Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
New Title Alert: easymode- a collection of general pretrained networks for cellular cryoET.
Learn more here: buff.ly/mLbcUbZ
#SBGrid #SBGridSoftware
Pepper, an 8-month old black cat, gazes longingly into the camera as he begs to be fed on the morning of Friday, March 13, 2026.
It's Friday the 13th, which means it is a black cat appreciation day!
#BlackCat
Just here to pay my regular #CatTax by sharing some photos of Pepper from this past week. #CatsofBlueSky
Pepper, a black kitten, lays on a cat tree.
Pepper, a black kitten, sits contently on the bed next to a stuffed animal as he receives affection.
Happy #Caturday.
Got Pepper's collar back on him last night. Snapped this photo as he played with his toy. Only time will tell if the collar stays on!
#NewCoverImage #CatsofBluesky
I've been working on Surface Morphometrics for a new version (coming soon), and made some significant (AI-assisted) performance improvements, especially in pycurv (20-50x!). If you've had technical issues or just felt like it was too slow, give it another try! #teamtomo github.com/GrotjahnLab/...
Our paper is finally out!
I’m proud to share this collaborative work using FIB milling and cryo-electron tomography to study tick-borne flavivirus replication. Thanks to all co-authors and collaborators — great teamwork #CryoET #ElectronTomography #Virology #Flavivirus #Microscopy #StructuralBiology
Pepper, a six-month-old black domestic short hair, looks out from his carrier at the viewer with his golden yellow eyes.
It’s been an adventure this weekend. On Saturday I adopted this little guy at the Oregon Humane Society and have been working on getting him settled. He is shy, but he has a very loud purr when he gets his neck pets and scratches. He also loves Churus! Say hello to Pepper! #Cats #SpecialRescue
#teamtomo gets another quantitative cell biology tool!
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
By leveraging in situ cryo-ET, Tian et al. obtained high-resolution, #3D views of the native #ultrastructure of intact hippocampal #synapses. See here: doi.org/10.1007/s122...
Happy new year #teamtomo! We've resumed our OHSU tomo journal club, and this year I am going to be sharing it on bluesky. This week we did a roundtable, where attendees each brought a paper and did a 3-5 minute discussion of what they thought was cool about it. Here are the papers they discussed!
Online today, the journal version of our ( @nanigrotjahn.bsky.social @attychang.bsky.social @mmedina300kv.bsky.social) manuscript from earlier this year describing membrane thickness measurement in cells with #teamtomo! rupress.org/jcb/article/...
Oreo, a black and white bicolor cat, in an empty Amazon box on Christmas morning.
May your holidays have the joy of a cat in an empty box on Christmas. #HappyHolidays #Christmas
In the Ring: Details of the bacterial cell division structure the Z-ring revealed using cryo-ET
📷 Adrián Merino-Salomón et al @mpibiochem.bsky.social in
@elife.bsky.social
➡️ bpod.org.uk/archive/2025... with
John Ankers
I am so grateful Apple brought Preview to the iPad on OS 26. It has made being without my MacBook for the week so much easier. The iPad is still not a laptop replacement, but it has gotten much closer to that recently.
Excited to share our preprint on cytoskeletal organization in astrocytes!
biorxiv.org/content/10.110…
Postdoc @mewynne759 looked at microtubules, IFs/GFAP & actin along long elaborate processes.
Wonderful to collaborate w postdoc @dharshinigopal & @NogalesLab on cryo-ET 🤓
1/x
Figure 1 from the preprint
Check out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️
www.biorxiv.org/content/10.1...
#teamtomo
Woo! My lab's Nature Protocols paper is out today.
In a nutshell, the protocol shows how to use our Cryo-ET software to solve high-res protein structures.
I don't think any of the other authors are here, but congrats to Hsuan-Fu, Ye, and Wendy for all of their work!
www.nature.com/articles/s41...
Structural dynamics of mitochondrial ATP synthase in Chlamydomonas reinhardtii revealed by in situ CryoET www.biorxiv.org/content/10.1101/2025.09....
I realize I don't post much, but figured I would share an update. As of today, I am officially supported by the Interdisciplinary Training in Microbial Pathogenesis and Immunology T32 Training grant.
Interior view of a hallway at OHSU with an inspirational quote on the wall reading "Is there a higher calling than curing cancer?" and the OHSU logo displayed.
"We couldn’t be more excited about the transformational potential of this work for humanity."
- Phil and Penny Knight on their historic $2 billion gift to @ohsuknight.bsky.social to transform the future of cancer care and set a new standard globally.
#GiveCancerHell
Took this photo of the Tilikum Bridge on my walk this morning. Beautiful weather this morning. #PDX
Gokul Adethya, Bhanu Pratyush Mantha, Tianyang Wang, Xingjian Li, Min Xu: SaSi: A Self-augmented and Self-interpreted Deep Learning Approach for Few-shot Cryo-ET Particle Detection https://arxiv.org/abs/2505.19948 https://arxiv.org/pdf/2505.19948 https://arxiv.org/html/2505.19948
This is really nice CryoET work and video.
paper link: www.science.org/doi/10.1126/...
‘Forever chemicals’ self-assemble into stable structures resembling biological cells — a behaviour that could help to explain why they stick around for decades in the soil or groundwater
https://go.nature.com/3F02sEd
