Tissue organization is fundamental to how tissues function - yet in cancer such spatial patterns can progressively break down. Ever wondered how?!

Check out our new study, where we investigate how lymphoma reshapes lymph node architecture 👀

Advancing CNS tumor diagnostics with expanded DNA methylation-based classification Sill and colleagues present an expanded DNA methylation classifier for CNS tumors. Building upon the 2021 WHO classification, this resource introduces a hierarchical taxonomy of 184 subclasses. It enhances classification accuracy for rare entities and provides integrated genomic data from a single, streamlined assay for modern neuro-oncology.

Online Now: Advancing CNS tumor diagnostics with expanded DNA methylation-based classification

Join us:

With @abigailsuwala.bsky.social we are looking for a postdoc to drive our spatial transcriptomics analysis efforts of brain tumours.

If you enjoy multidisciplinary biomedical research, big data and coding, you are in the right place.

karriere.klinikum.uni-heidelberg.de/index.php?ac...

Congratulations to Felix Sahm, recipient of the #EANO Research Award 2025!
This award recognises his outstanding contributions to basic, translational, and clinical research in #NeuroOncology and #Neuropathology.

#EANO2025 #ResearchExcellence
@dkfz.bsky.social

Next up- Erik Oermann talking about the practical aspects of data storage and organisation, structuring data to be able to train/deploy LLMs.

Starting off with Daniel Orringer discussing a very important topic- how to integrate molecular data streams coming from Raman, Nanopore-seq, etc intraoperatively.

At the Congress of Neurological Surgeons #2025CNS 🧠 in sunny LA this weekend ☀️

A spatial transcriptomics analysis led by my student Zaira reveals the distinct nature (gene expression, tumour cell states and local microenvironments) of radionecrosis and recurrence in glioblastoma. 👏

🚨 new glioblastoma preprint alert!

we present the first spatially resolved single cell atlas comparing radionecrotic changes (RN) and recurrent IDH-wildtype glioblastoma (GB) –– shedding light on a long-standing diagnostic challenge.

🧵 1/

What if you could get a glimpse of the future of your health, today?

Our scientists have developed a new generative AI model, trained using large-scale health records, that can estimate how human health may change over time.

Watch to find out more.

🖥️🧬

This is figure 4, which shows explainable AI offers insights into disease progression.

A paper in Nature presents a new artificial intelligence model that can predict how a person’s health might change over their lifetime. This tool could help doctors and health planners to better understand and prepare for personalized medical needs. go.nature.com/4n6giWi #medsky 🧪

Advancing sarcoma diagnostics with expanded DNA methylation-based classification www.medrxiv.org/content/10.1101/2025.06....

🧠 June 8 is #WorldBrainTumorDay — raising awareness & understanding of brain tumors.
EANO supports progress in #NeuroOncology through research, education & collaboration.
🔗 Learn more: www.eano.eu
#btsm #BrainTumor #Oncology

Alliance und BioRN im Stuttgarter Landtag Inspirierender Austausch mit Parlamentarier:innen zum Innovationscampus Health + Life Science Alliance Heidelberg I Mannheim Unter dem Motto "Zukunft Innovationsstandort Baden-Württemberg: Life Scienc...

Yesterday we had the pleasure of informing our Baden-Württemberg government about the future of biomedical #innovation in Heidelberg/Mannheim.
Thanks to everyone who helped to make this a successful event @michaelboutros.bsky.social @biorncluster.bsky.social
The article is published in German only.

🧠 Thank you for joining the #EANOYoungsters Journal Club!
Over 200 attendees from around the world joined us to discuss CNS tumor profiling (Patel et al., Nat Med, 2025).

▶️ Missed it? Watch the recording soon on our YouTube: www.youtube.com/@eano_associ...
#NeuroOncology #CNScancer

🧠 Join the next #EANOYoungsters Journal Club on June 5, 16:30–17:30 CEST!
Discussing: "Rapid molecular profiling of CNS tumors" www.nature.com/articles/s41... (Patel et al., Nat Med 2025)
📍Free & open to all EANO members
🔗 www.eano.eu
#NeuroOncology #BrainTumors #JournalClub

The organizing committee of the UNITE conference would like to thank all speakers for their excellent presentations and all participants for the valuable discussions. @wickwolfgang.bsky.social @michael-platten.bsky.social

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...

🧠 A recent publication in Nature Medicine covers the prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.
🔗 Learn more: doi.org/10.1038/s415...
#MalignantBrainTumor #NeuroOncology #BrainTumors #EANOessentials

Many thanks to all authors for their collaboration and support!

Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors - Nature Medicine Application of a nanopore sequencing workflow for real-time analysis of brain tumors results in molecular classification within a 30-minute intraoperative window, followed by comprehensive profiling w...

Kicking off my BlueSky account with a 🚨 new paper alert!!

Thrilled to share that my final PhD paper is now out in Nature Medicine @natmedicine.bsky.social 🎉

🔗 www.nature.com/articles/s41...

#MethylationClassification #MolecularDiagnostics #CNSTumours #NanoporeSequencing

Population-scale analysis of inheritance patterns across 858,635 individuals reveals recent historical migration patterns across the North Sea from the Middle Ages to the Industrial Revolution The North Sea's historical migrations have impacted the genetic structure of its neighbouring populations. We analysed haplotype sharing among 858,635 modern individuals from Denmark and Britain to in...

New Preprint klaxon - and calling all Danes+Brits who are interested in genetics+history - a new preprint led by Xiaolei Zhang in my group with Soren Brunak's group about genetic exchange from 1100 to the present day between UK (Britain)+Denmark. Read on for details www.biorxiv.org/content/10.1...

Spatial transcriptomics holds great promise to understand biological tissue function, but the assignment of transcripts to cells has been a substantial bottleneck.

For this reason, Elyas Heidari, a student in my lab and in @steglelab.bsky.social built segger.

www.biorxiv.org/content/10.1...

Segger logo

Message passing intuition behind the segger’s link-prediction model and the network architecture

1/ New preprint! 🍳

@elihei.bsky.social and our team at @embl.org , @dkfz.bsky.social, and @mskcancercenter.bsky.social built #segger - a fast, accurate cell segmentation tool for spatial transcriptomics that assigns transcripts to their cell origins!

doi.org/10.1101/2025...

Great to be visiting @nanoporetech.com as part of a cns Nanopore symposium meeting with pathologists and clinical scientists to discuss the application of nanopore sequencing in the clinic.

cIMPACT-NOW update 9: Recommendations on utilization of genome-wide DNA methylation profiling for central nervous system tumor diagnostics Abstract. Genome-wide DNA methylation signatures correlate with and distinguish central nervous system (CNS) tumor types. Since the publication of the init

A new open access article: cIMPACT-NOW update 9 – recommendations on genome-wide DNA methylation profiling for CNS tumor diagnostics – is now available in Neuro Oncology Advances 🔗 academic.oup.com/noa/article/... 🔓 #EANOessentials #NeuroOncology #MalignantBrainTumor

IDH-mutant astrocytomas with primitive neuronal component have a distinct methylation profile and a higher risk of leptomeningeal spread - Acta Neuropathologica IDH-mutant astrocytomas are diffuse gliomas that are defined by characteristic mutations in IDH1 or IDH2 and do not have complete 1p/19q co-deletion. The established grading criteria include histologi...

New paper alert! We’ve identified a distinct subset of IDH-mutant astrocytomas harboring a primitive neuronal component.

A big shoutout to Felix Hinz, Niek Maas and to the entire team for their incredible effort!

link.springer.com/article/10.1...

Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen - Nature Communications Vaccination in glioblastomas does lead to the emergence of tumour-antigen-specific T cells but T cell dysfunction, poor tumour infiltration and persistence hinder efficient tumour killing. Here author...

1/2 Super excited to see this finally out @naturecomms.bsky.social ! We developed an off-the-shelf T cell receptor T cell therapy for patients with glioblastoma from a peptide vaccinated patient. Looking very much forward to its translation within DKTK supported by HI-TRON!

Computational with a PhD in some quantiative science, and want to make the world a better place with AI in healthcare? Want to work with some of the most innovative AI groups in the life sciences? Want to work for Europe, across Cambridge and Heidelberg, living in the UK? Two more days to apply: