Proud to kick-off #HetCCI, a DFG-funded research consortium in Germany (Priority Programme #SPP2493 on heterotypic cell-cell interactions in epithelia). Follow us if interested in how epithelial cells interact with non-epithelial tissues in different settings! Webpage will follow asap. #cellbiology

FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression This study demonstrates that inducible, adipocyte-specific overexpression of FGF21 in adult male mice improves metabolic health and extends lifespan during high-fat diet feeding. These benefits occur independently of growth suppression and are associated with reduced visceral adipose inflammation and ceramide levels, offering mechanistic insights into FGF21’s pro-longevity effects under metabolic stress.

Online now: FGF21 promotes longevity in diet-induced obesity through metabolic benefits independent of growth suppression

Mark Huising is chairing today's debate with Pedro Herrera, Caroline Bonner, Patrik Rorsman, and Sarah Richardson.

🗣️ Are alpha cells and glucagon needed for islet function and glucose homeostasis? This topic is currently being discussed at the EISG conference in Malmö. Mark Huising is chairing the debate with Pedro Herrera, Caroline Bonner, Patrik Rorsman, and Sarah Richardson.
@huisinglab.bsky.social #EISG2025

Fantastic symposium on circuit function last week here at CIPMM. Thanks to our guests Kristina Lippmann, Magdalene Schlesiger, Fiona Muellner and @juliaveit.bsky.social for sharing their latest on synaptic function, interneuron & pyramidal cell networks and long-range communication.

Unravelling cysteine-deficiency-associated rapid weight loss - Nature Conditional cysteine restriction in mice causes substantial weight loss, exceeding that seen with essential amino acid restriction, by activating the integrated stress and oxidative stress respon...

Cysteine restriction, by depleting GSH and CoA, exerts a maximal impact on weight loss, metabolism and stress signalling and is proposed as a strategy to combat a range of metabolic disorders @nature.com www.nature.com/articles/s41...

Are you based in the U.S. 🇺🇸 or Canada 🇨🇦 and thinking of doing research in Europe?

ERC grants offer up to €4.5 million to support groundbreaking, investigator-driven frontier research in all fields.

Watch the dedicated info session for researchers in your region👉 youtu.be/92QYink1Lik

#ChooseEurope

New Faraday Fellowships for international applicants moving to the UK

Up to £4 million per researcher over 5-10 years

Fast-track option for mid-career researchers looking to relocate to the UK

Check out our new preprint "Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis" featuring Ca2+ imaging and timelapse imaging of human T1D insulitis. Very proud of this massive effort by first-author @molliehuber.bsky.social
www.biorxiv.org/content/10.1...

New Professor position at Saarland University for Cell Physiology!

W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) - Universität des Saarlandes Universität des Saarlandes bietet Stelle als W2 Professorship (with tenure track to W3) in the Dynamics of Biological Systems (m/f/x) in Saarbrücken - jetzt bewerben!

We are looking for a new colleague in the biology department at Saarland University!

We are looking for excellent Cell Biologists / Cell Physiologists for a W2 tenure track W3 professorship in 'Dynamics of Biological Systems'.

Please share!

jobs.zeit.de/jobs/w2-prof...

Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling FGF21, a mainly liver-derived hormone, has multiple beneficial metabolic effects. Sobuj Mia et al. reveal a pathologic FGF21-based hepato-cardiac crosstalk mechanism that is induced with pressure over...

www.cell.com/cell-reports...

Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - Diabetologia Aims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A...

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

Animal experiments in Germany are becoming increasingly bureaucratic, expensive, and difficult to conduct. There is currently a campaign supporting ethical and regulated animal experimentation, while also advocating for the preservation of research freedom.

Right? So surprising 😒😒

Monitoring subcellular NADP redox state with NAPstar biosensors

Monitoring subcellular NADP redox state with NAPstar biosensors @riemerlab.bsky.social @morganlab-saarland.bsky.social
@jan-oleniemeier.bsky.social

www.sciencedirect.com/science/arti...

Canadian scientist Daniel Drucker among winners of Breakthrough Prize for discovery of hormone used in anti-obesity drugs Senior investigator at Mount Sinai Hospital was one of five researchers jointly awarded US$3-million in world’s largest science prize

Canadian scientist Daniel Drucker among winners of prestigious Breakthrough Prize for discovery of hormone used in anti-obesity drugs, by @ivansemeniuk.bsky.social www.theglobeandmail.com/canada/artic... via @theglobeandmail.com #WeightLoss #diabetes

Breakthrough Prize – Breakthrough Prize Announces 2025 Laureates in Life Sciences, Fundamental Physics, and Mathematics

Congrats @danieljdrucker.bsky.social!! breakthroughprize.org/News/91

Max Planck Research Group Leader (W2) in Molecular Design We are looking for exceptional early-career scientists conducting computational research with a proven record of accomplishment. The primary focus of this call is on candidates proposing research on b...

Job alert: Join us in Mainz as

Max Planck Research Group Leader (W2) in Molecular Design

...and make your own research dreams happen on de novo design, generative models, proteins, materials ...
tinyurl.com/r2xjxnuk

@mpip-mainz.mpg.de

Here we report that individual leader and hub beta cells are stable in vivo, regulated by glycemic status and acutely by GLP-1RA. #LuisDelgadillo www.biorxiv.org/content/10.1...

Metabolic and paracrine heterogeneity of pancreatic glucagon-secreting α-cells By stimulating hepatic glucose production, glucagon (released by islet α-cells) restores normal blood glucose levels when they fall below the normal range.

Electrophysiological characterization reveals more complexity for islet α-cell heterogeneity #islets diabetesjournals.org/diabetes/art...

TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion - Diabetologia Aims/hypothesis Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunct...

RNA-seq analysis and experimental exploration show that TMEM55A-mediated PI5P signalling regulates #alphacell actin depolymerisation and #glucagon secretion. #islets, #diabetes link.springer.com/article/10.1... 🔓 @xiongliu.bsky.social @bcellorg.bsky.social

First map of human brain mitochondria is ‘groundbreaking’ achievement Nature - Hundreds of cubes of human brain tissue help scientists to chart the energy-making capabilities of various brain regions.

🧪 Scientists have created the first map of mitochondria throughout the entire brain

https://go.nature.com/42j9YCV

Dear US researchers: Welcome to Germany! – DW – 03/27/2025 Trump's massive attack on science is driving US researchers away. German research institutions could benefit, but they’re also concerned about Trump’s impact on global science.

p.dw.com/p/4sLeW

My first PhD student just defended his thesis! Congratulations Dr. Carlein 😍

Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model - Nature Metabolism Rabah et al. discover an astrocyte-to-neuron hydrogen peroxide signalling cascade, which is crucial for long-term memory formation in Drosophila. This signalling is found to be inhibited by amyloid-β ...

www.nature.com/articles/s42...

The clinical antiprotozoal drug halofuginone promotes weight loss by elevating GDF15 and FGF21 Halofuginone curbs weight gain in mice and pigs.

Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models www.science.org/doi/10.1126/...

thenode.biologists.com/jobs/opening...

Really nice Amelia !

Cardioprotective effects of semaglutide on isolated human ventricular myocardium Semaglutide reduces late sodium current (INa) and diastolic calcium (Ca) sparks in human cardiomyocytes from aortic stenosis (AS) and end-stage heart failure with reduced ejection fraction (HFrEF) pa...

Analysis of the direct cardioprotective effects of semaglutide on human and mouse cardiomyocytes ex vivo with a focus on ion currents, signal transduction, and contractility onlinelibrary.wiley.com/doi/10.1002/...

They’re not thoughts you've previously had … They’re in complete contrast with your entire belief system. —Susanne Schweizer, UNSW Sydney

One of my first memories of my daughter is a mental image of her being grievously harmed. No one told me such intrusive thoughts are nearly universal after giving birth. That and more of the best from @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪