Highlights from late-breaking @TheLancet at #ESCMIDGlobal2026 📊
🔹 WGS + AI for RR-TB → better outcomes
🔹 UTI → nitrofurantoin best; fosfomycin worst
🔹 H5 immunity → partial cross-protection
🔹 M. pneumoniae CAP → steroids speed recovery
🚀 Precision + smarter antimicrobial use are shaping ID
Key take-home at #ESCMIDGlobal2026:
🧬 Partial cross-reactive immunity to H5 exists
💉 Likely from prior seasonal influenza exposure
⚠️ May not prevent infection—but could blunt severity
👉 Population not fully naïve to H5N1 👀
New data at #ESCMIDGlobal2026:
🧬 Functional N1 antibodies detected against both seasonal & avian influenza
🔗 Strong correlation between responses
💉 Likely driven by prior H1N1 exposure (infection or vaccination)
👉 Population may be less immunologically naïve than assumed
H5 spillover is increasing—but the key question is immunity.
🦠 Frequent spillover: poultry → mammals → humans (no sustained transmission)
⚠️ Pandemic risk hinges on spread in an immunologically naïve population
👉 Are we more vulnerable than we think? #ESCMIDGlobal2026
H5 avian influenza at #ESCMIDGlobal2026:
🦠 Expanding host range → birds, mammals (incl. cattle), occasional human cases
🌍 Now across 6 continents with rising spillover
⚠️ Pandemic risk = spread in an immunologically naïve population
No sustained human transmission—yet 👀
Next Up! at #ESCMIDGlobal2026:
🦠 Population immunity to highly pathogenic avian influenza (H5) in healthcare workers
Early insights into immune responses—and what this means for exposure risk and pandemic preparedness 👀
#Lancet
Being presented tomorrow afternoon at #ESCMIDGlobal2026 as part of the Lancet session (Hall A3-1):
Characterisation of immune responses targeting highly pathogenic avian #influenza A(H5) viruses in health-care workers in the Netherlands
www.thelancet.com/journals/lan...
New Research, oral presentation, Lancet Late Breaker session, #ESCMIDGlobal2026, 20 April
Maribavir for clinically significant cytomegalovirus infection in haematopoietic cell transplant recipients in Europe: a real-world multicentre retrospective registry study
www.thelancet.com/journals/lan...
Promotional card. Contact Stephanie Becker regarding content enquiries at stephanie.becker@lancet.com. Copyright: Elsevier Ltd.
Stephanie Becker, Senior Editor, welcomes queries from #ESCMIDGlobal2026 attendees. Our journals are committed to supporting you on every stage of your publication journey. Learn more about our scope and global reach & impact here: hubs.li/Q03BLcyV0
@escmid.bsky.social
The May issue of @lancetgastrohep.bsky.social is out now at www.thelancet.com/gastrohep!
Content this month includes #colorectalsurgery, #colorectalcancer, #viralhepatitis + more
#GastroSky #MedSky #LiverSky #HepSky
New research article
Characterisation of immune responses targeting highly pathogenic avian #influenza A(H5) viruses in health-care workers in the Netherlands: an observational, cross-sectional analysis
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #ViroSky #OpenAccess #OA
The April 2026 issue of The Lancet Regional Health - Americas is now available online!
lnkd.in/gcRM-wYU
In this issue: #USDietaryGuidelines, #NosocomialInfections, #LongCOVID, #OropoucheVirus, #RenalCellCarcinoma, #ColorectalCancer, #LungCancer, #YellowFever, #OpioidUseDisorder, and much more.
Enhance your clinical knowledge today through patient case studies, graphical summaries, & more.
🩺 Visit The Lancet’s Clinical Resources hub: spkl.io/63326A2CLp
New research article
Classification and sequencing of #hepatitis D virus from a large cohort of chronically infected individuals paired with co-infecting hepatitis B virus sequencing: a genomic characterisation study
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #ViroSky #HDV #HBV #OA
April cover of The Lancet Microbe
Our April issue is now online:
www.thelancet.com/journals/lan...
Our journal is #OpenAccess, so you are free to explore all of our content. But these hashtags offer a flavour: #CRISPR #Bordetella #pertussis #microbiome #MicrobiotaTransplant #aspergillosis #BSI #AMR
#IDSky #ClinMicro #OA
What drives better outcomes?
Receiving ≥3 susceptible drugs was key to treatment success & very short regimens (≤9 months) were linked to worse outcomes.
Optimising regimen strength & tracking relapse-free survival should be central to MDR-TB care.
Multidrug-resistant #TB (MDR-TB) outcomes may be better than we think.
In a national cohort from Latvia, only 4.8% met WHO-defined cure—but 76.9% achieved long-term relapse-free survival.
👇
thelancet.com/journals/lan...
📅 Ursula Hofer and Saleha Hassan will be attending ESCMID 2026, #ESCMIDGlobal2026, April 17-21, 2026 in Munich on behalf of The Lancet Infectious Diseases!
📧Feel free to reach out with enquiries. Explore our scope, reach & impact, commitment to publishing excellence, & more: hubs.li/Q03BL6Th0
📢 New Issue Alert. The latest eBioMedicine issue is out now—featuring cutting-edge #TranslationalResearch across #GlobalHealth, #AI, #neuroscience, #oncology & more. 🔬 From maternal–fetal health to AI in clinical research, explore new insights shaping the future of medicine.
Save the Date for the Lyon One Health Summit, 7 April 2026.
🌐 One Health is on the agenda.
Join The Lancet’s Richard Horton live at the One Health Summit High-level Session.
Tomorrow, global leaders meet in Lyon & online to accelerate action—and The Lancet is part of it.
Learn more: spkl.io/63321A2ZrU
Promotional card announcing the launch of The Lancet Regional Health - Eastern Mediterranean. Text on card reads: Discover a new open access journal advancing clinical practice and health policy in the Eastern Mediterranean. Image depicts a woman sitting in a chair while speaking to a doctor holding an electronic tablet.
🆕 Introducing The Lancet Regional Health – Eastern Mediterranean, a new #goldopenaccess journal promoting the advancement of clinical practice and health policy in the Eastern Mediterranean.
Discover the new addition to The Lancet Group at: spkl.io/63328AFIyw #medsky
Research in context panel for paper published in The Lancet Neurology, entitled "Global, regional, and national burden of meningitis, its risk factors, and aetiologies, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023" Copyright: 2026 Elsevier Ltd. All rights reserved.
In 2023, there were over 250,000 deaths from meningitis globally, with over one third in children under five, suggests most comprehensive global assessment to date.
Find out more in @thelancetneuro.bsky.social: spkl.io/63327AF85U @ihmeuw.bsky.social
Figure: Organ dysfunctions in sepsis. Created in BioRender. Singer, M (2025) https://BioRender.com/l1o1l55. ARDS=acute respiratory distress syndrome. Copyright: Elsevier Ltd. All rights are reserved.
Sepsis is a serious condition where the body’s response to an infection becomes out of control and starts to damage its own organs.
A Seminar explores the complexity of the condition, and discusses current challenges and future developments in care: spkl.io/63323AFBJZ
New review article
WHO assessment of the preclinical #antifungal pipeline: evaluating innovation and preparedness in the face of emerging fungal threats
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #MycoSky #OpenAccess #OA
New research article
Vaginal microbiota transplantation for treatment of vaginal dysbiosis without the use of antibiotics: a double-blind, randomised controlled trial in women with vaginal dysbiosis
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #OpenAccess #OA
🆕 The burden of chronic hepatitis B and C in 2022 and progress towards elimination: a global report
www.thelancet.com/journals/lan...
#LiverSky #IDSky #HepSky #MedSky
New comment
Treatment of multidrug-resistant Gram-negative infections: a stewardship imperative
www.thelancet.com/journals/lan...
New Research
Survival trends in patients with difficult-to-treat, antibiotic-resistant, Gram-negative infections in the era of next-generation antibiotics in the USA: a retrospective cohort study
www.thelancet.com/journals/lan...
Read our April issue!
Featuring the global burden of lower respiratory tract infections, comparing test algorithms for syphilis, and chikungunya vaccination in adolescents.
bit.ly/4m1TuYb
📢NEW: March issue now online featuring #obesity, #endometriosis, #KawasakiDisease, #diabetes, #SpinalCordInjury, #HIV, and much more with our editorial on risks of AI-generated health advice
…all available #free, #OpenAccess❗️
Read here: www.thelancet.com/issue/S2589-...
Attribution: Getty
#MedSky
