VapC36-mediated intrinsic stress adaption is required for copper tolerance and pathogenesis of Mycobacterium tuberculosis VapC36 interacts with noncognate VapB antitoxins, degrades serX tRNA, and contributes to copper tolerance in M. tuberculosis.

Ever wondered why Mycobacterium tuberculosis encodes so many toxin–antitoxin systems? Could they be “cross-talking”? In our latest study published in Science advances we demonstrate that high-affinity crosstalk exists among Mtb TA systems and much |Science Advances www.science.org/doi/10.1126/...

Many of you in the mycobacterial community attended the awesome inaugural 2025 Biology of Mycobacteria GRC, organized by @heran.bsky.social and myself: www.grc.org/biology-of-m....

I am writing with an update about this conference as the new chair.

While everyone is hustling for the holidays, hopefully folks will have time to submit abstracts or register for #ASMMicrobe2026 in DC! Please repost!

🚨 𝐍𝐞𝐰 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭 𝐟𝐫𝐨𝐦 𝐨𝐮𝐫 𝐥𝐚𝐛, 𝐚𝐧𝐝 𝐚 𝐟𝐢𝐫𝐬𝐭 𝐢𝐧 𝐭𝐡𝐞 𝐓𝐁 𝐟𝐢𝐞𝐥𝐝! 🚨

We’re thrilled to share our new study revealing how the chromatin regulator SP140 preserves protective T cell immunity during #tuberculosis infection by restraining harmful type I IFN responses.

📖 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝗿𝗲𝗽𝗿𝗶𝗻𝘁: shorturl.at/r5jd9

Happy to share our latest NAR paper on Rel toxins targeting M. tuberculosis anti-SD region, with Tim Blower’s team (@durham.ac.uk @nebiolabs.bsky.social) and Laurent Falquet
Thanks to FRM @frm-officiel.bsky.social and CNRS @cnrsbiologie.bsky.social
academic.oup.com/nar/article-...

Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular

while we wait for #adaptive #tissue #immunity to take off in August ... join us!!! register by end of May
meetings.embo.org/event/25-bar...

@eurovision.tv
#ArtBasel
youtu.be/xyTEK-jUlZo
www.youtube.com/watch?v=bi2Y...

Looks like some CRISPR evolved form TA systems, exciting!

Reprogrammable RNA-targeting CRISPR systems evolved from RNA toxin-antitoxins: Cell www-cell-com.insb.bib.cnrs.fr/cell/fulltex...

LoVis4u: a locus visualization tool for comparative genomics and coverage profiles Abstract. Comparative genomic analysis often involves visualization of alignments of genomic loci. While several software tools are available for this task

Excited to share that our paper on locus visualisation tool LoVis4u is out! Entirely driven by fantastic PhD student Artyom Egorov @egorov.bsky.social academic.oup.com/nargab/artic...

Cheap, smart and efficient: how giant rats are transforming the fight against TB After success in Tanzania, other African countries may introduce the rodents to help sniff out the disease

“… rats have detected #Tuberculosis but follow up clinical tests have been negative; in some of these cases, patients later developed TB... Apopo is monitoring these patients to better understand rats’ sensitivity to low levels of bacteria”.
www.theguardian.com/global-devel...

There are now 24 step-by-step guides, explaining how to create these ⬇️ data visualizations with R/ggplot2 - I hope this is a useful resource. Find them all here: joachimgoedhart.github.io/DataViz-prot...

Also by @wcm-imp.bsky.social alum @norapyenson.bsky.social ! Congrats!

Speaker line up for #EMBOTissueImmunity to take place in Basel 🇨🇭 26-29 August 2025. Come join @maurogaya.bsky.social and I for some fantastic #immunology along the Rhine! Please share this invitation - we hope you will join us. Registrations will be open soon.

Believe it or not, GRC has told me we need more registered applicants or this meeting might not survive! Please don't let that happen if you can afford to attend 🙏

Please add me as well @oneyrolles.bsky.social

Congratulations to the team

An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utilization at acidic pH | mBio Despite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease killer worldwide. A better understanding of the en...

Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt.bsky.social and @healycl.bsky.social without who this would not have been possible 😘
journals.asm.org/doi/10.1128/...

Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis Communications Biology - The ectopic expression of VapC13 and VapC26 results in transcriptional reprogramming of M. tuberculosis. Both, VapBC13 and VapBC26 TA systems are dispensable for infection...

Happy to share that a part of my PhD work published in Communications Biology rdcu.be/dYA61. In this work we have characterised VapBC13 and VapBC26 TA systems. Thanks to Dr Raman and team for support.