues doi.org/10.1158/2159...

Ten simple rules for writing a response to reviewers

journals.plos.org/ploscompbiol...